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Ruizhe Chen

Ruizhe Chen, MS, PhD

Highlights

Languages

  • English

Gender

Male

Johns Hopkins Affiliations:

  • Johns Hopkins School of Medicine Faculty

About Ruizhe Chen

Primary Academic Title

Assistant Professor of Oncology

Background

Ruizhe Chen, Ph.D. is currently a tenure-track faculty at the Division of Quantitative Sciences, under the oncology department of Johns Hopkins University School of Medicine. His main duties include conducting collaborative and methodology research as well as teaching an intro-level R data analysis course. His statistical methodology research mainly focuses on Bayesian statistics, restricted mean survival time, and multivariate count data generation and modeling. For collaborative research, he mainly works with Hopkins' breast cancer study team to develop translational imaging and blood biomarkers for clinical response predictions, as well as design and analyze clinical trials. He's also interested in interdisciplinary research between biostatistics and bioinformatics such as informative missing data pattern discovery and application of zero-inflated count data in high-dimensional settings.

Clinical Trials Summary

Breast Cancer, Sarcoma

Contact for Research Inquiries

550 N Broadway
Suite 1103-H
Baltimore, MD 21205

Research Interests

Bayesian Statistics, Noninferiority Trials, Restricted Mean Survival Time

Selected Publications

  • ​​​​​​Chen, Ruizhe, Yu-Che Chung, Sanjib Basu, and Qian Shi. "Diagnostic Test for Realized Missingness in Mixed-type Data." Sankhya B (2023). https://doi.org/10.1007/s13571-023-00317-5

  • Chen, Ruizhe., Shi, Q., & Demirtas, H. (2025). Multivariate zero-inflated generalised poisson data generation methods for simulating counts of adverse events. Journal of Statistical Computation and Simulation, 1–31. https://doi.org/10.1080/00949655.2025.2588606

  • Chen, Ruizhe, Yu-Che Chung, Beth Kelly, Hannah Moore, Sanjib Basu, Dmitrijs Lvovs, Paul M. Gueguen, and David E. Sanin. "Missing data in single-cell transcriptomes reveals transcriptional shifts." bioRxiv (2025): 2025-08.

  • Chen, Ruizhe, Sanjib Basu, Jeffrey P. Meyers, and Qian Shi. "Conversion of non-inferiority margin from hazard ratio to restricted mean survival time difference using data from multiple historical trials." Statistical Methods in Medical Research (2022): 09622802221102621

Courses & Syllabi

Statistics and Data Analysis Using R, ME.510.707

Honors

Open Source Software Project Fund (FOSSProF) Grant (2024), The Johns Hopkins University Open Source Programs Office (OSPO), February 2024

ASA Biopharmaceutical Section Scholarship Award (2021), American Statistical Association, May 2021

Expertise

Education

  • University of Illinois (Chicago), Ph.D., 2022
  • University of Illinois (Urbana-Champaign), M.S., 2017
  • University of Illinois (Urbana-Champaign), B.S., 2015