Highlights
Age Groups Seen
- Young Adult 18-25
- Adult 26-64
- Older Adult 65+
Languages
- German
- English
In-Network Plans
View All Accepted Plans (12)Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Matthias Holdhoff
Professional Titles
- Co-Director, Brain Cancer Disease Group, Sidney Kimmel Comprehensive Cancer Center
Primary Academic Title
Professor of Oncology
Johns Hopkins Physician
Background
Dr. Matthias Holdhoff is a medical oncologist and co-director of the Brain Cancer Disease Group at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He is a professor of oncology, neurology and neurological surgery at Johns Hopkins University School of Medicine. Dr. Holdhoff’s expertise is in primary brain cancers and central nervous system lymphomas.
He earned his medical degree from Freie Universität Berlin, received his doctorate degree at Charité University Medicine Berlin. Dr. Holdhoff completed residency training in internal medicine at Johns Hopkins Bayview Medical Center, followed by a fellowship in medical oncology at Johns Hopkins Hospital with research training at the Ludwig Center for Cancer Genetics and Therapeutics (Kinzler-Vogelstein lab).
As a clinical investigator in neuro-oncology, his research is focused on novel trials and translational biomarker studies in malignant gliomas and primary central nervous system lymphomas. He has led and contributed to numerous clinical trials, publications and presentations.
Dr. Holdhoff serves as the director of the solid tumor inpatient service at the Sidney Kimmel Comprehensive Cancer Center. He is passionately involved in mentoring and teaching of fellows, residents and students. He is the director of the UCNS-certified neuro-oncology fellowship program at Johns Hopkins, and he is a teaching attending physician for the Osler internal medicine residency program.
Centers and Institutes
Find a Clinical Trial
View all trials by this principal investigator.
Additional Academic Titles
Associate Professor of Neurological Surgery, Professor of Neurology
Research Interests
Clinical Trials in Primary Brain Cancers, Translational Research in Neuro-Oncology
Research Summary
Dr. Holdhoff's research is focused on translational research projects and clinical trials in neuro-oncology. His clinical research is concentrated on early phase therapeutic clinical trials in malignant gliomas, including glioblastomas, as well as in primary central nervous system lymphomas. He is leading or participating in multiple brain cancer trials, including within the Adult Brain Tumor Consortium. In addition, he is working on novel biomarkers to assess response and disease activity, including liquid biopsy approaches, in malignant gliomas and primary central nervous system lymphomas.
PubMed - Publications
Selected Publications
Holdhoff M, Ambady P, Abdelaziz A, Sarai G, Bonekamp D, Blakeley J, Grossman SA, Ye X. High-dose methotrexate with or without rituximab in newly diagnosed primary CNS lymphoma. Neurology. 2014 Jul 15;83(3):235-9. PMID:24928128
Holdhoff M, Guner G, Rodriguez FJ, Hicks JL, Zheng Q, Forman MS, Ye X, Grossman SA, Meeker AK, Heaphy CM, Eberhart CG, De Marzo AM, Arav-Boger R. Absence of Cytomegalovirus in Glioblastoma and Other High-grade Gliomas by Real-time PCR, Immunohistochemistry, and In Situ Hybridization. Clin Cancer Res. 2017 Jun 15;23(12):3150-3157. doi: 10.1158/1078-0432.CCR-16-1490. Epub 2016 Dec 29. PMID: 28034905; PMCID: PMC5474132.
Holdhoff M, Ye X, Piotrowski AF, Strowd RE, Seopaul S, Lu Y, Barker NJ, Sivakumar A, Rodriguez FJ, Grossman SA, Burger PC. The consistency of neuropathological diagnoses in patients undergoing surgery for suspected recurrence of glioblastoma. J Neurooncol. 2019 Jan;141(2):347-354. doi: 10.1007/s11060-018-03037-3. Epub 2018 Nov 9. PMID: 30414096; PMCID: PMC6342857.
Holdhoff M, Ye X, Supko JG, Nabors LB, Desai AS, Walbert T, Lesser GJ, Read WL, Lieberman FS, Lodge MA, Leal J, Fisher JD, Desideri S, Grossman SA, Wahl RL, Schiff D. Timed sequential therapy of the selective T-type calcium channel blocker mibefradil and temozolomide in patients with recurrent high-grade gliomas. Neuro Oncol. 2017 Jun 1;19(6):845-852. doi: 10.1093/neuonc/nox020. PMID: 28371832; PMCID: PMC5464434.
