Theodore DeWeese, MD

Professional Titles

• The Frances Watt Baker, M.D., and Lenox D. Baker Jr., M.D. Dean of the Medical Faculty and CEO, Johns Hopkins Medicine
• Vice President for Interdisciplinary Patient Care, Johns Hopkins Medicine

Primary Academic Title

Professor of Radiation Oncology and Molecular Radiation Sciences

Background

Centers and Institutes

• Armstrong Institute for Patient Safety and Quality
• Johns Hopkins Greenberg Bladder Cancer Institute
• Sidney Kimmel Comprehensive Cancer Center

Clinical Trial Keywords

Prostate cancer; Gene therapy

Clinical Trials Summary

Learn more about clinical trials at the Johns Hopkins Kimmel Cancer Center.

Find a Clinical Trial

Videos

• Meet Our Expert: Dr. Theodore DeWeese

Recent News Articles and Media Coverage

• Cancer Matters Blog: Johns Hopkins - Everest?
• Advances in Prostate Cancer Radiation Therapy

Additional Academic Titles

Professor of Oncology, Professor of Urology

Research Interests

DNA damage, Prostate Cancer, Radiation sensitization

Research Summary

Dr. DeWeese's research focus is on identifying DNA repair enzymes that, if inactivated, would result in substantial radiation sensitization.  His team has synthesized a chimeric molecule in which a siRNA-targeting DNA repair protein is combined with an aptamer targeting the prostate-unique protein, prostate specific membrane antigen (PSMA). This results in a chimeric siRNA-apatmer that is a potent, targeted radiosensitizer with potential for translation into prostate cancer therapy.  

PubMed - Publications

http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=DeWeese%20tl

Selected Publications

• Alcorn S, Walker AJ, Gandhi N, Narang A, Wild AT, Hales RK, Herman JM, Song DY, DeWeese TL, Antonarakis ES, Tran PT. “Molecularly targeted agents as radiosensitizers in cancer therapy--focus on prostate cancer.” Int J Mol Sci. 2013 Jul 16;14(7):14800-32.

• Kusano AS, Thomas CR Jr, Bonner JA, DeWeese TL, Formenti SC, Hahn SM, Lawrence TS, Mittal BB. “Burnout in United States academic chairs of radiation oncology programs.” Int J Radiat Oncol Biol Phys. 2014 Feb 1;88(2):363-8. doi: 10.1016/j.ijrobp.2013.09.027. Epub 2013 Nov 1.

• Narang AK, Lam E, Makary MA, DeWeese TL, Pawlik TM, Pronovost PJ, Herman JM. “Accuracy of marketing claims by providers of stereotactic radiation therapy.”J Oncol Pract. 2013 Jan;9(1):57-62.

• Song H, Hedayati M, Hobbs RF, Shao C, Bruchertseifer F, Morgenstern A, DeWeese TL, Sgouros G. “Targeting aberrant DNA double-strand break repair in triple-negative breast cancer with alpha-particle emitter radiolabeled anti-EGFR antibody.” Mol Cancer Ther. 2013 Oct;12(10):2043-54. doi: 10.1158/1535-7163.MCT-13-0108. Epub 2013 Jul 19.

• Wada S, Harris TJ, Tryggestad E, Yoshimura K, Zeng J, Yen HR, Getnet D, Grosso JF, Bruno TC, De Marzo AM, Netto GJ, Pardoll DM, DeWeese TL, Wong J, Drake CG. “Combined treatment effects of radiation and immunotherapy: studies in an autochthonous prostate cancer model.” Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):769-76.

Honors

• Director's Teaching Award in Clinical Science, The Johns Hopkins Oncology Center, 1/1/03
• Director's Teaching Award in Basic Science, The Johns Hopkins Oncology Center, 1/1/02
• Doris Duke Research Scientist Award, 1/1/99
• Travel Award, European Society for Therapeutic Radiology and Oncology, 1/1/98
• Travel Grant, American Society for Therapeutic Radiology and Oncology Basic Science, 1/1/95
• Fellowship Award, American Society for Therapeutic Radiology and Oncology Research, 1/1/94
• Chief Resident, Radiation Oncology, The Johns Hopkins Hospital, 1/1/93
• Dean's Letter of Academic Achievement, 1/1/90

Memberships

• American Association for Cancer Research
• American College of Radiology
• American Society for Therapeutic Radiology and Oncology
• American Association for Radiation Oncology,

  President

Professional Activities

• American Association for Cancer Research, Education Committee, 1/1/04
• American Society for Radiation Oncology, President
• American Society for Radiation Oncology, Chair of the Board