Wayne Koch, MD

Primary Academic Title

Professor of Otolaryngology-Head and Neck Surgery

Background

Centers and Institutes

• Head and Neck Tumor Center
• Sidney Kimmel Comprehensive Cancer Center

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Videos

• Meet our Experts - Dr. Wayne Koch

Additional Academic Titles

Professor of Oncology

Research Interests

Genetic changes associated with head and neck cancer, Human Papillomavirus (HPV) as causal factor of head and neck cancer, Use of genetic changes as markers for early detection, prognostic factors to select treatment, targets for therapy

PubMed - Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=Koch%20W%5BAuthor%5D&cauthor=true&cauthor_uid=16415423

Selected Publications

• Ha, P.K.; Hdeib, A.; Goldenberg, D.; Jacene, H.; Patel, P.; Koch, W.; Califano, J.; Cummings, C.W.; Flint, P.W.; Wahl, R.; Tufano, R.P. The role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Jan;132(1):12-16.
  
  Jiang, W.W.; Rosenbaum, E.; Mambo, E.; Zahurak, M.; Masayesva, B.; Carvalho, A.L.; Zhou, S.; Westra, W.H.; Alberg, A.J.; Sidransky, D.; Koch, W.; Califano, J.A. Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients. Clin Cancer Res. 2006 Mar 1;12(5):1564-1569.
  
  Jiang, W.W.; Zahurak, M.; Goldenberg, D.; Milman, Y.; Park, H.L.; Westra, W.H.; Koch, W.; Sidransky, D.; Califano, J. Increased plasma DNA integrity index in head and neck cancer patients. Int J Cancer. 2006 Dec 1;119(11):2673-2676.
  
  Masayesva, B.G.; Mambo, E.; Taylor, R.J.; Goloubeva, O.G.; Zhou, S.; Cohen, Y.; Minhas, K.; Koch, W.; Sciubba, J.; Alberg, A.J.; Sidransky, D.; Califano, J. Mitochondrial DNA content increase in response to cigarette smoking. Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):19-24.
  
  Serafini, P.; Meckel, K.; Kelso, M.; Noonan, K.; Califano, J.; Koch, W.; Dolcetti, L.; Bronte, V.; Borrello, I. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med. 2006 Nov 27;203(12):2691-2702.
  
  Wolpoe, M.E.; Goldenberg, D.; Koch, W.M. Squamous cell carcinoma of the sinonasal cavity arising as a second primary in individuals with head and neck cancer. Laryngoscope. 2006 May;116(5):696-699.
  
  Couch, M.E.; Ferris, R.L.; Brennan, J.A.; Koch, W.M.; Jaffee, E.M.; Leibowitz, M.S.; Nepom, G.T.; Erlich, H.A.; Sidransky, D. Alteration of cellular and humoral immunity by mutant p53 protein and processed mutant peptide in head and neck cancer. Clin Cancer Res. 2007 Dec 1;13(23):7199-7206.
  
  D'Souza, G.; Kreimer, A.R.; Viscidi, R.; Pawlita, M.; Fakhry, C.; Koch, W.M.; Westra, W.H.; Gillison, M.L. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med. 2007 May 10;356(19):1944-1956.
  
  Farrag, T.Y.; Boahene, K.D.; Agrawal, N.; Turner, L.; Byrne, P.J.; Earnest, L.; Koch, W.M.; Tufano, R.P. Use of fibrin sealant in closing mucocutaneous fistulas following head and neck cancer surgery. Otolaryngol Head Neck Surg. 2007 Jul;137(1):159-161.
  
  Farrag, T.Y.; Koch, W.M.; Cummings, C.W.; Goldenberg, D.; Abou-Jaoude, P.M.; Califano, J.A.; Flint, P.W.; Webster, K.; Tufano, R.P. Supracricoid laryngectomy outcomes: The Johns Hopkins experience. Laryngoscope. 2007 Jan;117(1):129-132.
  
  Farrag, T.Y.; Lin, F.R.; Koch, W.M.; Califano, J.A.; Cummings, C.W.; Farinola, M.A.; Tufano, R.P. The role of pre-operative CT-guided FNAB for parapharyngeal space tumors. Otolaryngol Head Neck Surg. 2007 Mar;136(3):411-414.
  
  Lin, C.J.; Grandis, J.R.; Carey, T.E.; Gollin, S.M.; Whiteside, T.L.; Koch, W.M.; Ferris, R.L.; Lai, S.Y. Head and neck squamous cell carcinoma cell lines: established models and rationale for selection. Head Neck. 2007 Feb;29(2):163-188.
  
  Mithani, S.K.; Smith, I.M.; Zhou, S.; Gray, A.; Koch, W.M.; Maitra, A.; Califano, J.A. Mitochondrial resequencing arrays detect tumor-specific mutations in salivary rinses of patients with head and neck cancer. Clin Cancer Res. 2007 Dec 15;13(24):7335-7340.
  
