Lisa Christopher-Stine, MD

Professional Titles

• Director, Johns Hopkins Myositis Precision Center of Excellence

Primary Academic Title

Professor of Medicine

Background

Centers and Institutes

Myositis Center

Clinical Trial Keywords

Dermatomyositis, Polymyositis, Inclusion Body Myositis, Inflammatory Myopathy, Necrotizing Myopathy, Statin Myopathy

Find a Clinical Trial

Additional Academic Titles

Professor of Neurology

Contact for Research Inquiries

5200 Eastern Ave
Mason F. Lord Tower Suite 4500
Baltimore, MD 21224

Phone: (410) 550-5969

Research Interests

Dermatomyositis, Polymyositis, Inclusion Body Myositis, Inflammatory Myopathy, Necrotizing Myopathy, Statin Myopathy

Research Summary

Dr. Christopher-Stine’s primary research focus is clinical research pertaining to inflammatory myopathies – specifically describing unique phenotypes, novel therapeutic approaches, and novel disease subsets among patients with inflammatory myopathies. Dr. Christopher-Stine is the principal investigator of a growing cohort of over 3000 patients evaluated clinically for confirmed or suspected muscle disease at the Myositis Center who agree to be part of the Johns Hopkins Myositis Research Registry. Dr. Christopher-Stine and her colleagues made the novel discovery of an autoimmune myopathy closely linked to statins. She has a continued interest in statins and their toxicities toward muscle, both as a direct muscle toxin as well as its contribution to autoimmune muscle injury.

Dr. Christopher-Stine and her team are currently investigating several area of interest regarding the inflammatory myopathies. They are interested in cardiovascular complications in the inflammatory myopathies, the contribution of the skin and gut microbiome to myositis phenotypes, and they remain interested in predicting clinical outcomes. In addition, they have investigated the burden of calcinosis in adult dermatomyositis by patient self-report and utilized novel imaging modalities to examine the extent of calcinosis in these patients. In addition, as patient reported outcomes are growing increasingly important, especially in the context of clinical trials, they are an increasing focus of investigative efforts at the Myositis Center. Specifically, Dr. Christopher-Stine and her team are undertaking an international effort to determine the most appropriate patient-driven outcome measures in the inflammatory myopathies.

Google Scholar - Publications

http://scholar.google.com/scholar?hl=en&q=lisa+christopher-stine&btnG=&as_sdt=1%2C21&as_sdtp=

PubMed - Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=Christopher-Stine+L[Author]

Selected Publications

• 1. 1. Christopher-Stine L, Astor B Petri M, Fine D. Protein:Creatinine Ratio is A Reliable Measure of Proteinuria in Lupus Nephritis. J Rheumatol 2004;31:1557-9.
     2. Kalluri M, Sahn SA, Oddis CV, Gharib, Christopher-Stine, L, Danoff SK, Casciola-Rosen L, Hong G3, Dellaripa PF, Highland KB. Clinical profile of anti-PL-12 autoantibody: Cohort Study and Review of the Literature. Chest. 2009 Jun;135(6):1550-6.
     3. Valiyil R, Hong G, Casciola- Rosen L, Mammen AL, Christopher-Stine, L. Rituximab is an Effective Therapy for Myopathy Associated with Anti-Signal Recognition Particle Antibodies: A Case Series. Arthritis Care Res. 2010 Sep;62(9):1328-34
     4. Christopher-Stine L, Hong G, Casciola-Rosen L, Corse A, Mammen AL. A novel autoantibody recognizing 200 and 100 kDa proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum. 2010 Sep;62(9):2757-66
     5. Mammen AL, Chung T, Christopher-Stine L, Rosen P, Rosen A, Casciola-Rosen LA. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme a reductase (HMGCR) in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 2011 Mar;63(3):713-21.
     6. Petri MA, Kiani AN, Post W, Christopher-Stine L, Magder LS. Lupus Atherosclerosis Prevention Study (LAPS).Ann Rheum Dis. 2011 May;70(5):760-5.
     7. Mammen AL, Gaudet D, Brisson D, Christopher-Stine L, Lloyd TE, Leffell MS, Zachary AA. Increased frequency of DRB1*11:01 in anti-HMG-CoA reductase-associated autoimmune myopathy. Arthritis Care Res. 2012 Aug;64(8):1233-7.
     8. Casciola-Rosen L, Hall JC, Christopher-Stine L, Mammen AL, Rosen A. Isolated elevation of aldolase in the serum of myositis patients: a potential biomarker of damaged early regenerating muscle cells. Clin Exp Rheumatol. 2012 Jul-Aug;30(4):548-53.
     9. Werner JL, Christopher-Stine L, Ghazarian SR, Pak KS, Kus JE, Daya NR, Lloyd TE Mammen AL. Antibody Levels Correlate with Creatine Kinase Levels and Strength in Anti-HMG-CoA Reductase-Associated Autoimmune Myopathy. Arthritis Rheum. 2012 Dec;64(12):4087-93.
     10. Alexanderson H, Del Grande M, Bingham III CO, Orbai AM, Sarver C, Clegg-Smith K, Lundberg IE, Song YW, Christopher-Stine L. Patient Reported outcomes and Adult Patients’ disease experience in the Idiopathic Inflammatory Myopathies. A report from the OMERACT 11 Myositis Special Interest Group. J Rheumatol. 2014 Apr;41(4):792-8.
     11. ENMC Myositis Muscle Biopsy Study Group. 193rd ENMC International workshop pathology diagnosis of idiopathic inflammatory myopathies 30 November – 2 December 2012, Naarden, The Netherlands. Neuromuscular Disorders 2013 (23): 945–951.
     12. Fiorentino DF, Chung LS, Christopher-Stine L, Zaba L, Li S, Mammen AL, Rosen A, Casciola-Rosen L.Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1-gamma. Arthritis Rheum. 2013 Nov;65(11):2954-62.
     13. Sharma K, Orbai AM, Desai D, Cingolani OH, Halushka MK, Christopher-Stine L, Mammen AL, Wu KC, Zakaria S. Brief Report: Antisynthetase Syndrome-Associated Myocarditis. J Card Fail. 2014 Jul 29
     14. Johnson C, Connors GR, Oaks J, Han S, Truong A, Richardson B, Lechtzin N, Mammen AL, Casciola-Rosen L, Christopher-Stine L, Danoff SK. Clinical and pathologic differences in interstitial lung disease based on antisynthetase antibody type. Respir Med. 2014 Sep 18
     15. Christopher-Stine L. Siedner M, Lin J, Haas M, Parekh H, Petri M, Fine DM. Renal Biopsy in Lupus Patients with Low Levels of Proteinuria. J Rheumatol. 2007 Feb;34(2):332-5.
     16. Hall JC, Casciola-Rosen L, Samedy LA, Werner J, Oyoyemi K, Danoff SK, Christopher-Stine L. Anti melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum. Arthritis Care Res. 2013 Aug;65(8):1307-15.
     17. Lloyd TE* , Christopher-Stine L*, Penal-Fernandez I, Tiniakou E, Petri M, Baer A, , Danoff SK, Pak K, Casciola-Rosen L , and Mammen AL  . Cytosolic 5’-nucleotidase 1A is a common target of circulating autoantibodies in several autoimmune diseases; Arthritis Rheum , 2015 Apr 17(Epub)

