Oscar Cingolani, MD

Professional Titles

• Director, Hypertension Program
• Associate Director, Coronary Care Unit
• Osler Internal Medicine Faculty (Thayer Firm)

Primary Academic Title

Associate Professor of Medicine

Background

Centers and Institutes

Heart and Vascular Institute

Clinical Trials Summary

Pricipal Investigator in DREAM Study: Effect of Melatonin in preventing atrial fibrillation in patients undergoing cardiac surgery

Videos

• Resistant Hypertension | FAQ with Oscar Cingolani

Recent News Articles and Media Coverage

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  1- Cingolani OH, Heath J, McDonald M. A Nervous Heart. Circulation. 2014. In press.

  2- Seo K, Rainer PP, Lee DI, Hao S, Bedja D, Birnbaumer L, Cingolani OH, Kass DA. Hyperactive Adverse Mechanical-Stress Responses in Dystrophic Heart are Coupled to TRPC6 and Blocked by cGMP-PKG Modulation. Circ Res. 2014. Jan 21.

  3- Gilotra NA, Chow GV, Cingolani OH. Cardiac amyloidosis presenting with a prolonged QT interval and recurrent polymorphic ventricular tachycardia. Tex Heart Inst J 2013;40(2) 193-5.

  4- Cingolani HE, Perez NG, Cingolani OH, Ennis IL. The Anrep effect: 100 years later. Am J Physiol Heart Circ Physiol. 2013 Jan 15; 304(2):H175-82.

  5- Niu X, Watts VL, Cingolani OH, Sivakumaran V, Leyton-Mange JS, Ellis CL, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Paolocci N, Kass DA, Barouch LA. Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase. J Am Coll Cardiol. 2012 may 29; 59(22) 1979-87.

  6- Tedford RJ, Hassoun PM, Mathai SC, Girgis RE, Russell SD, Thiemann DR, Cingolani OH, Mudd JO, Borlaug BA, Redfield MM, Lederer DJ, Kass DA. Pulmonary Capillary Wedge Pressure Augments Right Ventricle Pulsatile Loading. Circulation. 2011 Nov 30.

  7- Cingolani OH, Kirk JA, Seo K, Koitabashi N, Lee DI, Ramirez-Correa G, Bedja D, Barth AS, Moens AL, Kass DA. Thrombospondin-4 is Required for Stretch-Mediated Contractility Augmentation in Cardiac Muscle. Circ Res. 2011 Oct 27.

  8- Cingolani OH, Kass DA. Pressure-Volume Relation Analysis of Mouse Ventricular Function. Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2198-206.

  9- Cingolani OH, Pérez NG, Ennis IL, Alvarez MC, Mosca SM, Schinella GR, Escudero EM, Cónsole G, Cingolani HE. In vivo key role of reactive oxygen species and NHE-1 activation in determining excessive cardiac hypertrophy. Pflugers Arch. 2011 Nov;462(5):733-43.

  10- Ketlogetswe KS, Aoki J, Traill TA, Cingolani OH. Severe Aortic regurgitation Secondary to Antisynthetase Syndrome. Circulation. 2011 Jul 19;124(3):e40-1.

  11- Cingolani OH, Kaludercic N, Paolocci N. Sexual dimorphism in cardiac norepinephrine spillover: a NET difference. Heart. 2011 Mar;97(5):347-9.

  12- Cingolani OH, Pérez NG, Cingolani HE. Letter by Cingolani et al regarding article, "Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice".

  13- Moens AL, Leyton-Mange JS, Niu X, Yang R, Cingolani O, Arkenbout EK, Champion HC, Bedja D, Gabrielson KL, Chen J, Xia Y, Hale AB, Channon KM, Halushka MK, Barker N, Wuyts FL, Kaminski PM, Wolin MS, Kass DA, Barouch LA. Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoceptor. J Mol Cell Cardiol. 2009 Nov;47(5):576-85.

  14- Maloyan A, Osinska H, Lammerding J, Lee RT, Cingolani OH, Kass DA, Lorenz JN, Robbins J. Biochemical and Mechanical Dysfunction in a Mouse Model of Desmin-Related Myopathy. Circ Res. 2009 Apr 24;104(8):1021-8.

  15- Donato A, Cingolani OH. Lemierre Syndrome. Consultant. April 1, 2008. Vol 48 NO. 4.

  16-Pérez NG, Piaggio MR, Ennis IL, Garciarena CD, Morales C, Escudero EM, Cingolani OH, Chiappe de Cingolani G, Yang XP, Cingolani HE. Phosphodiesterase 5A Inhibition Induces Na+/H+ Exchanger Blockade and Protection Against Myocardial Infarction. Hypertension. 2007 May; 49(5):1095-103.

  17- Cingolani OH. Cardiac Hypertrophy and the Wnt/Frizzled Pathway. Hypertension. 2007; 49:427 [Editorial].

  18- Liu YH, Carretero OA, Cingolani OH, Liao TD, Sun Y, Xu J, Li LY, Pagano PJ, Yang JJ, Yang XP. Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction.Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6): H2616-23.

  19- Yang F, Yang XP, Liu YH, Xu J, Cingolani OH, Rhaleb NE, Carretero OA. Ac-SDKP Reverses Inflammation and Fibrosis in Rats With Heart Failure Post-Myocardial Infarction. Hypertension. 2004 43: 229-236.

  20- Cingolani OH. Yang X-P, Liu Y-H, Carretero OA. Reduction of Cardiac Fibrosis Reduces Systolic Performance Without Affecting Diastolic Function in Hypertensive Rats. Hypertension. 2004 May; 43(5):1067-73.

  21- Di Gennaro F, Cingolani OH, Abbate A, Toblli J, Vilches A. Effect of High Doses of Aspirin on Blood Pressure in Hypertensive Patients Treated with Enalapril. Medicina (Buenos Aires). 2004; 64: 301-305

  22- Cingolani OH. Yang X-P, Cavasin MA, Carretero OA, Increased systolic performance with diastolic dysfunction in adult spontaneously hypertensive rats. Hypertension. 2003; 41: 249-254.

  23- Ridruejo E, Laurini J, Cingolani, OH. Fulminant Hepatic Failure. Atipical Presentation for Congestive Heart Failure. [Span]. Medicina (Buenos Aires) 60: 491-494, 2000.

   

Research Interests

Atrial fibrillation, Cardiac regeneration, Heart Failure, Hypertension, Matricellular Proteins in cardiovascular Diseases.

Honors

• The Magic that Matters Fund Award, Johns Hopkins University, 1/1/13
• The Michel Mirowski Discovery Fund Award, Johns Hopkins University, 1/1/12
• PJ Schafer Memorial Heart research Award, Johns Hopkins University, 1/1/11
• The Council for High Blood Pressure Research Award, American Heart Association, 1/1/03
• The Council for High Blood Pressure Research Award, American Heart Association, 1/1/02

Memberships

• American Heart Association, Member
• Council for High Blood Pressure Research, AHA, Member

Professional Activities

• American Journal of Physiology, Reviewer
• Circulation Research, Reviewer
• Heart, Reviewer
• Hypertension, Reviewer
• Journal of the American College of Cardiology, Reviewer