T. Jake Samuel, PhD

Primary Academic Title

Assistant Professor of Radiology and Radiological Science

Recent News Articles and Media Coverage

• MRI Could Detect Abnormal Heart Metabolism, Predict Cardiac Death, Oncology Times (August 20, 2022)

Research Interests

Heart Failure, Exercise Intolerance, Aging, Magnetic Resonance Spectroscopy, Magnetic Resonance Imaging, Myocardial Metabolism, Skeletal Muscle Metabolism, Skeletal Muscle Blood Flow, Coronary Microvascular Dysfunction, Wearable Health Technology, People Living with HIV

Research Summary

Dr. Samuel’s research centers on enhancing the understanding and treatment of cardiometabolic disease in patients primarily through advanced magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques. He aims to investigate the intricate relationships between cardiac and skeletal muscle structure, function, and energetics. A particular focus of Dr. Samuel's work is to unravel the mechanisms contributing to exercise intolerance, examining both central (cardiac) and peripheral (vascular and skeletal muscle) factors. His studies explore these dynamics at rest and in response to acute and chronic physiological and pharmacological stressors and interventions. Ultimately, Dr. Samuel seeks to translate these findings into effective therapeutic strategies for improving patient outcomes.

Google Scholar - Publications

https://scholar.google.com/citations?user=3XDKLuwAAAAJ&hl=en&oi=ao

PubMed - Publications

https://www.ncbi.nlm.nih.gov/myncbi/thomas.samuel.1/bibliography/public/

Selected Publications

• Samuel TJ, Lai S, Schär M, Wu K, Steinberg AM, Wei A-C, Anderson ME, Tomaselli GF, Gerstenblith G, Bottomley PA, Weiss RG. (2022) Myocardial ATP depletion detected noninvasively predicts sudden cardiac death risk in patients with heart failure, JCI Insight, 7 (12): e157557. DOI: 10.1172/jci.insight.157557.
• Samuel TJ, Wei J, Sharif B, Tamarappoo BK, Pattisapu V, Maughan J, Cipher DJ, Suppogu N, Aldiwani H, Thomson LEJ, Shufelt C, Berman DS, Li D, Bairey Merz CN, Nelson MD. (2021) Diastolic dysfunction in women with ischemia and no obstructive coronary artery disease: Mechanistic insight from magnetic resonance imaging, Int J Cardiol, 331: 1-7. DOI: 10.1016/j.ijcard.2021.01.064.
• Samuel TJ, Oneglia AP, Cipher DJ, Ezekowitz JA, Dyck JRB, Anderson T, Howlett JG, Paterson DI, Thompson RB, Nelson MD. (2023) Integration of longitudinal and circumferential strain predicts volumetric change across the cardiac cycle and differentiates patients along the heart failure continuum, J Cardiovasc Magn Reson, 25 (1): 55. DOI: 10.1186/s12968-023-00969-2.
• Lewsey SC, Samuel TJ, Schär M, Sourdon J, Goldenberg JR, Yanek LR, Lai S, Afeworke Y, Steinberg AM,  Bottomley PA, Gerstenblith G, Weiss RG (2025) Skeletal Muscle Quantity versus Quality in Heart Failure: Exercise intolerance and outcomes in older patients with HFpEF are related to abnormal skeletal muscle metabolism rather than age-related skeletal muscle loss, Circ Heart Fail, e012512. DOI: 10.1161/CIRCHEARTFAILURE.124.012512.
• Samuel TJ, Beaudry R, Sarma S, Zaha V, Haykowsky MJ, Nelson MD. (2018) Diastolic Stress Testing Along the Heart Failure Continuum, Curr Heart Fail Rep, 15 (6): 332-339. DOI: 10.1007/s11897-018-0409-5.