  Mithani, S.K.; Taube, J.M.; Zhou, S.; Smith, I.M.; Koch, W.M.; Westra, W.H.; Califano, J.A. Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4331-4335.
  
  Nayak, C.S.; Carvalho, A.L.; Jeronimo, C.; Henrique, R.; Kim, M.M.; Hoque, M.O.; Chang, S.; Jiang, W.W.; Koch, W.; Westra, W.; Sidransky, D.; Califano, J. Positive correlation of tissue inhibitor of metalloproteinase-3 and death-associated protein kinase hypermethylation in head and neck squamous cell carcinoma. Laryngoscope. 2007 Aug;117(8):1376-1380.
  
  Poeta, M.L.; Manola, J.; Goldwasser, M.A.; Forastiere, A.; Benoit, N.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med. 2007 Dec 20;357(25):2552-2561.
  
  Zhou, S.; Kachhap, S.; Sun, W.; Wu, G.; Chuang, A.; Poeta, L.; Grumbine, L.; Mithani, S.K.; Chatterjee, A.; Koch, W.; Westra, W.H.; Maitra, A.; Glazer, C.; Carducci, M.; Sidransky, D.; McFate, T.; Verma, A.; Califano, J.A. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7540-7545.
  
  Agrawal, Y.; Koch, W.M.; Xiao, W.; Westra, W.H.; Trivett, A.L.; Symer, D.E.; Gillison, M.L. Oral human papillomavirus infection before and after treatment for human papillomavirus 16-positive and human papillomavirus 16-negative head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Nov 1;14(21):7143-7150.
  
  Carvalho, A.L.; Jeronimo, C.; Kim, M.M.; Henrique, R.; Zhang, Z.; Hoque, M.O.; Chang, S.; Brait, M.; Nayak, C.S.; Jiang, W.W.; Claybourne, Q.; Tokumaru, Y.; Lee, J.; Goldenberg, D.; Garrett-Mayer, E.; Goodman, S.; Moon, C.S.; Koch, W.; Westra, W.H.; Sidransky, D.; Califano, J.A. Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Jan 1;14(1):97-107.
  
  Chuang, A.Y.; Chuang, T.C.; Chang, S.; Zhou, S.; Begum, S.; Westra, W.H.; Ha, P.K.; Koch, W.M.; Califano, J.A. Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma. Oral Oncol. 2008 Oct;44(10):915-919.
  
  Goldenberg, D.; Begum, S.; Westra, W.H.; Khan, Z.; Sciubba, J.; Pai, S.I.; Califano, J.A.; Tufano, R.P.; Koch, W.M. Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck. 2008 Jul;30(7):898-903.
  
  Rudin, C.M.; Liu, W.; Desai, A.; Karrison, T.; Jiang, X.; Janisch, L.; Das, S.; Ramirez, J.; Poonkuzhali, B.; Schuetz, E.; Fackenthal, D.L.; Chen, P.; Armstrong, D.K.; Brahmer, J.R.; Fleming, G.F.; Vokes, E.E.; Carducci, M.A.; Ratain, M.J. Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity. J Clin Oncol. 2008 Mar 1;26(7):1119-1127.
  
  Westra, W.H.; Taube, J.M.; Poeta, M.L.; Begum, S.; Sidransky, D.; Koch, W.M. Inverse Relationship between Human Papillomavirus-16 Infection and Disruptive p53 Gene Mutations in Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res. 2008 Jan 15;14(2):366-369.
  
  Koch, W.M.; Ridge, J.A.; Forastiere, A.; Manola, J. Comparison of clinical and pathological staging in head and neck squamous cell carcinoma: results from Intergroup Study ECOG 4393/RTOG 9614. Arch Otolaryngol Head Neck Surg. 2009 Sep;135(9):851-858.
  
  Poeta, M.L.; Manola, J.; Goldenberg, D.; Forastiere, A.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. The Ligamp TP53 Assay for Detection of Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma Surgical Margins. Clin Cancer Res. 2009 Dec 15;15(24):7658-7665.
  
  Rudin, C.M.; Avila-Tang, E.; Harris, C.C.; Herman, J.G.; Hirsch, F.R.; Pao, W.; Schwartz, A.G.; Vahakangas, K.H.; Samet, J.M. Lung cancer in never smokers: molecular profiles and therapeutic implications. Clin Cancer Res. 2009 Sep 15;15(18):5646-5661.
  
