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Shira G Ziegler

Shira G Ziegler, MD, PhD

Clinical Biochemical GeneticsPediatric Genetics

Accepting New Patients

Highlights

Age Groups Seen

  • Infant 0-2
  • Child 3-12
  • Adolescent 13-17
  • Young Adult 18-25
  • Adult 26-64
  • Older Adult 65+

Languages

  • English

Gender

Female

Johns Hopkins Affiliations:

  • Johns Hopkins School of Medicine Faculty

About Shira G Ziegler

Primary Academic Title

Assistant Professor of Genetic Medicine

Johns Hopkins Physician

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Background

Shira Ziegler, M.D., Ph.D., is an Assistant Professor in the McKusick-Nathans Department of Genetic Medicine and has a long-standing commitment to the diagnosis, management, and treatment of children with rare genetic disorders. She graduated from Oberlin College with highest honors in neuroscience and worked in the National Institutes of Health’s Undiagnosed Diseases Program and Human Genome Research Institute. At the Johns Hopkins University School of Medicine, she completed her medical and graduate studies in the Medical Scientist Training Program and then dual residency training in pediatrics and clinical genetics. She served as the Department of Genetic Medicine chief resident before completing a fellowship in medical biochemical genetics. Her clinical practice focuses on inborn errors of metabolism and undiagnosed and rare disorders of pathological calcification.

Research Summary

Dr. Ziegler’s research leverages rare Mendelian disorders of vascular calcification and the connective tissue to elucidate basic mechanisms and identify pharmacologic and genetic modifiers of disease.

Selected Publications

  1. Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, Chen C, Clark L, Condroyer C, De Marco EV, Dürr A, Eblan MJ, Fahn S, Farrer M, Fung H, Gan-Or Z, Gasser T, Gershoni R, Giladi N, Griffith A, Gurevich T, Januario C, Kropp P, Lang AE, Lee-Chen G, Lesage S, Marder K, Mata IF, Mirelman A, Mitsui J, Mizuta I, Nicoletti G, Oliveira C, Ottman R, Orr-Urtreger A, Pereira LV, Quattrone A, Rogaeva E, Rolfs A, Rosenbaum H, Rozenberg R, Samii A, Sammadar T, Schulte C, Sharma M, Singleton A, Spitz M, Tan E, Tayebi N, Toda T, Troiano A, Tsuji S, Wittstock M, Wolfsberg TG, Wu Y, Zabetian CP, Zhao Y, Ziegler SG. Multicenter meta-analysis of glucocerebrosidase mutations in Parkinson disease. New England Journal of Medicine 2009; 22;361(17):1651-61. PMID: 19846850.
  2. St. Hilaire C*, Ziegler SG*, Markello T*, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum R, Kleta R*, Gahl WA*, Boehm M*. NT5E mutations and arterial calcifications. New England Journal of Medicine 2011; 364(5):432-42. PMID: 21288095. *contributed equally
  3. Ziegler SG, Ferreira CR, MacFarlane EG, Riddle RC, Tomlinson RE, Chew EY, Martin L, Ma CT, Sergienko E, Pinkerton AB, Millan JL, Gahl WA, Dietz HC. Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase. Science Translational Medicine 2017; 7;9(393). PMID: 28592560.
  4. MacFarlane EG, Parker SJ, Shin JY, Kang BE, Ziegler SG, Creamer TJ, Bagirzadeh R, Bedja D, Chen Y, Calderon JF, Weissler K, Frischmeyer-Guerrerio PA, Lindsay ME, Habashi JP, Dietz HC. Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome. Journal of Clinical Investigation 2019; 129(2):659-675. PMID: 30614814.

Graduate Program Affiliations

Human Genetics and Genomics

Locations

  1. Rubenstein Child Health Building
    • 200 North Wolfe Street, Rubenstein BLDG Lower Level, Baltimore, MD 21287
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Expertise

Education

  • Fellowship: Johns Hopkins University School of Medicine, Medical Biochemical Genetics, 2024
  • Fellowship: Johns Hopkins University School of Medicine, Genetics Medicine Fellowship, 2023
  • Residency: Johns Hopkins University School of Medicine, Pediatrics and Medical Genetics, 2022
  • Graduate School: Johns Hopkins University School of Medicine, MD/PhD program, Human Genetics, PhD, 2018
  • Medical Education: Johns Hopkins University School of Medicine, MD, 2018

Board Certifications

  • Medical Biochemical Genetics: American Board of Medical Genetics and Genomics, 2025
  • Clinical Genetics and Genomics: American Board of Medical Genetics and Genomics, 2023
  • Pediatrics: American Board of Pediatrics, 2022