Yuto Uchida, MD, PhD

Assistant Professor of Radiology and Radiological Science

Dr. Uchida’s research focus centers on ex vivo studies comparing histological observation and MRI. He examined neurodegenerative changes in the entorhinal-hippocampal pathway using ultra-high-field diffusion tensor imaging and tractography in postmortem brain tissues. The study identified significant alterations in the entorhinal layer II and perforant pathway fibers along the Alzheimer's disease continuum, providing valuable insights into early neurodegenerative processes (Alzheimers Dement. 2025;21:e70142). He has also played a key role in analyzing the BIOCARD cohort, a landmark Johns Hopkins–led longitudinal study spanning 30 years for the Alzheimer's disease continuum. He synthesized extensive structural MRI data to demonstrate that alterations in white matter and ventricular structures are strongly influenced by diabetes and amyloid-β pathology (JAMA Netw Open. 2024;10:e2441505). Furthermore, his analyses revealed that structural change-points in these regions precede hippocampal alterations (Alzheimers Dement. 2025;21:e70544), advancing our understanding of the temporal sequence of neurodegenerative processes.

https://scholar.google.com/citations?user=rKPaAF4AAAAJ&hl=ja

https://www.ncbi.nlm.nih.gov/myncbi/yuto.uchida.1/bibliography/public/

• Uchida Y, Hou Z, Gomez-Isaza L, Luongo M, Troncoso JC, Miller MI, Mori S, Oishi K. Quantification of perforant path fibers for early detection of Alzheimer's disease. Alzheimers Dement. 2025;21:e70142.

• Uchida Y, Nishimaki K, Soldan A, Pettigrew C, Ho SG, Moghekar A, Wang MC, Miller MI, Marilyn Albert M, Oishi K. Change points for dynamic biomarkers in the Alzheimer’s pathological cascade: a 30-year cohort study. Alzheimers Dement. 2025;21:e70544. 

• Uchida Y, Onda K, Nishimaki K, Kucharska-Newton AM, Windham BG, Wasserman BA, Oishi K. Longitudinal changes in brain diffusion characteristics associated with cognition and vascular risks: the atherosclerosis risk in communities neurocognitive study. Neurology. 2025;105:e213867.

• Uchida Y, Kano Y, Kan H, Sakurai K, Morita H, Akagawa Y, Matsukawa N, Oishi K. Blood-brain barrier water exchange and paramagnetic susceptibility alterations during anti-amyloid therapy: preliminary MRI findings. J Prev Alzheimers Dis. 2025;12:100256.

• Uchida Y, Nishimaki K, Soldan A, Moghekar A, Albert M, Oishi K. Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment. JAMA Netw Open. 2024;10:e2441505.

• Overseas Research Fellowship, 2022 – 2025, Takeda Science Foundation, 4,800,000 Japanese Yen per year, Magnetic Resonance Research
• New Investigator Awards, 2024 – 2026, Alzheimer’s Association and National Alzheimer’s Coordinating Center, $148,412, Principal Investigator, In vivo quantification of entorhinal cortex layer II along the AD continuum 
• K99/R00 Award, 2024 – 2029, National Institute of Aging, $941,793, Principal Investigator, Quantification of microstructures in the entorhinal-hippocampus pathway as a sensitive biomarker for neurodegeneration during the preclinical stage of Alzheimer's disease
• Junior Faculty Award, The 20th International Conference on Alzheimer's & Parkinson's Diseases and related neurological disorders (AD/PD 2026), Principal Investigator, QUANTIFICATION OF PERFORANT PATH FIBERS FOR EARLY DETECTION OF ALZHEIMER’S DISEASE

• Resident in Internal Medicine, Nagoya City University Hospital, 2009 – 2011
• Clinical Fellow in Neurology, Tosei General Hospital, Aichi, Japan, 2011 – 2014
• Clinical Fellow in Neurology, Toyokawa City Hospital, Aichi, Japan, 2014 – 2016