Highlights
Age Groups Seen
- Infant 0-2
- Child 3-12
- Adolescent 13-17
- Young Adult 18-25
- Adult 26-64
- Older Adult 65+
Languages
- English
In-Network Plans
View All Accepted Plans (12)Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Michael J. Polydefkis
Professional Titles
- Director, Cutaneous Nerve Lab
Primary Academic Title
Professor of Neurology
Johns Hopkins Physician
Background
Dr. Michael Polydefkis focuses on neuromuscular diseases, particularly peripheral nerve diseases. He has a special interest in diabetic and HIV-associated peripheral neuropathy. His expertise includes nerve conduction studies, electromyography and nerve, skin and muscle biopsy reading.
Dr. Michael Polydefkis received his medical degree from The Johns Hopkins University School of Medicine. He then became a Howard Hughes Medical Institute research fellow before returning to Johns Hopkins to complete an internship and residency in internal medicine, residency in neurology and a fellowship in neuromuscular diseases.
Centers and Institutes
Find a Clinical Trial
View all trials by this principal investigator.
Research Interests
Clinical trial design and biomarker development, Clinical trials in peripheral neuropathy, Developing treatments for nerve regeneration and neuroprotection in human subjects, Mechanisms of peripheral neuropathies
PubMed - Publications
Honors
- Junior Investigator Award in Diabetic Neuropathy, Peripheral Nerve Society
- Clinician Scientist Award, Johns Hopkins University, USA
- Resident Teaching Award, Johns Hopkins University, USA
Memberships
- American Academy of Neurology
- American Diabetes Association
- American Neurological Association
- Peripheral Nerve Society
- Society for Neuroscience
Locations
- Johns Hopkins Bayview Medical Center
- 4940 Eastern Avenue, Suite 1201, Baltimore, MD 21224
- Get Directions
- phone: 410-550-5624
- fax: 410-550-7694
Expertise
Education
- Fellowship: Johns Hopkins University School of Medicine, Neurology, 2000
- Residency: Johns Hopkins University School of Medicine, Neurology, 1998
- Medical Education: Johns Hopkins University School of Medicine, MD, 1993
Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
4.8 out of 5
72 ratings, 28 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 5 out of 5 starsReviewed on 6/17/2026
Best Provider I have had in 67 years
- 5 out of 5 starsReviewed on 6/17/2026
The best of the best, that is John Hopkins
- 5 out of 5 starsReviewed on 6/16/2026
Excellent
- 5 out of 5 starsReviewed on 6/3/2026
Does an excellent job and seems to really care.
- 5 out of 5 starsReviewed on 5/20/2026
This doctor is above amazing! We were able to share personal experiences that brought us together. He showed incredible insight, compassion, understanding.
- 5 out of 5 starsReviewed on 5/18/2026
He's great
- 5 out of 5 starsReviewed on 5/12/2026
I love Dr Polydefkis. He is the recognized expert in his field without question, but he is a remarkable caring person as well. He is holistic which I find unusual in specialized areas. He very kindly tactfully caused me toConsider how my thinking and emotions might be impacting my health. I am acting accordingly, and am seeking some professional help. He is going above and beyond to see if I can be seen by a specialist in a tangential area which is a very long and hard to get. This has not been my experience in the MedStar system.
- 5 out of 5 starsReviewed on 4/29/2026
Dr. Polydefkis is the miost caring doctor I have ever seen. I would highly recommend him.
- 5 out of 5 starsReviewed on 4/15/2026
Very patient and competent
- 5 out of 5 starsReviewed on 4/7/2026
Dr. Polydefkis was professional, Very knowledgeable, and extremely nice.
- 5 out of 5 starsReviewed on 4/1/2026
Dr Polydefkis is straightforward and reliable
- 5 out of 5 starsReviewed on 3/24/2026
By reputation and credentials Dr Polydefkis is renowned in a field of too few experts. Johns Hopkins is one of few centers of excellence in the country, so I was expecting an extraordinary doctor. Dr Polydefkis was certainly that, but in addition he is an extraordinary compassionate human being.
- 5 out of 5 starsReviewed on 3/4/2026
Dr. Polydefkis was very thorough, remembered every detail during our lengthy appointment, repeated back to me most every concern I had and replied and answered them thoroughly and methodically. I was very impressed and felt he understood my complex case.
- 5 out of 5 starsReviewed on 2/24/2026
Outstanding Doctor
- 5 out of 5 starsReviewed on 2/24/2026
Very good experience
- 5 out of 5 starsReviewed on 2/18/2026
Very thorough education given about my condition
- 5 out of 5 starsReviewed on 2/16/2026
Great!
- 5 out of 5 starsReviewed on 2/10/2026
Dr Polydefkis is a wonderful asset to Hopkins
- 5 out of 5 starsReviewed on 1/12/2026
Great!
- 5 out of 5 starsReviewed on 1/7/2026
Dr. Polydefkis is the best doctor with whom I have ever received care, and he one of best human beings:
- 5 out of 5 starsReviewed on 12/9/2025
He was genuinely pleasant, clearly excellent in his field and answered my questions clearly and succinctly. We discussed my diagnosis and expectations completely.
- 5 out of 5 starsReviewed on 12/9/2025
Excellent
- 5 out of 5 starsReviewed on 11/11/2025
Michael Polydefkis always addresses all my questions. He's very professional and patient listening to me. I know I'm in good hands for my treatment for HATTR Amyloidosis.
- 5 out of 5 starsReviewed on 11/11/2025
Love Dr Polydefkis and [staff]
- 5 out of 5 starsReviewed on 11/5/2025
Good doctor
- 5 out of 5 starsReviewed on 10/28/2025
Outstanding
- 5 out of 5 starsReviewed on 10/15/2025
THIS WAS MY INITIAL VISIT WITH DR. POLYDEFKIS AND HE WAS EXTREMELY THOROUGH. I HAVE BEEN TO MANY DOCTORS AND IT WAS IMPRESSIVE THAT HE WOULD SPEND SO MUCH TIME WITH ME TRYING TO GET ALL OF THE INFORMATION HE NEEDED IN ORDER TO DETERMINE THE DIAGNOSIS. I HAVE FULL CONFIDENCE THAT DR. POLYDEFKIS WILL FIGURE OUT WHAT IS CAUSING MY CHRONIC PAIN/PROBLEMS THAT HAVE BEEN LINGERING FOR MANY YEARS.
- 5 out of 5 starsReviewed on 9/2/2025
Very thorough knowledgeable and exceedingly thoughtful.