Shiv Saidha, MBBCh, MD

Primary Academic Title

Professor of Neurology

Background

Centers and Institutes

The Johns Hopkins Precision Medicine Center of Excellence for Multiple Sclerosis

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Videos

• FY22 Multiple Sclerosis, Myelitis and Myelopathies, and Neuromyelitis Optica Research Update

Research Summary

Dr. Saidha's research interests to date have predominantly focused on the non-invasive interrogation of retinal structures using optical coherence tomography (OCT) in multiple sclerosis (MS), in order to identify and investigate novel outcome strategies for assessing and monitoring neuroprotection and neurorestoration in MS, as well as to further our understanding of the pathobiology of MS, including how retinal pathology in MS may be related to more global central nervous system disturbances. He has been at the fore of discovering and demonstrating that inner and outer retinal layer pathology occur within the unmyelinated retina in MS (both quantitatively and qualitatively). He is committed to continuing to delineate and ascertain the mechanisms involved in the development of these findings, the clinical relevance of these changes (both locally in the retina, as well as more globally), and determine if this information may be used to guide the development of new, and potentially unique/novel effective MS therapies. His work to date has been primarily structurally focused (both within the retina using OCT, as well as more globally within the central nervous system through the assessment of brain substructure volumes, diffusion tensor imaging & magnetization transfer ratio metrics within specific pathways in MS).

Google Scholar - Publications

https://scholar.google.com/citations?user=eHhn8twAAAAJ&hl=en

Research Gate - Research Profile

https://www.researchgate.net/scientific-contributions/57010653_Shiv_Saidha

Selected Publications

• Liu Y, Carass A, He Y, Antony B, Filippatou A, Saidha S, Solomon S, Calabresi P, Prince J. Layer boundary evolution method for macular OCT layer segmentation. (Biomed Opt Express, 2019 Feb 4;10:1064-1080)

• Murphy O, Kwakyi O, Iftikhar M, Zafar S, Lambe J, Pellegrini N, Sotirchos E, Gonzalez-Caldito N, Ogbuokiri E, Filippatou A, Risher H, Cowley N, Feldman S, Fioravante N, Frohman EM, Frohman T, Balcer L, Prince J, Channa R, Calabresi P, Saidha S. Alterations in the retinal vasculature occur in multiple sclerosis and exhibit novel correlations with disability and visual function measures. (Multiple Sclerosis Journal. 2019 May 16)

• Nguyen J, Rothman A, Caldito N, Avornu A, Ogbuokiri E, Balcer L, Galetta A, Frohman E, Frohman T, Crainiceanu C, Calabresi P, Saidha S. Macular ganglion cell and inner plexiform layer thickness is more strongly associated with visual function in multiple sclerosis than Bruch membrane opening minimum rim width or peripapillary retinal nerve fiber layer thicknesses. (Journal of Neuro-ophthalmology, 2019 Mar 26)

• Nolan R, Liu M, Akhand O, Calabresi P, Paul F, Petzold A, Balk L, Brandt A, Martínez-Lapiscina E, Saidha S, Villoslada P, Al-Hassan A, Behbehani R, Frohman E, Frohman T, Havla J, Hemmer B, Jiang H, Knier B, Korn T, Leocani L, Papadopoulou A, Pisa M, Zimmermann H, Galetta SL, Balcer L; IMSVISUAL Consortium. Optimal Inter-Eye Difference Thresholds by OCT in MS: An International Study. (Annals of Neurology, 2019 Mar 9)

• Rothman A, Murphy O, Fitzgerald K, Button J, Gordon-Lipkin E, Ratchford J, Newsome S, Mowry E, Sotirchos E, Syc-Mazurek S, Nguyen J, Caldito N, Balcer L, Frohman E, Frohman T, Reich D, Crainiceanu C, Saidha S, Calabresi P. Retinal measurements predict 10-year disability in multiple sclerosis. (Annals of Clinical and Translational Neurology, 2019 Jan 19;6:222-232)

Honors

• Awarded ECTRIMS/RIMS 2010 Travel Grant, ECTRIMS/RIMS
• Awarded ECTRIMS/RIMS 2011 Travel Grant, ECTRIMS/RIMS
• Awarded ECTRIMS/RIMS 2012 Travel Grant, ECTRIMS/RIMS
• Awarded Teva Neuroscience 2011 Educational Grant, Teva
• Certified for EDSS examination, Neurostatus
• Medical Director for anaccredited Continuing Medical Education program, Johns Hopkins School of Medicine
• Medical Director for an accredited Continuing Medical Education program, University of Medicine and Dentistry of New Jersey (UMDNJ)
• Director of the Johns Hopkins Neuroimmunology and neurological infections case conference program, Johns Hopkins, 1/7/10
• Prize for best oral presentation by a young investigator at ECTRIMS, Multiple Sclerosis International Federation (MSIF), 1/1/10
• Michael J O' Donnell memorial prize, NUI Galway, 1/1/08

Lectures & Presentations

• A novel retinal phenotype in multiple sclerosis is predictive of inflammatory disease activity and disability progression, ECTRIMS, 10/10/12
• Another patient with A learning disability in decline?, RAMI registrar prize, 11/1/08
• Bilateral brachial neuropathy and an unexpected aortic dissection; A case report, Irish neuromuscular meeting, 5/10/08
• Clinical and radiological disease activity is associated with accelerated rates of retinal ganglion cell layer degeneration in multiple sclerosis, AAN, 4/24/12
• Cross-sectional relationships between retinal segmentation and brain sub-structure volumes in multiple sclerosis, ECTRIMS/ACTRIMS, 10/20/11
• In-vivo assessment of retinal axonal and neuronal integrity & pathology in MS with optical coherence tomography, Neurology Grand Rounds, Zurich University, 12/18/12
• In-vivo assessment of retinal axonal and neuronal integrity in MS with optical coherence tomography, CMSC/ACTRIMS, University of Texas Southwestern, 5/31/12
• Multiple sclerosis presenting with parkinsonism; A case report, Irish neurological association 44th annual meeting, 5/8/08
• Novel optical coherence tomography techniques in MS; Emerging evidence for primary retinal neuronal mechanisms of pathology, Neurology Grand Rounds, 5/16/12
• Optical coherence tomography (OCT) of the eye; A window into the MS disease process, United States Project Restore Board Meeting, 3/30/12
• Optical Coherence Tomography as A Tool for Monitoring Changes and Treatment Effects in MS, New York Academy of Sciences Conference on Imaging Neurodegeneration and repair in MS, 6/15/12
• Peri-procedural neuropathy; A retrospective review, RAMI registrar prize, 11/1/08
• Primary retinal pathology in multiple sclerosis as detected by Optical Coherence Tomography, ECTRIMS, 10/13/10
• Progressive encephalomyelitis with rigidity and autoimmune polyglandular syndrome; A case report, Irish neurological association 42nd annual meeting, 5/11/06
• Retinal neuronal loss in multiple sclerosis; Extending the utility of optical coherence tomography with retinal segmentation, AAN, 4/13/11
• Transverse Myelitis and Acute Motor axonal neuropathy, RAMI registrar prize, 11/1/07

Memberships

• American Academy of Neurology (AAN), Member
• Journal of Neurology, Neurosurgery & Psychiatry (JNNP), Journal of Neurology, European Journal of Neurology, PLoS ONE
• New York Academy of Sciences (NYAS), Member