Highlights
Age Groups Seen
- Young Adult 18-25
- Adult 26-64
- Older Adult 65+
Languages
- Spanish
- English
In-Network Plans
View All Accepted Plans (12)Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Samuel Denmeade
Professional Titles
- Director Genitourinary Oncology Division
Primary Academic Title
Professor of Oncology
Johns Hopkins Physician
Background
Dr. Samuel Denmeade is the R. Dale Hughes Professor of Oncology and Urology at the Johns Hopkins University School of Medicine and Director of the Genitourinary Oncology Division for the Johns Hopkins Kimmel Cancer Center. He also has appointments in the Department of Pharmacology and Molecular Sciences and Department of Biomolecular Engineering. His areas of clinical expertise include bladder cancer, kidney cancer, prostate cancer and testicular cancer.
Dr. Denmeade earned his M.D. from the Columbia College of Physicians and Surgeons of Columbia University. He completed his residency at the University of Chicago. He performed a fellowship in oncology at The Johns Hopkins Hospital and a fellowship in medical oncology at the Johns Hopkins University School of Medicine.
His research interests include prostate cancer, bipolar androgen therapy, clinical trials and targeted drug development.
Dr. Denmeade has published over 200 papers in the area of prostate cancer research. He has received extensive funding from the NIH, the Department of Defense Prostate Cancer Research Fund and the Prostate Cancer Foundation. He is the Editor-in-Chief of the medical journal The Prostate.
Centers and Institutes
Clinical Trial Keywords
kidney cancer; bladder cancer; prostate cancer
Clinical Trials Summary
Learn more about clinical trials at the Johns Hopkins Kimmel Cancer Center.
Find a Clinical Trial
View all trials by this principal investigator.
Additional Academic Titles
Professor of Physiology, Pharmacology and Therapeutics, Professor of Urology
Contact for Research Inquiries
201 N. Broadway
Baltimore, MD 21287
Phone: (410) 502-8341
Fax: (410) 367-2668
denmesa@jhmi.edu
Research Interests
Bipolar Androgen Therapy, Hormonal Resistance, Tumor Metabolism, Immunotherapy, Targeted Drug Development, Bladder Cancer, Cancer imaging, Prostate and Renal Cancer, Targeted therapies for cancer
Lab Website
Samuel R. Denmeade Laboratory - Lab Website
- The main research goals of my laboratory are: (1) to identify and study the biology of novel cancer selective targets whose enzymatic function can be exploited for therapeutic and diagnostic purposes; (2) to develop methods to target novel agents for activiation by these cancer selective targets while avoiding or minimizing systemic toxicity; (3) to develop novel agents for imaging cancer sites at earliest stages. To accomplish these objectives the lab has originally focused on the development of prodrugs or protoxins that are inactive when given systemically via the blood and only become activated by tumor or tissue specific proteases present within sites of tumor. Using this approach, we are developing therapies targeted for activation by the serine proteases prostate-specific antigen (PSA), human glandular kallikrein 2 (hK2) and fibroblast activation protein (FAP) as well as the membrane carboxypeptidase prostate-specific membrane antigen (PSMA). One such approach developed in the lab consists of a potent bacterial protoxin that we have reengineered to be selectively activated by PSA within the Prostate. This PSA-activated toxin is currently being tested clinically as treatment for men with recurrent prostate cancer following radiation therapy. In a related approach, a novel peptide-cytotoxin prodrug candidate that is activated by PSMA has been identified and is this prodrug candidate is now entering early phase clinical development. In addition, we have also identified a series of potent inhibitors of PSA that are now under study as drug targeting and imaging agents to be used in the treatment and detection of prostate cancer.
