Marc Greenberg, PhD

Additional Academic Titles

Joint Appointment in Oncology

Research Interests

Biologically relevant chemical mechanisms of nucleic acid damage and repair, biotechnology, design and characterization of DNA repair enzyme inhibitors and radiosensitizing agents

Selected Publications

• A Minor Groove Binding Copper-Phenanthroline Conjugate Produces Direct Strand Breaks Via -Elimination of 2-Deoxyribonolactone. Bales, B. C.; Pitie, M.; Meunier, B.; Greenberg, M. M. J. Am. Chem. Soc. 2002, 124, 9062.

• A Novel Mechanism for the Formation of Direct Strand Breaks Upon Anaerobic Photolysis of Duplex DNA Containing 5-Bromodeoxyuridine. Cook, G. P.; Greenberg, M. M. J. Am. Chem. Soc. 1996, 118, 10025.

• Rapid DNA-Protein Cross-linking and Strand Scission by an Abasic Site in a Nucleosome Core Particle. Sczepanski, J. T.; Wong, R. S.; McKnight, J. N.; Bowman, G. D.; Greenberg,, M. M. Proc. Natl. Acad. Sci. USA 2010, 107, 22475-22480. (PMC: 3012510)

• Synthesis and Characterization of Oligodeoxynucleotides Containing Formamidopyrimidine Lesions and Nonhydrolyzable Analogues. Haraguchi, K.; Delaney, M. O.; Wiederholt, C. J.; Sambandam, A.; Hantosi, Z.; Greenberg, M. M. J. Am. Chem. Soc. 2002, 124, 3263.

• The 2-Deoxyribonolactone Lesion Produced in DNA by Neocarzinostatin and Other Damaging Agents Forms Cross-Links with the Base-Excision Repair Enzyme Endonuclease III. Hashimoto, M.; Greenberg, M. M.; Kow, Y. W.; Hwang, J.-T.; Cunningham, R. P. J. Am. Chem. Soc. 2001, 123, 3161.