Tamara Lotan, MD
Clinical and Laboratory Pathology
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Tamara Lotan
Professional Titles
- Director of Research, The Brady Urological Institute
- Rose-Lee and Keith Reinhard Professor in Urologic Pathology
Primary Academic Title
Professor of Pathology
Johns Hopkins Physician
Background
Dr. Tamara Lotan is a Professor of Pathology, Urology and Oncology at the Johns Hopkins University School of Medicine. Her area of clinical expertise is urologic pathology.
Dr. Lotan received her medical degree from the University of Chicago Pritzker School of Medicine. She completed her residency in anatomic pathology at the University of Chicago Hospitals and performed a fellowship in urologic pathology at the Johns Hopkins University School of Medicine.
She is a urologic pathologist and physician-scientist whose laboratory studies tissue-based predictive and prognostic biomarkers in prostate cancer. The group has a particular interest in the molecular contributors to prostate cancer health disparities. Her group also studies mTOR signaling and its role in tumorigenesis, with a focus on renal oncogenesis.
Dr. Lotan is engaged in research training and is the co-PI of the OPTIC T32 in pathology, enabling pathology residents to engage in 2-3 years of laboratory research. She is currently the Deputy Director for Research Affairs in the Department of Pathology.
Centers and Institutes
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Additional Academic Titles
Joint Appointment in Urology, Professor of Oncology
Research Interests
Prostate cancer, kidney cancer
Research Summary
Dr. Tamara Lotan is a urologic pathologist who studies tissue-based prognostic and predictive biomarkers in prostate cancer. Her lab also studies how oncogenic signaling pathways regulate epithelial morphogenesis, differentiation and growth during embryonic development and tumorigenesis.
Google Scholar - Publications
PubMed - Publications
Selected Publications
- Asrani K, Amaral A, Woo J, Nourmohammadi Abadchi S, Vidotto T, Imada E, Skaist A, Feng K, Liu HB, Kasbe M, Satou Y, Baba M, Oike Y, Outeda P, Watnick T, Rosenberg AZ, Schmidt LS, Linehan WM, Argani P, Lotan TL. SFPQ-TFE3 reciprocally regulates mTORC1 and induces lineage plasticity in a mouse model of renal tumorigenesis. Nat Commun. 2025; 16(1):8822. PMID: 41044182.
- Li H, Amaral A, Vidotto T, Woo J, Liu HB, Oliveira LD, Dairo O, Feng K, Shenderov E, Argani P, Schmidt LS, Linehan WM, Lotan TL*, Asrani K*. mTOR-mediated up-regulation of B7-H3 in MiT/TFE translocation renal cell carcinoma. J Pathol. 2026; 268(1):77-88. PMID: 41178060. *Equal contribution.
- Cha E, Lin Z, Lu J, Oliveira LD, Erak E, Mendes AA, Dairo O, Ertunc O, Kulac I, Baena-Del Valle JA, Jones T, Hicks JL, Glavaris S, Guner G, Vidal ID, Trock BJ, Chattopadhyay N, Joshi U, Kondragunta C, Bonthu S, Han M, Mucci LA, Joshu C, De Marzo AM, Stopsack KH, Singhal N, Lotan TL. Histopathology-based Artificial Intelligence Algorithms for the Prediction of Prostate Cancer Metastasis After Radical Prostatectomy. Eur Urol. 2026, 89(2):140-148. PMID: 41136278
- Amaral A, Vidotto T, Woo J, Rubenstein M, Lu J, Gomes-Alexandre C, De Marzo AM, Sfanos K, Maynard J, Baraban E, Sena LA, Markowski MC, Antonarakis ES, Joshu C, Asrani K, Lotan TL. HLA Class I Expression is Associated with Increased Immune Cell Density and PTEN Loss in Prostate Cancer. Mol Cancer Res, 2026, in press. PMID: 42065732.
- Bhardwaj S, Amaral A, Dairo O, Akbari A, Pivovarcikova K, Williamson SR, Antic T, Argani P, Asrani K, Lotan TL. Association of genomic driver mutation, histologic subtype, and mTORC1 biomarker expression in mTOR pathway-altered renal tumors. Hum Pathol. 2026, in press. PMID: 42155824.
Honors
- 2022-Elected to Interurban Clinical Club
Memberships
- College of American Pathology
- International Society of Urologic Pathology
- United States and Canadian Academy of Pathology
Locations
- The Johns Hopkins Hospital
- 1800 Orleans Street, Baltimore, MD 21287
- Get Directions
- phone: 410-955-5000
- fax: 410-955-5001
Expertise
Education
- Fellowship: Johns Hopkins University School of Medicine, Pathology, 2008
- Residency: University of Chicago Medicine, Anatomic Pathology, 2007
- Residency: University of Chicago Medicine, Anatomic Pathology, 2005
- Medical Education: University of Chicago School of Medicine, MD, 2003
Board Certifications
- Anatomic Pathology: American Board of Pathology, 2007
Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- Veteran Affairs Community Care Network (Optum-VACCN)