PubMed - Publications
Selected Publications
Denmeade SR, Antonarakis EA, Markowski MC. Bipolar Androgen Therapy (BAT): A Patient’s Guide. Prostate, 2022 May;82(7):753-762
Denmeade SR, Sena LA, Wang H, Antonarakis ES, Markowski MC. Bipolar Androgen Therapy Followed by Androgen Receptor Inhibition as Sequential Therapy for Prostate Cancer. Oncologist. 2023 Apr 7:oyad055
Denmeade SR, Wang H, Agarwal N, Smith DC, Schweizer MT, Stein MN, Assikis V, Twardowski PW, Flaig TW, Szmulewitz RZ, Holzbeierlein JM, Hauke RJ, Sonpavde G, Garcia JA, Hussain A, Sartor O, Mao S, Cao H, Fu W, Wang T, Abdallah R, Lim SJ, Bolejack V, Paller CJ, Carducci MA, Markowski MC, Eisenberger MA, Antonarakis ES. TRANSFORMER: A Randomized Phase II Study Comparing Bipolar Androgen Therapy Versus Enzalutamide in Asymptomatic Men With Castration-Resistant Metastatic Prostate Cancer. J Clin Oncol. 2021 Feb 22:JCO2002759
Schweizer MT, Antonarakis ES, Wang H, Ajiboye AS, Spitz A, Cao H, Luo J, Haffner MC, Yegnasubramanian S, Carducci MA, Eisenberger MA, Isaacs JT, Denmeade SR. Effect of bipolar androgen therapy for asymptomatic men with castrate-resistant prostate cancer: Results from a pilot clinical study. Sci Trans Med. 2014: In Press
Sena LA, Kumar R, Sanin DE, Thompson EA, Rosen DM, Dalrymple SL, Antony L, Yang Y, Gomes-Alexandre C, Hicks JL, Jones T, Bowers KA, Eskra JN, Meyers J, Gupta A, Skaist A, Yegnasubramanian S, Luo J, Brennen WN, Kachhap SK, Antonarakis ES, De Marzo AM, Isaacs JT, Markowski MC, Denmeade SR. Prostate cancer androgen receptor activity dictates efficacy of bipolar androgen therapy through MYC. J Clin Invest. 2022 Dec 1;132(23):e162396
Honors
The Carolyn and Bill Stutt Scholar, Patrick C. Walsh Prostate Cancer Research Fund, 1/1/12
Graduate Program Affiliations
Locations
- Skip Viragh Outpatient Cancer Center
- 201 North Broadway Street, Viragh BLDG 5th FL, Baltimore, MD 21287
- Get Directions
- phone: 410-955-8964
- fax: 410-367-2194
Expertise
Education
- Fellowship: Johns Hopkins University School of Medicine, Oncology, 1997
- Residency: University of Chicago Medicine, Internal Medicine, 1992
- Medical Education: Columbia University in the City of New York, MD, 1989
Board Certifications
- Medical Oncology: American Board of Internal Medicine, 2023
Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
5 out of 5
146 ratings, 60 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 5 out of 5 starsReviewed on 3/18/2026
Dr Denmeade is among the vert best doctors I have ever encountered
- 5 out of 5 starsReviewed on 2/25/2026
Dr Denmeade is the best doctor!
- 5 out of 5 starsReviewed on 2/5/2026
Dr. Denmeade was very professional , friendly, and informative.
- 5 out of 5 starsReviewed on 2/4/2026
Dr. Denmeade is courteous, compassionate, and easy to communicate with. He took time to explain my options. Most importantly, he is a wealth of medical knowledge.
- 5 out of 5 starsReviewed on 2/4/2026
Open minded, friendly and clearly competent
- 4 out of 5 starsReviewed on 1/29/2026
Outstanding oncologist!
- 5 out of 5 starsReviewed on 1/29/2026
I look forward to our visits...I feel that I am fortunate be under the care of Dr Denmeade
- 5 out of 5 starsReviewed on 1/22/2026
Dr Denmeade is outstanding
- 5 out of 5 starsReviewed on 1/22/2026
Provider did an excellent job discussing issues
- 5 out of 5 starsReviewed on 1/15/2026
Informed of my problems and took in my concerns in his recommendations for my care.
- 5 out of 5 starsReviewed on 1/15/2026
Dr Denmeade is the best doctor!
- 4 out of 5 starsReviewed on 1/15/2026
All good
- 5 out of 5 starsReviewed on 1/15/2026
Very professional and knowledgeable
- 5 out of 5 starsReviewed on 1/8/2026
Absolutely the best.
- 5 out of 5 starsReviewed on 1/7/2026
Dr Denmeade, extremely friendly and knowledgable.
- 5 out of 5 starsReviewed on 12/31/2025
Dr Denmeade is a very good listener. My wife was present during our video visit and he answered our questions very well. Dr Denmeade had us both at ease at the end of our visit. He explained future options to us in great detail. It was a very positive experience.
- 5 out of 5 starsReviewed on 12/31/2025
Outstanding
- 5 out of 5 starsReviewed on 12/18/2025
Dr Denmeade is excellent and always has a goal of what's best for me.
- 5 out of 5 starsReviewed on 12/17/2025
Knowledgeable, caring, friendly and good listener.
- 5 out of 5 starsReviewed on 12/17/2025
I really appreciate Dr Denmeade's candor and willingness to lanswer questions and let me have a hand in the decision making process.
- 5 out of 5 starsReviewed on 12/11/2025
Outstanding. Dr Denmeade Is by far the best provider I've met, and that includes my experience as a Healthcare Provider of 43+ years, so I've met many others for comparison.
- 5 out of 5 starsReviewed on 12/11/2025
Dr. Denmeade is the best. Period.
- 5 out of 5 starsReviewed on 12/3/2025
Very skilled with a genuine desire to help me with my problems. One of the best visits I've had with a doctor.