Schreck KC, Ranjan S, Skorupan N, Bettegowda C, Eberhart CG, Ames HM, Holdhoff M. Incidence and clinicopathologic features of H3 K27M mutations in adults with radiographically-determined midline gliomas. J Neurooncol. 2019
Honors
- Member, Miller Coulson Academy of Clinical Excellence
- Leadership Development Program, ASCO
- Director's Teaching Award in Clinical Science, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Merit Award, Conquer Cancer Foundation
- Young Investigator Award, Conquer Cancer Foundation
- Best Bedside Manner Award, Johns Hopkins Bayview Medical Center
- Alumnus, German Academic Scholarship Foundation (Studienstiftung des deutschen Volkes)
Locations
- Skip Viragh Outpatient Cancer Center
- 201 North Broadway Street, Viragh BLDG 5th FL, Baltimore, MD 21287
- Get Directions
- phone: 410-955-8964
- fax: 410-367-2194
- Sibley Memorial Hospital
- 5255 Loughboro Road Northwest, Building B, Washington, DC 20016
- Get Directions
- phone: 202-660-6500
- fax: 202-660-6501
Expertise
Education
- Fellowship: Johns Hopkins University School of Medicine, Medical Oncology, 2010
- Residency: Johns Hopkins Bayview Medical Center, Internal Medicine, 2007
- Medical Education: Charite-Universitaetsmedizin Berlin, MD, 2003
Board Certifications
- Medical Oncology: American Board of Internal Medicine, 2009
- Internal Medicine: American Board of Internal Medicine, 2007
Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
4.9 out of 5
138 ratings, 66 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 4 out of 5 starsReviewed on 3/18/2026
Always explain things in a very easy to understand way.
- 5 out of 5 starsReviewed on 3/18/2026
He is excellent and I am thankful for him.
- 5 out of 5 starsReviewed on 3/16/2026
Dr. Holdhoff has been my oncologist for 5+ years. He has consistently been exceptional.
- 5 out of 5 starsReviewed on 3/12/2026
I've been going to Dr Holdhoff ever since my cancer appeared. In my opinion he is one the best.
- 5 out of 5 starsReviewed on 3/12/2026
Dr Holdhoff who we've known since 2021 it's good human being with a high degree of sensibility and humbleness considering he's a prominent doctor.
- 5 out of 5 starsReviewed on 3/12/2026
I like Dr. Holdhoff for being very courteous and thorough.
- 5 out of 5 starsReviewed on 3/11/2026
Most reassuring - explained options and potential options in a way I was able to understand. Sincere and eager to help.
- 5 out of 5 starsReviewed on 3/5/2026
As has consistently been the case with our visits to John's Hopkins everything was done professionally and with attention to our needs.
- 5 out of 5 starsReviewed on 3/5/2026
The care and the compassion is excellent and always is excellent at John Hopkins. It is absolutely a joy to go to Johns Hopkins. They are wonderful people and the doctors are exceptionally knowledgeable and the best in the world. In my opinion I would like to also thank Dr. Holdhoff for his exceptional and compassionate care And handling everything .
- 5 out of 5 starsReviewed on 3/2/2026
Dr. Holdhoff is a very conscientious and super smart physician. Yet he takes the time to explain things to you in a way you can understand. He always has my best interests at heart.
- 5 out of 5 starsReviewed on 2/25/2026
Wonderful
- 5 out of 5 starsReviewed on 2/23/2026
He is always fantastic
- 5 out of 5 starsReviewed on 2/20/2026
Excellent physician. Keep him as long as you can!
- 5 out of 5 starsReviewed on 2/19/2026
Dr. Holdhoff it's very thorough going over the MRI scans and is sensitive to my needs. He is kind and personable.
- 5 out of 5 starsReviewed on 2/18/2026
Excellent. Totally first class and professional. Would go no other place for my care.
- 5 out of 5 starsReviewed on 1/28/2026
Dr.Holdhoff is the most knowledgeable, humane, empathetic doctor. He is always very well prepared for his visits, he Is on top of all the latest research and best treatment options.
- 5 out of 5 starsReviewed on 1/28/2026
Dr. Holdhoff is very easy to deal with. He is competent and compassionate and I trust him very much
- 5 out of 5 starsReviewed on 1/21/2026
He was amazing, my family and I all loved him as a provider. Did not rush us, explained things very thoroughly with lots of details, and made sure we understood everything. He was very personable, and we felt he had our family's best interests at heart. Would recommend to anyone.
- 5 out of 5 starsReviewed on 1/15/2026
Outstanding provider and team.
- 5 out of 5 starsReviewed on 1/8/2026
Excellent doctor. Very knowledgeable and compassionate.
- 5 out of 5 starsReviewed on 1/8/2026
Excellent care and empathy for myself and family. I'm afraid this could kill me but I'm encouraged by the care I'm receiving by Dr. Holdhoff and [staff] and their teams. I have faith that I will live for decades will the support and care from the Johns Hopkins team.
- 5 out of 5 starsReviewed on 1/5/2026
Very knowledgeable about the topic
- 5 out of 5 starsReviewed on 12/31/2025
Best doctor ever!!!
- 5 out of 5 starsReviewed on 12/29/2025
Fantastic
- 5 out of 5 starsReviewed on 12/29/2025
Excellent doctor who listens intently and explains all the medical terminology for me. He also takes all the time I need to make sure I know the plan of action before I leave
- 5 out of 5 starsReviewed on 12/29/2025
Excellent!