  Sanguineti, G.; Califano, J.; Stafford, E.; Fox, J.; Koch, W.; Tufano, R.; Sormani, M.P.; Forastiere, A. Defining the Risk of Involvement for Each Neck Nodal Level in Patients With Early T-Stage Node-Positive Oropharyngeal Carcinoma. Int J Radiat Oncol Biol Phys. 2009 Jan 6
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  Shi, C.; Chandrasekaran, A.; Thuluvath, P.J.; Karikari, C.; Argani, P.; Goggins, M.; Maitra, A.; Eshleman, J.R. Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology. J Mol Diagn. 2009 Nov;11(6):583-589.
  
  Talay, O.; Shen, C.H.; Chen, L.; Chen, J. B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2741-2746.
  
  Dasgupta, S.; Koch, R.; Westra, W.H.; Califano, J.A.; Ha, P.K.; Sidransky, D.; Koch, W.M. Mitochondrial DNA mutation in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients. Cancer Prev Res (Phila). 2010 Sep;3(9):1205-1211.
  
  Demokan, S.; Chang, X.; Chuang, A.; Mydlarz, W.K.; Kaur, J.; Huang, P.; Khan, Z.; Khan, T.; Ostrow, K.L.; Brait, M.; Hoque, M.O.; Liegeois, N.J.; Sidransky, D.; Koch, W.; Califano, J.A. KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses. Int J Cancer. 2010 Nov 15;127(10):2351-2359.
  
  Gourin, C.G.; Tufano, R.P.; Forastiere, A.A.; Koch, W.M.; Pawlik, T.M.; Bristow, R.E. Volume-based trends in thyroid surgery. Arch Otolaryngol Head Neck Surg. 2010 Dec;136(12):1191-1198.
  
  Kandil, E.H., Zeiger, M.A., Tufano, R.P. Solitary Thyroid Nodule In: Koch, W.M., editor, Early Diagnosis and Treatment of Cancer Head and Neck Cancer. Philadelphia: Elsevier; 2010.
  
  Loyo, M.; Guerrero-Preston, R.; Brait, M.; Hoque, M.O.; Chuang, A.; Kim, M.S.; Sharma, R.; Liegeois, N.J.; Koch, W.M.; Califano, J.A.; Westra, W.H.; Sidransky, D. Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission. Int J Cancer. 2010 Jun 15;126(12):2991-2996.
  
  Peacock, C.D.; Rudin, C.M. Skin deep and deeper: multiple pathways in basal cell carcinogenesis. Cancer Prev Res (Phila). 2010 Oct;3(10):1213-1216.
  
  Roh, J.L.; Kang, S.K.; Minn, I.; Califano, J.A.; Sidransky, D.; Koch, W.M. p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. Oral Oncol. 2010 Dec 15.
  
  DSouza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356; 19: 1944-1956.
  
  Nayak CS, Carvalho AL, Jeronimo C, Henrique R, Kim MM, Hoque MO, Chang S, Jiang WW, Koch W, Westra W, Sidransky D, Califano J. Positive Correlation of Tissue Inhibitor of Metalloproteinase-3 and Death-Associated Protein Kinase Hypermethylation in Head and Neck Squamous Cell Carcinoma. Laryngoscope 2007 Aug; 117 (8):1376-80.
  
  Goldenberg D, Sciubba J, Koch, WM. Cystic metastasis from head and neck squamous cell cancer: a distinct disease variant? Head Neck 2006 Jul; 28(7): 633-8.
  
  Wolpoe ME, Goldenberg D, Koch WM. Squamous cell carcinoma of the Sinonasal Cavity arising as a Second primary in Individuals with Head and Neck Cancer. Laryngoscope 2006 May; 116(5): 696-699.
  
  Harden SV, Thomas DC, Benoit N, Minhas K, Westra WH, Califano JA, Koch W, Sidransky D. Real-time gap ligase chain reaction: a rapid semiquantitative assay for detecting p53 mutation at low levels in surgical margins and lymph nodes from resected lung and head and neck tumors. Clin Cancer Res. 2004 Apr 1; 10(7):2379 85.
  
  Gourin CG, Forastiere AA, Sanguineti, Koch WM, Marur S. Bristow RE: Impact of surgeon and hospital volume on short-term outcome and cost of laryngeal cancer surgical care. Laryngoscope 2011 Jan; 121(1): 85-90
  
  Gourin CG, Forastiere AA, Sanguineti G, Marur S, Koch WM, Bristow RE. Volume-based trends in laryngeal cancer surgery. Laryngoscope. 2011 Jan; 121(1): 77-84.
  
  Roh J-L, Kang SK, Califano JA, Sidransky D, Koch, WM. p53-Reactivating Small Molecules Induce Apoptosis and Enhance Chemotherapeutic Cytotoxicity in Head and Neck Squamous Cell Carcinoma. Oral Oncol 2011 Jan; 47(1): 8-15.
  
