Mohammad Rezaee, MSc, PhD
Highlights
Languages
- English
Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Mohammad Rezaee
Primary Academic Title
Associate Professor of Radiation Oncology and Molecular Radiation Sciences
Background
Dr. Mohammad Rezaee is an associate professor of radiation oncology and molecular radiation sciences at the Johns Hopkins University School of Medicine. His area of expertise is in medical physics and radiation biophysics.
Upon completion of undergraduate studies in radiological sciences and MSc in medical physics, Dr. Rezaee worked in life sciences industry for 8 years and implemented several industrial projects to validate and modernize various processes in hospitals, biological and pharmaceutical centers. He then completed his PhD study in Radiation Sciences and Biomedical Imaging at the University of Sherbrook in Canada. After graduate studies and postdoctoral training, Dr. Rezaee joined the Medical Physics Residency Program at Princess Margaret Cancer Centre at the University of Toronto and received his clinical certificate in therapeutic physics from Canadian College of Physicists in Medicine (CCPM). He had developed expertise in the field of radiation sciences including physics and biophysics with therapeutic and diagnostic applications during his academic study, postdoctoral and residency training programs.
After completion of his residency, he joined the University Health Network and Acumyn Inc (TECHNA). Dr. Rezaee led Aqua Radiology project, a software platform that automates and unifies all quality assurance activities of medical imaging devices across various medical centers. In 2017, Dr. Rezaee joined the Department of Radiation Oncology and Molecular Radiation Sciences at Johns Hopkins University as a clinical physicist. He has been lead physicist in the brachytherapy program. He is also a member of the Radiation Core and physics advisor of advanced preclinical radiation research at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University. He has invented an orthovoltage x-ray FLASH irradiation system for preclinical laboratory research on small animals and cell cultures. Dr. Rezaee has developed FLASH radiation research program at the Department of Radiation Oncology and Molecular Radiation Sciences at the Johns Hopkins University School of Medicine.
Additional Academic Titles
Assistant Professor of Oncology
Research Interests
Radiation Physics and Biophysics, Medical Physics
Research Summary
My research interests lie in radiation physics and biophysics, with a focus on improving the efficacy of radiation therapy through approaches such as FLASH radiotherapy, high-LET charged particles, radiosensitizers, and Auger-electron–emitting radionuclides. A central theme of my work is understanding the roles of time and space in radiation dosimetry and radiation response. This has led to two major research programs in my laboratory:
1. Ultrahigh dose-rate (FLASH) radiotherapy and spatially fractionated radiotherapy (SFRT) for preclinical studies.
This program includes technology development for mechanistic and translational studies, dosimetric characterization of FLASH RT and SFRT using both measurement and computation (Monte Carlo), elucidation of biophysical and biological mechanisms, and translation into clinical practice.
2. Molecular dosimetry.
This program focuses on the development of biomolecular dosimeters and a novel metric, MoD, to address the limitations of absorbed dose in Gray (Gy) for the biological assessment of radiation effects. Molecular dosimetry quantifies radiation-induced DNA alterations in a cell-free, inanimate DNA dosimeter. The program includes modeling, measurement, and application of this dosimetry concept in medicine and industry.
Selected Publications
M Rezaee, DJ Hunting, L Sanche, (2013). New insights into the mechanism underlying the synergistic action of ionizing radiation with platinum chemotherapeutic drugs: the role of low-energy electrons. International Journal of Radiation Oncology* Biology* Physics 87 (4), 847-853.
M Rezaee, I Iordachita, JW Wong, (2021). Ultrahigh dose-rate (FLASH) x-ray irradiator for pre-clinical laboratory research, Physics in Medicine & Biology 66 (9), 095006.
M Rezaee, L Sanche, DJ Hunting, (2013). Cisplatin enhances the formation of DNA single-and double-strand breaks by hydrated electrons and hydroxyl radicals. Radiation research 179 (3), 323-331.
M Rezaee, P Cloutier, AD Bass, M Michaud, DJ Hunting, L Sanche, (2012). Absolute cross section for low-energy-electron damage to condensed macromolecules: A case study of DNA. Physical Review E 86 (3), 031913.
M Rezaee, RP Hill, DA Jaffray, (2017). The Exploitation of Low-Energy Electrons in Cancer Treatment. Radiation research 188 (2), 123-143.
Patents
An ultra-high (FLASH) dose rate x-ray cabinet system for pre-clinical laboratory radiation research, US2021/055294
Additional Training
- Postdoctoral Fellowship, Radiation Biophysics, University of Sherbrooke, Sherbrooke, QC, Canada (2013)
Expertise
Education
- University of Sherbrooke - Quebec, Ph.D., 2013
- Mashhad University of Medical Sciences, M.Sc., 2001
- Shahid Beheshti University of Medical Sciences - Tehran, B.Sc., 1997