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Stephen J. Meltzer

Stephen J. Meltzer, MD

Gastroenterology

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Highlights

Age Groups Seen

  • Young Adult 18-25
  • Adult 26-64
  • Older Adult 65+

Languages

  • German
  • French
  • English

Gender

Male

Johns Hopkins Affiliations:

  • Johns Hopkins School of Medicine Faculty

About Stephen J. Meltzer

Primary Academic Title

Professor of Medicine

Johns Hopkins Physician

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Background

Dr. Stephen J. Meltzer is a Professor of Medicine and Oncology at Johns Hopkins University, Division of Gastroenterology. He is the Director of GI Early Detection Biomarkers Laboratory and a member of the Johns Hopkins Kimmel Cancer Center. His research interests are Gastrointestinal cancer and precancer biomarker discover, development and validation; genomics, epigenomics and bioinformatics, early detection of cancer, outcomes research in cancer and precancer, risk stratification prediction in cancer and precancer, Barrett's esophagus, inflammatory bowel disease-associated cancer, liver cancer and gastric cancer. After receiving degree in Medicine at the State University of New York Medical School, Dr. Meltzer interned at Tulane University in New Orleans and University of Texas Medical Branch in Galveston, TX. He completed his fellowship training program in the University of Colorado and the Lenox Hill Hospital. He was an Assistant Professor in UCLA, Center for Health Science in 1987. Prior to joining the faculty at Johns Hopkins in 2006, he was Professor of Medicine and Pharmacology, Founder and Head of Aero digestive Cancer/Biomarker Program in School of Medicine, University of Maryland at Baltimore. He is an Associate Editor of Cancer Research and a member of the editorial board of Esophageal. He has published 152 original scientific papers in high-impact scientific journals. He also has 43 chapters, review articles, editorials, or letters to the editor; 1 book; and 139 abstracts to his name. He has given a plethora of invited lectures around the world, all involving his principal field of esophageal and gastrointestinal cancer research. He has been the recipient of numerous prestigious national and international awards, including the Robert and Sally D. Funderburg Award in Gastric Cancer Biology and membership in the American Society for Clinical Investigation.

Special Interests: Gastrointestinal cancer and precancer biomarker discover, development and validation; genomics, epigenomics and bioinformatics, early detection of cancer, outcomes research in cancer and precancer, risk stratification prediction in cancer and precancer. Barrett's esophagus, inflammatory bowel disease-associated cancer, liver cancer, gastric cancer

Recent News Articles and Media Coverage

  • Johns Hopkins Developing New Test for Esophageal Cancer, Inside Tract (Spring 2019)

    Trouble on Line-1, Inside Tract (Winter 2016)

Additional Academic Titles

Professor of Oncology

Research Interests

Molecular pathophysiology and translational research in Barrett’s esophagus-associated neoplastic progression

Lab Website

GI Biomarkers Laboratory - Lab Website

  • The GI Biomarkers Laboratory studies gastrointestinal cancer and pre-cancer biogenesis and biomarkers. The lab is led by Dr. Stephen Meltzer, who is known for his research in the molecular pathobiology of gastrointestinal malignancy and premalignancy. Research in the lab has led to several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the gastrointestinal research paradaigm toward genome-wide approaches.

Selected Publications

  • Generation and multiomic profiling of a TP53/CDKN2A double-knockout gastroesophageal junction organoid model

    HUA ZHAO, YULAN CHENG, ANDREW KALRA, KE MA, YUEYUAN ZHENG, BENJAMIN ZIMAN, CAITLIN TRESSLER, KRISTINE GLUNDE, EUN JI SHIN, SAOWANEE NGAMRUENGPHONG, MOUEN KHASHAB, VIKESH SINGH, ROBERT A. ANDERS, SIMRAN JIT, NICOLAS WYHS, WEI CHEN, XU LI, DE-CHEN LIN, AND STEPHEN J. MELTZER 

    SCIENCE TRANSLATIONAL MEDICINE, 30 Nov 2022 Vol 14, Issue 673

    DOI: 10.1126/scitranslmed.abq6146

    https://www.science.org/stoken/author-tokens/ST-900/full

  • Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma K Kawakami, J Brabender, RV Lord, S Groshen, BD Greenwald, ... Journal of the National Cancer Institute 92 (22), 1805-1811

  • Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas KT Wilson, S Fu, KS Ramanujam, SJ Meltzer Cancer Research 58 (14), 2929-2934

  • Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. RF Souza, R Appel, J Yin, S Wang, KN Smolinski, JM Abraham, TT Zou, ... Nature genetics 14 (3), 255

  • PTEN1 is frequently mutated in primary endometrial carcinomas D Kong, A Suzuki, TT Zou, A Sakurada, LW Kemp, S Wakatsuki, ...Nature genetics 17 (2), 143-144

Lectures & Presentations

American Cancer Society Clinical Research Professor

The Harry & Betty Myerberg/Thomas R. Hendrix Professor of Gastroenterology

Locations

  1. Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville
    • 2360 West Joppa Road, Joppa Concourse STE 205, Lutherville, MD 21093
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Expertise

Education

  • Fellowship: Lenox Hill Hospital, Gastroenterology, 1985
  • Fellowship: University of Colorado Anschutz, Gastroenterology, 1984
  • Residency: University of Texas Medical Branch Galveston, Internal Medicine, 1982
  • Medical Education: Buffalo Niagara Medical Center, MD, 1979

Board Certifications

  • Gastroenterology: American Board of Internal Medicine, 1985
  • Internal Medicine: American Board of Internal Medicine, 1982

Insurance

Search plans
  • Aetna
  • CareFirst
  • Cigna
  • First Health
  • Geisinger Health Plan
  • HealthSmart/Accel
  • Johns Hopkins Health Plans
  • MultiPlan
  • Pennsylvania's Preferred Health Networks (PPHN)
  • Point Comfort Underwriters
  • Private Healthcare Systems (PHCS)
  • Veteran Affairs Community Care Network (Optum-VACCN)