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Michael Arthur Cole

Michael Arthur Cole, MD, DPhil

Medical Oncology

Highlights

Languages

  • English

Gender

Male

Johns Hopkins Affiliations:

  • Johns Hopkins School of Medicine Faculty

About Michael Arthur Cole

Primary Academic Title

Instructor in Medicine

Johns Hopkins Physician

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Background

Dr. Michael Cole is a distinguished graduate of the US Air Force Academy (2006), and as an Alberta Bart Holaday Scholar went on to complete his Doctor of Philosophy in Biochemistry (2010) at University of Oxford under the direction of Prof Paul Wentworth Jr. and Prof Bob Sim. He focused his research on peptide chemistry and acyl group reactivity in thioester-containing proteins such as complement proteins, C3 and C4. He fulfilled his Air Force commitment as a chemist and Assistant Professor of Chemistry at the US Air Force Academy. He came to Johns Hopkins University for medical school in 2014.  Since that time, he has stayed at Johns Hopkins completing his medical degree (2018), internal medicine residency training (2021), and hematology fellowship (2024). In 2024, he joined the Division of Hematology as an Instructor. 

Research Interests

Complement, Coagulation, Platelet Activation

Research Summary

Dr. Cole's research interests primarily revolve around the complement system--its role in diseases and its interactions with coagulation and platelet activation. He has developed novel assays to detect complement activation, particularly in relation to complementopathies such as atypical hemolytic uremic syndrome (aHUS)/Complement-mediated Thrombotic Microangiopathy (CM-TMA) and antiphospholipid antibody syndrome (APS). His ongoing projects include investigating the role the classical and alternative pathways of complement in aHUS/CM-TMA pathogenesis, mechanism of complement activation in antiphospholipid antibody syndrome, and monitoring complement activation in xenotransplantation.

Selected Publications

  1. Cole, M.A.; Ranjan, N.; Gloria F. Gerber, G.F.; Pan, X.Z.; Flores-Guerrero, D.; McNamara, G.; Chaturvedi, S.; Sperati, C.J.; McCrae, K.R.; Brodsky, R.A. (2024) Complement Biosensors Identify a Classical Pathway Stimulus in Complement-Mediated Thrombotic Microangiopathy, Blood, Online Ahead of Print. PMID: 39357054.
  2. Cole, M.A.; Gerber, G.F.; Chaturvedi, S. (2023) Complement biomarkers in the antiphospholipid syndrome - Approaches to quantification and implications for clinical management. Clin Immunol 257, 109828. PMID: 37913840.
  3. Cole, M.A.; Tully, S.E.; Dodds, A.W.; Offer, J.; Boldt, G.E.; Sim, R.B.; Wentworth, Jr.; P.A. (2009) A Chemical Approach to Immunoprotein Engineering: Chemoselective Functionalization of Thioester Proteins in their Native State. ChemBioChem 18, 1340-1343. PMID: 19402090.
  4. Banerjee, S.R.; Kumar, V.; Lisok, A.; Chen, J.; Minn, I.; Brummet, M.; Boinapally, S.; Cole, M.A.; Ngen, E.; Wharram, B.; Bryaton, C.; Hobbs, R.F.; Pomper, M.G. (2019) 177Lu-labeled low-molecular-weight agents for PSMA-targeted radiopharmaceutical therapy. Eur J Nucl Med Mol Imaging 46, 2545-2557. PMID: 31399803.
  5. Yuan, X.; Yu, J.; Gerber, G.; Chaturvedi, S.; Cole, M.A.; Chen, H.; Metjian, A.; Sperati, C.J.; Braunstein, E.M.; Brodsky, R.A. (2020) Ex vivo assays to detect complement activation in complementopathies. Clin Immunol 221, Epub. PMID: 33148511.

Locations

  1. Johns Hopkins Bayview Medical Center
  2. The Johns Hopkins Hospital

Expertise

Education

  • Fellowship: Johns Hopkins University School of Medicine, Hematology and Oncology, 2024
  • Residency: Johns Hopkins University School of Medicine, Internal Medicine, 2021
  • Medical Education: Johns Hopkins University School of Medicine, Medicine, MD, 2018
  • Graduate School: University of Oxford School of Medicine, Doctor of Philosophy, DPhil, 2010

Board Certifications

  • Hematology: American Board of Internal Medicine, 2023
  • Internal Medicine: American Board of Internal Medicine, 2021