  Starmer H, Agrawal N, Koch W, Richmon, J, Webster K, Gourin CG. Does prosthesis diameter matter? The relationship between voice prosthesis diameter and complications. Otolaryngol Head Neck Surg 2011 May; 144(5): 740-746.
  
  Guerro-Preston R. Soudry E, Acero J, Orera M, Moreno-Lopez L, Macia Colon G, Jaffe A, Berdasco M, Ili-Gangas C, Brebi-Mieville P, Fu Y, Engstrom C, Irizarry R, Esteller M, Westra W, Koch W, Califano J, Sidransky D. NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva. Ca Prev Res, Jul;4(7):1061-72. Epub 2011 May 10.
  
  Gallia GL, Reh DD, Salmasi V, Koch W Isshi M Endonasal Endoscopic Resection of Esthesioneuroblastoma: The Johns Hopkins Hospital Experience and Review of the Literature. Neurosurg Rev 2011, Oct; 34 (4): 465-475, Epub 2011 Jun 8. PMID 21655908
  
  Gourin CG, Forastiere AA, Sanguineti G, Marur S, Koch WM, Bristow RE. Volume-based trends in surgical care of patients with oropharyngeal cancer. Laryngoscope. 2011 Apr; 121(4): 738-745.
  
  Gourin CG, Forastiere AA, Sanguineti G, Marur S, Koch WM, Bristow RE. Impact of surgeon and hospital volume on short-term outcomes and cost of oropharyngeal cancer surgical care. Laryngoscope. 2011 Apr; 121(4) 746-752.
  
  Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie T-X, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Trevio L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN. Exome Sequencing of Head and Neck Squamous Cell Carcinomas Reveals Inactivating Mutations in NOTCH1. Science, 2011, Aug 26;333(6046):1154-7.
  
  Carvalho AL, Henrique R, Jeronimo C, Nayak CS, Reddy AN, Hoque MO, Chang S, Brait M, Jiang WW, Kim MM, Claybourne Q, Goldenberg D, Khan Z, Khan T, Westra WH, Sidransky D, Koch W, Califano JA. Detection of promoter hypermethylation in saliva as a biomarker for head and neck squamous cell carcinoma surveillance. Clin Cancer Res. 2011 Jul 15;17(14):4782-9. May 31 [Epub ahead of print]
  
  Wu G, Chang X, Yun X, Huang W, Koch WM. Prospective randomized trial of high versus low continuous negative pressure suction in management of chyle fistula after neck dissection for metastatic thyroid carcinoma. Accepted for Head Neck Sept, 2011 HED-11-0394.
  
  Roh JL, Westra W, Califano J, Sidransky D, Koch W. Tissue Imprint for Molecular Mapping of Deep Surgical Margins in Patients with Head and Neck Squamous Cell Carcinoma Accepted Sept 2011 Head Neck Jan 3. Doi 1002/hed21982 PMID 222223471
  
  Sun W, Zaboli D, Wang H, Liu Y, Arnaoutakis D, Khan T, Khan Z, Koch WM, Califano JA. Detection of TIMP3 promoter hypermethylation in salivary rinse as an independent predictor of local recurrence-free survival in head and neck cancer. Clin Cancer Res. 2012 Feb 15;18(4):1082-91. Epub 2012 Jan 6.
  
  Loyo M, Schussel J, Colantuoni E, Califano J, Brait M, Kang S, Koch WM, Sidransky D, Westra WH, Taube JM. Detection of Merkel Cell Virus and correlation with histologic presence of Merkel Cell Carcinoma in sentinel lymph nodes. Br J Cancer. 2012 Mar 27;106(7):1314-9.
  
  Chang S, Goldenberg D, Koch WM. The transcervical approach to benign parapharyngeal space tumors. Accepted to Annals Oto Rhino Laryngol MS 11-5152, March, 2012
  
  Roh JL, Ko JH, Moon SJ, Ryu CH, Choi JY, Koch WM.The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer.Cancer Lett. 2012 May 22. [Epub ahead of print] PMID: 22634494
  
  Ogawa T, Liggett TE, Melnikov AA, Monitto CL, Kusuke D, Shiga K, Kobayashi T, Horii A, Chatterjee A, Levenson VV, Koch WM, Sidransky D, Chang X.
  Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance. Cell Cycle. 2012 Apr 15;11(8):1656-63. Epub 2012 Apr 15.
  PMID: 22487682
  
  Sun W, Zaboli D, Liu Y, Arnaoutakis D, Khan T, Wang H, Koch W, Khan Z, Califano Comparison of promoter hypermethylation pattern in salivary rinses collected with and without an exfoliating brush from patients with HNSCC. JA.PLoS One. 2012;7(3):e33642. Epub 2012 Mar 16.PMID: 22438973

Honors

2016 Distinguished Award for Humanitarian Service, Academy of Otolaryngology