Styliani Karanika, MD

Assistant Professor of Medicine

• Johns Hopkins Team Develops Therapeutic, Nasally Delivered DNA Vaccine for Tuberculosis, UNMC (April 1, 2026)
• Johns Hopkins Team Develops Therapeutic, Nasally Delivered DNA Vaccine for Tuberculosis, Hopkins Medicine (April 01, 2026)
• Intranasal DNA Vaccine Targets Drug-Resistant Tuberculosis. Technology Networks Biopharma, (April 2, 2026)
• Johns Hopkins Scientists Develop Nasal DNA Vaccine for Tuberculosis, SciTechDaily (April 7, 2026)
• Detailing the effects of a new therapeutic tuberculosis vaccine!, Journal Clinical Investigation, Instagram (April 7, 2026)
• Detailing the effects of a new therapeutic tuberculosis vaccine! Journal Clinical Investigation, [@jclinicalinvest] X (April 7, 2026)
• Johns Hopkins Team Develops Therapeutic, Nasally-Delivered DNA Vaccine for Tuberculosis, Good News Network (April 8, 2026)
• Tuberculosis vaccine shows promise as once-fatal disease evades treatment, Baltimore Sun (April 14, 2026)
• Our intranasal DNA fusion vaccine helped infected mice clear the disease bacteria faster, reduced lung inflammation, and prevented relapse after treatment ended, The Baltimore Sun, [@baltimoresun], X (April 14, 2026)
• Tuberculosis vaccine shows promise as once-fatal disease evades treatment, Detroit News (April 14, 2026) 
• Infectious disease specialist Styliani Karanika discusses new tuberculosis treatment that shows promise. Hopkins Med News [@HopkinsMedicine], X (April 17, 2026)
• Tuberculosis vaccine shows promise as once-fatal disease evades treatment, Seattle Times (April 24, 2026) 
• Baltimore Lab’s Nose-Spray TB Shot Zaps Infection In Mice, Hoodline (April 24, 2026)

Immunology, Tuberculosis, HIV, Vaccines, host-directed therapies

https://www.ncbi.nlm.nih.gov/myncbi/styliani.karanika.2/bibliography/public/

• Karanika S, Wang T, Yilma A, Castillo JR, Gordy JT, Bailey H, Quijada D, Fessler K, Tasneen R, Rouse Salcido EM, Harris HT, Bates RE, Ton H, Meza J, Li Y, Taylor AD, Zheng JJ, Zhang J, Peske JD, Karantanos T, Maxwell AR, Nuermberger E, Markham RB, Karakousis PC. Immunotherapy targeting drug-tolerant Mycobacterium tuberculosis persisters accelerates tuberculosis cure in preclinical models. J Clin Invest. 2026 Feb 3:e196648. PMID: 41632540
• Karanika S, Gordy JT, Neupane P, Karantanos T, Ruelas Castillo J, Quijada D, Comstock K, Sandhu AK, Kapoor AR, Hui Y, Ayeh SK, Tasneen R, Krug S, Danchik C, Wang T, Schill C, Markham RB, Karakousis PC. An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis. Front Immunol. 2022 Sep 16;13:972266. doi: 10.3389/fimmu.2022.972266. eCollection 2022. PMID: 36189260
• Wang T, Quijada D, Ahmenda T, Castillo JR, Naji NS, Peske JD, Karakousis PC, Paul S, Karantanos T, Karanika S. Targeting CCRL2 enhances therapeutic outcomes in a tuberculosis mouse model. Front Immunol 2025 Mar 20:16:1501329. PMID: 40181978
• Karanika S, Karantanos T, Arvanitis M, Grigoras C, Mylonakis E. Fecal Colonization With Extended-spectrum Beta-lactamase-Producing Enterobacteriaceae and Risk Factors Among Healthy Individuals: A Systematic Review and Metaanalysis. Clin Infect Dis. 2016 Aug 1;63(3):310-8. doi: 10.1093/cid/ciw283. Epub 2016 May 3. PMID: 27143671
• Karanika S, Karantanos T, Li L, Wang J, Park S, Yang G, Zuo X, Song JH, Maity SN, Manyam GC, Broom B, Aparicio AM, Gallick GE, Troncoso P, Corn PG, Navone N, Zhang W, Li S, Thompson TC. Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling. Cell Rep. 2017 Feb 21;18(8):1970-1981. doi: 10.1016/j.celrep.2017.01.072. PMID: 28228262

• Willowcroft Foundation Grant, 6/30/2024
• Gilead's Research Scholar Program HIV Award, Gilead, 3/1/24
• K08, Mentored Clinical Scientist Development Award, NIH/NIAID, 12/11/23
• JHU Center for AIDS Research (CFAR) Faculty Development Award, Johns Hopkins University, 7/1/23
• JHU Tuberculosis Research Advancement Center (TRAC) Developmental Award, Johns Hopkins University, 1/1/23
• Clinician Scientist Award, Johns Hopkins University-School of Medicine, 7/1/22
• Potts Memorial Foundation grant, The Potts Memorial Foundation, 7/1/22