Steven Zeiler, MD, PhD

Professional Titles

• Director, Vascular Neurology Fellowship Program

Primary Academic Title

Associate Professor of Neurology

Background

Centers and Institutes

• Cerebrovascular Center
• Stroke Center at The Johns Hopkins Hospital

Clinical Trials Summary

To learn more about our current cerebrovascular clinical trials, please visit The Johns Hopkins Institute for Clinical and Translational Research (ICTR) and enter "cerebrovascular" in the search box.

Videos

Super Room for Enriched Neurological Repair at Green Spring Station (SENRG)

Recent News Articles and Media Coverage

Research Interests

Stroke recovery

Lab Website

The Zeiler Stroke Recovery Laboratory - Lab Website

• Dr. Zeiler has created a multi-modal set of three research endeavors aimed at testing stroke outcomes during the time period of heightened recovery. These projects are based on mechanisms known to measure and influence brain plasticity, and investigation of these areas holds promise for more complete recovery in stroke patients. 

  Ultra-High Field MRI Study of Brain Reorganization after Stroke
  Using specialized MRI techniques, Dr. Zeiler’s team studies how brain reorganization evolves after stroke and interacts with training. This will allow a targeted understanding of where and when the brain adapts to and recovers from stroke. 

  Nutritional Modification and Enhanced Stroke Recovery
  Dr. Zeiler’s team is modeling a lack of recovery in animals who undergo delayed training after stroke (which has previously been shown to lead to poor motor recovery) and is investigating caloric restriction, which has been shown to enhance brain plasticity and can restore improvement in recovery.

  Medicines and Enhanced Stroke Recovery
  The team is modeling a lack of recovery in animals who undergo delayed training after stroke and is testing the effects of both fluoxetine and Cerebrolysin® on restoring the recovery phase.

Research Summary

Principal investigator, Johns Hopkins Department of Neurology 2010 to present
Assessment of post-stroke neocortical plasticity using a multi-modal approach in the motor and visual cortices.

Postdoctoral fellowship, University of Colorado at Boulder 2002 to 2003
Advisor: Kevin Jones, Ph.D
Title: Brain Derived Neurotrophic Factor Signaling in Murine Visual Cortex.
Continuing upon my thesis research, I further described part of the biochemical signaling pathway through which brain derived neurotrophic factor signals to influence visual cortical plasticity.

Thesis project research, University of Colorado at Boulder 1998 to 2002
Advisor: Kevin Jones, Ph.D
Using genetic knockout mouse technology, I characterized the requirements for brain derived neurotrophic factor in the development and plastic changes of murine visual cortex.

Eleanor Roosevelt Institute 1998
Adviosr: Kathleen Gardiner, Ph.D.
Using several different computer algorithms, I annotated genes on chromosomes 21 and 22 and subsequently validated gene godels using reverse transcriptase-polymerase chain reaction and sequencing techniques. I also analyzed the 3’ untranslated regions of the glutamate receptor family.

Undergraduate research, University of Colorado at Boulder 1995 to 1996
Advisor: William B. Wood, Ph.D.
I studied P granules, organelles asymmetrically segregated during early development of the C. elegans embryo, via cloning, characterization, and genetic mapping of a gene likely to be a P granule component.

PubMed - Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=zeiler%2C+steven

Selected Publications

• Zeiler, S. R., Krakauer, J.W. The interaction between training and plasticity in the poststroke brain. Curr Opin Neurol. Curr Opin Neurol. 2013 Oct 16. [Epub ahead of print]

  Zeiler, S. R., Gibson, E. M., Hoesch, R. E., Li, M. Y., Worley, P. F., O’Brien, R. J., Krakauer, J. W. Medial Premotor Cortex Shows A Reduction In Inhibitory Markers And Mediates Recovery In A Mouse Model Of Focal Stroke. Stroke. 2013 Feb;44(2):483-9.

  Han, Y., Li, N., Zeiler, S. R., Pelled, G. Peripheral nerve injury results in immediate increases in lamina V neuronal activity. (in press). Neurorehabilitation and Neural Repair.

  Qiao, Y., Zeiler, S. R., Mirbagheri, S., Leigh R., Urrutia, V., Wityk, R., Wasserman, B. A., Intracranial Plaque Enhancement in Patients with Cerebrovascular Events: Initial Results using 3D High Resolution Vessel Wall MRI. (epub – ahed of print) Radiology.

  Zeiler, S. R., Gorski, J. A., Jones, K. R. (in revision for European J.Neurosci) BDNF acts as an activity dependent survival and modification factor for visual cortical synapses.

  Marshall, S. A., Zeiler, S. R., Nyquist, P. A. The Use of Permissive Hypercapnia in the setting of Hypoxic Ischemic Encephalopathy and ARDS: a brief case discussion regarding the use of lung protective ventilation in the setting of anoxic brain injury and eventual patient outcome. In preparation for The Neurologist.

  Chik, Y, Gottesman R. F., Zeiler S. R., Rosenberg, J., Llinas R. H. Differentiation of Transverse Sinus Thrombosis From Congenitally Atretic Cerebral Transverse Sinus With CT. Stroke. 2012 Jul;43(7):1968-70. Epub 2012 May 15

  Marsh, E.B., Zeiler, S.R., Levy, M., Llinas, R.H., Urrutia, V.C. Diagnosing CNS Vasculitis: the case against empiric treatment. Neurologist. 2012 Jul;18(4):233-8.

