Michael G. Goggins, MD

Primary Academic Title

Professor of Pathology

Background

Centers and Institutes

• Sidney Kimmel Comprehensive Cancer Center
• Sol Goldman Pancreatic Cancer Research Center

Clinical Trials Summary

The Cancer of the Pancreas Screening-5 CAPS5)Study

http://clinicaltrials.gov/show/NCT02000089

Find a Clinical Trial

Videos

• Hereditary Pancreatic Cancer - Q&A

Recent News Articles and Media Coverage

• Genetic Testing May Hold Promise in Predicting Pancreatic Cancer, Inside Tract (Fall, 2019)

  New Genetic Clues to Pancreatic Cancer, Clinical Connection (Fall, 2017)

Additional Academic Titles

Professor of Medicine, Professor of Oncology

Research Interests

Early detection of pancreatic cancer, familial pancreatic cancer, markers of pancreatic cancer, pancreatic cancer epigenetics, pancreatic cancer genetics, pancreatic cancer screening

Lab Website

Early Detection of Pancreatic Cancer Laboratory - Lab Website

• In the Pancreatic Cancer Early Detection Laboratory, Dr. Goggins oversees research that focuses on gene expression patterns of pancreatic cancers using microarray technology. The lab is also studying DNA methylation patterns looking for genes that are methylated in pancreatic cancer but not in normal cells.

  The lab has put together a profile of genes that are methylated in pancreatic cancer. Some pancreatic cancers methylate a lot of genes; most appear to methylate only a few genes. The lab is currently directing efforts to identify additional genes methylated in pancreatic cancer using novel techniques, and is studying the role of telomerase in pancreatic cancer and its potential as a marker for early detection.

Research Summary

Dr. Goggins’ current research is focused on discovering new markers of pancreatic adenocarcinoma using genetic, epigenetic and proteomic strategies, characterizing the epigenetic alterations in pancreatic cancers and normal tissues and identifying familial pancreatic cancer susceptibility genes through linkage, genome wide association and candidate gene approaches. Additional epigenetic studies are aimed at determining the functional and clinical significance of aberrant DNA methylation changes in pancreatic cancers.

PubMed - Publications

https://pubmed.ncbi.nlm.nih.gov/?term=goggins+m&sort=date

Selected Publications

• Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman EK, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M: Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium. Gut 2020, 69:7-17. doi: 0.1136/gutjnl-2019-319352. Epub 2019 Oct 31

• Abe T, Blackford AL, Tamura K, Ford M, McCormick P, Chuidian M, Almario JA, Borges M, Lennon AM, Shin EJ, Klein AP, Hruban RH, Canto MI, Goggins M: Deleterious Germline Mutations Are a Risk Factor for Neoplastic Progression Among High-Risk Individuals Undergoing Pancreatic Surveillance. J Clin Oncol 2019, 37:1070-80

• Abe T, Koi C, Kohi S, Song KB, Tamura K, Macgregor-Das A, Kitaoka N, Chuidian M, Ford M, Dbouk M, Borges M, He J, Burkhart R, Wolfgang CL, Klein AP, Eshleman JR, Hruban RH, Canto MI, Goggins M: Gene Variants That Affect Levels of Circulating Tumor Markers Increase Identification of Patients With Pancreatic Cancer. Clin Gastroenterol Hepatol 2020, 18:1161-9.e5. doi: 10.016/j.cgh.2019.10.036. Epub Oct 30

• Blackford AL, Canto MI, Klein AP, Hruban RH, Goggins M: Recent trends in the incidence and survival of Stage 1A Pancreatic Cancer: A Surveillance, Epidemiology, and End Results analysis. J Natl Cancer Inst 2020, 112:1162-9

• Tamura K, Yu J, Hata T, Suenaga M, Shindo K, Abe T, MacGregor-Das A, Borges M, Wolfgang CL, Weiss MJ, He J, Canto MI, Petersen GM, Gallinger S, Syngal S, Brand RE, Rustgi A, Olson SH, Stoffel E, Cote ML, Zogopoulos G, Potash JB, Goes FS, McCombie RW, Zandi PP, Pirooznia M, Kramer M, Parla J, Eshleman JR, Roberts NJ, Hruban RH, Klein AP, Goggins M: Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proc Natl Acad Sci U S A 2018, 115:4767-72

Graduate Program Affiliations

• Pathology

  Pathobiology

Memberships

• European Board of Gastroenterology
• Royal College of Physicians of Ireland