- 5 out of 5 starsReviewed on 12/18/2025
Excellent
- 5 out of 5 starsReviewed on 12/18/2025
Absolutely amazing and kind. He was easy to converse with and gave me hope.
- 5 out of 5 starsReviewed on 12/17/2025
It was very good treatment and everything thanks
- 5 out of 5 starsReviewed on 12/15/2025
Knowledgeable, kind, empathetic.
- 5 out of 5 starsReviewed on 12/11/2025
I am thankful for Dr Holdhoff
- 5 out of 5 starsReviewed on 12/10/2025
Provider, Matthias Holdhoff is ALWAYS a pleasure to see and work with
- 5 out of 5 starsReviewed on 11/24/2025
Very good experience with the doctor's and nurses
- 5 out of 5 starsReviewed on 11/17/2025
Explained conditions and plan well
- 5 out of 5 starsReviewed on 11/17/2025
Dr Holdhoff is exceptional!
- 5 out of 5 starsReviewed on 11/13/2025
He has always been fantastic
- 5 out of 5 starsReviewed on 11/10/2025
Very knowledgeable and friendly
- 5 out of 5 starsReviewed on 11/7/2025
The absolute best
- 5 out of 5 starsReviewed on 11/6/2025
Excellent provider and very willing to discuss any issues related to my brain cancer.
- 5 out of 5 starsReviewed on 10/24/2025
Exceptionally compassionate, thoughtful, and available.
- 5 out of 5 starsReviewed on 10/16/2025
Dr Holdhoff provided a comprehensive yet easy to understand evaluation of my condition
- 5 out of 5 starsReviewed on 10/13/2025
Dr. Holdhoff makes me feel like I'm in excellent care with Johns Hopkins
- 5 out of 5 starsReviewed on 10/6/2025
My Doctor (Dr Holdhoff) is fantastic
- 5 out of 5 starsReviewed on 9/24/2025
I can't thank enough Dr. Holdhoff for his humility, knowledge and kindness. Thank you for seeing a human being in me and finding the best treatment option.
- 5 out of 5 starsReviewed on 9/18/2025
The Doctor was awesome and knowledgeable and answered all my questions
- 5 out of 5 starsReviewed on 9/18/2025
Initial visit with this provider for a second opinion. Very satisfied
- 5 out of 5 starsReviewed on 9/11/2025
Dr. Holdhoff is an excellent oncologist. He's very knowledgeable and compassionate.
- 5 out of 5 starsReviewed on 9/4/2025
Dr. Holdhoff has been great for years!
- 5 out of 5 starsReviewed on 8/25/2025
Dr Holdhoff is the best!
- 5 out of 5 starsReviewed on 8/21/2025
Doctor Holdhoff is a great listener and caring doctor. Providing good input.
- 5 out of 5 starsReviewed on 8/18/2025
Dr Holdhoff is excellent, couldn't have a better Oncologist.
- 5 out of 5 starsReviewed on 8/1/2025
Dr. Matthias Holdhoff is the best professional in his field and I fully trust his judgement.
- 5 out of 5 starsReviewed on 7/28/2025
Provider was excellent.
- 5 out of 5 starsReviewed on 7/25/2025
Dr. Holdhoff has always presented himself with an excellent positive and enaging demeanor.His subject matter expertise is very apparent, yet he is able to walk through treatment options and condition with lay-person ease.
- 5 out of 5 starsReviewed on 7/25/2025
Dr. Holdhoff is an amazing and compassionate Individual. I am More than satisfied With Dr. Holdhoff's Expertise and care. He really is brilliant and so Kind with his patients
- 5 out of 5 starsReviewed on 7/17/2025
My first visit with Dr. Holdhoff and he was wonderful! Very intelligent, and kind
- 5 out of 5 starsReviewed on 7/17/2025
He was awesome and Dr. Holdhoff assistant was great as well
- 5 out of 5 starsReviewed on 7/2/2025
Informative conversation and appreciated that Dr. Holdhoff was able to provide advice on various other centers and providers.
- 5 out of 5 starsReviewed on 6/23/2025
He was incredibly helpful and explained things in a way that was reassuring and easy to understand
- 5 out of 5 starsReviewed on 6/23/2025
Dr Holdhoff is so knowledgeable kind and caring. He truly is joyful of the small steps that I achieve . He is encouraging. He is straightforward with his diagnosis In such a caring way.
- 5 out of 5 starsReviewed on 6/23/2025
Excellent in both expertise and knowledge
- 5 out of 5 starsReviewed on 6/20/2025
Dr. Holdhoff is a fantastic Neurologist. He sees me every six months to check on the growth of my tumor. I have a lot of respect for him.
- 5 out of 5 starsReviewed on 6/19/2025
Excellent.
- 5 out of 5 starsReviewed on 6/19/2025
Respect Dr. Holdhoff
- 5 out of 5 starsReviewed on 6/3/2025
Dr. Holdhoff is an amazing asset to JH, I have a difficult diagnosis and I have the utmost confidence in him.
- 5 out of 5 starsReviewed on 5/14/2025
Every one was on point