  Qiao Y., Etesami M., Astor B.C., Zeiler S.R., Trout H.H. 3rd, Wasserman B.A. Carotid Plaque Neovascularization and Hemorrhage Detected by MR Imaging are Associated with Recent Cerebrovascular Ischemic Events. Am J Neuroradiol. 2012 Apr;33(4):755-60. Epub 2011 Dec 22.

  Zeiler, S. R., Turtzo, C.L., Kaplan, P. W. SPECT Negative SIRPIDs Mimicking a Stroke After Cardiac Arrest. J Clin Neurophysiol. 2011 Oct;28(5):493-6.

  Zeiler, S. R., Jordan, J. D., Greenberg, B. M., Kaplan, P. K. ANNA-3 Associated Stiff-Person-Syndrome. J. Cancer and Science Therapy. 2009 Vol. 2 Issue 1; 1 – 2.

  Zeiler, S. R., Kaplan, P. W. Our digital world: camera phones and the diagnosis of a seizure. Lancet. 2009 Jun 20;373(9681):2136.

  Zeiler S. R., Kaplan P. W. (2008) Propofol withdrawal seizures (or not). Seizure. 2008 Oct;17(7):665-7. Epub 2008 May 14

  Gorski J. A., Zeiler S. R., Tamowski S., Jones K. R. (2003). Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci. Jul 30;23(17):6856-65.

  Akbarian, S., Rios, M., Liu, R-J., Gold, S., Fongl, H., Zeiler, S., Coppola, V., Tessarollo, L., Jones, K., Nestler, E. J., Aghajanian, G. K., Jaenisch, R. (2002). Brain-Derived Neurotrophic Factor is Essential for Opiate-Induced Plasticity of Noradrenergic Neurons. J Neurosci. May 15;22 (10):4153-62.

  Bennett J. L., Zeiler S. R., Jones K. R. (1999). Patterned expression of BDNF and NT-3 in the retina and anterior segment of the developing mammalian eye. Invest Ophthalmol Vis Sci, Nov;40(12):2996-3005

  Read the latest research papers that Dr. Zeiler has published at PubMed.

Honors

• Osler Housestaff Teaching Award, 1/1/12
• Teaching Excellence Award, Johns Hopkins University Medical Student Award, 1/1/11
• DeFord Teaching Excellence Award, Johns Hopkins Neurology Residency, 1/1/11
• Jay Slotkin Research Award, 1/1/09
• Guy McKhann teaching Award, 1/1/09
• Fellow Scholarship, Annual American Neurological Association Meeting, 1/1/09
• Resident Scholarship, Annual American Academy of Neurology Meeting, 1/1/09
• Osler Housestaff Teaching Award, 1/1/08
• American Academy of Neurology Extended Neuroscience Award, 1/1/05
• Junior and Senior Alpha Omega Alpha (AOA) Medical Honors Society, 1/1/04
• Jahnigen Award, 1/1/03
• Rocky Mountain Neuroscience Conference Annual Student Achievement Award, 1/1/01
• Academic Excellence Award, University of Colorado, 1/1/97
• Summa Cum Laude, 1/1/96
• Mortar Board, 1/1/95
• Phi Beta Kappa, 1/1/95
• Golden Key National Honor Society, 1/1/94
• Dean''s Scholar and Scholarship, 1/1/94
• Alpha Epsilon Delta Honors Society, 1/1/93
• University of Colorado Kittredge Honors Award, 1/1/93
• Kittredge Honors Scholarship, 1/1/93
• National Science Scholar and Scholarship, 1/1/92
• Kittredge Honors Program, 1/1/92

Lectures & Presentations

• Interaction between post-stroke plasticity, rehabilitation, and functional recovery; from rodents to humans., Winter Conference on Neuroplasticity, Peurtro Rico, 1/1/14
• Stroke and Vasculitis; How to Help, How to Harm. Medical Grand Rounds, Good Samaritan Hospital, Baltimore, 1/1/13
• Stroke and Vasculitis; How to Help, How to Harm. Neuroscience Grand Rounds., Greater Baltimore Medical Center, Baltimore, 1/1/13
• Stroke and Vasculitis; How to Help, How to Harm. Neurovascular Case Review (division of Neuro-Interventional Surgery)., Christiana Care Hospital, Newark, 1/1/13
• The Importance of Mouse Medial Premotor Cortex, Early Re-Training, and Fluoxetine In The Recovery From a Focal Stroke Induced Motor Deficit., Platform presentation at Translational and Motor Control Satellite, New Orleans, 1/1/12
• Timing, Training, and Biological Determinants of Post-Stroke Recovery., West Virginia University, Department of Neurology Grand Rounds, West Virginia, 1/1/14
• Timing, Training, and Biological Determinants of Post-Stroke Recovery., Johns Hopkins, Department of Neurology Grand Rounds, Baltimore, 1/1/13
• Timing, Training, and Biological Determinants of Post-Stroke Recovery., Good Samaritan Hospital, Department of Medicine Grand Rounds, Baltimore, 1/1/13

Memberships

• American Academy of Neurology
• American Heart Association
• Society for Neuroscience, Member
• Student Interest Group in Neurology (S.I.G.N), President