- 5 out of 5 starsReviewed on 12/3/2025
Dr Denmeade is a good listener and is easy to understand.
- 5 out of 5 starsReviewed on 11/26/2025
Very professional and helpful. Dr. Is caring and concerned. Discussed many options and put me at ease.
- 5 out of 5 starsReviewed on 11/13/2025
Dr. Denmeade has a great ""bedside"" manner. Great communicator, and super knowledgeable.
- 5 out of 5 starsReviewed on 11/13/2025
Exceeded expections
- 5 out of 5 starsReviewed on 11/13/2025
Attentive , most friendly and thorough
- 5 out of 5 starsReviewed on 11/12/2025
Excellent doctor
- 5 out of 5 starsReviewed on 11/12/2025
I was very satisfied and am looking forward to my ongoing communication with Dr Denmeade
- 5 out of 5 starsReviewed on 10/23/2025
Excellent
- 5 out of 5 starsReviewed on 10/22/2025
Dr. Denmeade is the BEST doctor! I am so lucky to have him as my oncologist!!!!
- 5 out of 5 starsReviewed on 10/9/2025
I found Dr. DenMeade to be engaging and professional. He was totally responsive to my concerns, and showed a reassuring sense of humor. I liked him very much and would trust his judgment and care.
- 5 out of 5 starsReviewed on 10/2/2025
Dr. Denmeade has treated me for stage 4 prostate cancer for almost 2 years. He has been able to contain it. I don't have much control over my situation, but I am ""doing my very best"" by having him as my provider. That gives me confidence and peace.
- 5 out of 5 starsReviewed on 9/24/2025
Extremely helpful in providing information I need to make health decisions going forward.
- 5 out of 5 starsReviewed on 9/18/2025
The best! He is exceptionally knowledgeable and a research leader to find better treatments. I know that he ALWAYS has my best interest in mind with his recommendations.
- 5 out of 5 starsReviewed on 9/18/2025
Awesome physician! Knowledgeable and great patient skills!
- 5 out of 5 starsReviewed on 9/17/2025
Very good!Helpful and professional person.
- 5 out of 5 starsReviewed on 9/11/2025
The provider is the best, I didn't see the provider the time for my appointment had changed without my knowledge
- 5 out of 5 starsReviewed on 8/21/2025
Dr. Denmeade has an outstanding manner in interacting with me as a patient.
- 5 out of 5 starsReviewed on 8/20/2025
Dr Denmeade is a very good listener and he explains things well.
- 5 out of 5 starsReviewed on 8/7/2025
Dr. Denmeade is amazing. So knowledgeable and generous with his time. It was worth traveling 2,000 miles to talk with him.
- 5 out of 5 starsReviewed on 8/6/2025
The absolute best. My family and I trust him with my life.
- 5 out of 5 starsReviewed on 7/30/2025
Best in the business!
- 5 out of 5 starsReviewed on 7/24/2025
Had all my questions answered
- 5 out of 5 starsReviewed on 7/23/2025
Dr Denmeade is an excellent physician. On top of his game as far as prostate cancer treatments are concerned. Very aware of different treatments & different side effects.
- 5 out of 5 starsReviewed on 7/16/2025
Best ever
- 5 out of 5 starsReviewed on 7/9/2025
Had time to explain things ,no rush
- 5 out of 5 starsReviewed on 7/3/2025
Very knowledgeable
- 5 out of 5 starsReviewed on 6/25/2025
DR. Denmeade is awesome
- 5 out of 5 starsReviewed on 6/18/2025
I am very happy to have Dr Denmeade as my doctor and feel very fortunate to have him care for my condition.
- 5 out of 5 starsReviewed on 6/12/2025
Dr Denmeade is very thorougb and takes the time to explano options
- 5 out of 5 starsReviewed on 6/12/2025
Dr Denmeade is a good communicator and trustworthy
- 5 out of 5 starsReviewed on 6/5/2025
The best
- 5 out of 5 starsReviewed on 6/4/2025
Wish I had been in Dr. Denmeade's care many, many years berfore I reached out to Hopkins, when my condition aggressively returned.
- 5 out of 5 starsReviewed on 5/15/2025
Very pleasant manner.Straight forward and thoughtful .I feel so fortunate to be under Dr Denmeade's care.9
- 5 out of 5 starsReviewed on 4/30/2025
I was very pleased
- 5 out of 5 starsReviewed on 4/24/2025
The best
- 5 out of 5 starsReviewed on 4/24/2025
Dr. Denmeade's expertise and compassion make every visit comfortable and reassuring. I trust his judgment completely and feel fortunate to have found such a dedicated professional.
- 5 out of 5 starsReviewed on 4/24/2025
Dr. Denmeade spent a lot of time with us answering questions and discussing my condition. I feel like he really cares and he's an excellent provider, now we have a plan moving forward.