Courses & Syllabi

• Physical Diagnosis Course, Hahnemann University, 1/1/99 - 12/31/01
• Johns Hopkins University, Johns Hopkins University, 1/1/01 - 12/31/10
• Advanced Ambulatory Clerkship in Musculoskeletal Medicine, Johns Hopkins University, 1/1/04 - 12/31/04
• Pathophysiology; Rheumatic Disease Course, Johns Hopkins University, 1/1/05 - 12/31/09
• Immunology II, Johns Hopkins University, 1/1/10 - 12/31/10
• Colleges Advisory Program Core Faculty, Taussig College, 1/1/12

Honors

• Scholarship Award Recipient, Sexton, 1/1/14
• Leadership Program for Women Faculty, Johns Hopkins University, 1/1/10
• Whos Who in America, Marquis, 1/1/09
• Ken Titus Award for the Best Lecture, Virginia Society of Rheumatologists, 1/1/09
• Castle Connolly Medical Ltd. Americas Top Doctors, 1/1/08
• Who's Who of American Women, Marquis, 1/1/08
• Who's Who in Science and Engineering, Marquis, 1/1/07
• The Golden Stethoscope Award Winner, 1/1/01
• The Golden Stethoscope Award Nominee, 1/1/00
• C. Nelson Davis Award, 1/1/98
• Wyeth-Ayerst Award for Excellence in Infectious Diseases, 1/1/98
• Elizabeth Blackwell Memorial Award to the Outstanding Senior Woman, 1/1/97
• Hahnemann Physicians Society Award, Hahnemann Physicians Society, 1/1/97
• Van Buren O. Hammet Memorial Award Prize, 1/1/97
• William Likoff, M.D. Award, 1/1/97
• Outstanding Performance in Psychiatry, Van Buren O. Hammet Memorial Award, 1/1/97
• Alpha Omega Alpha Honor Society, 1/1/96
• Memorial Scholarship, Alpha Phi Sorority Howell, 1/1/96
• Scholarship, William Goldman Foundation, 1/1/95
• Betty Ford Center Professional-in-Residence participant, 1/1/95
• Phi Beta Kappa Honor Society, 1/1/92

Lectures & Presentations

• "A 55 Year-old Man with Underlying Diabetic Nephropathy Presents with a Rapidly Rising Creatinine,", Speaker, Hahnemann University Hospital Morbidity and Mortality Conference, Philadelphia, PA, 5/1/97
• 21-year-old man with fever, rash, arthritis, and pulmonary lesions, Discussant, Massachusetts General Hospital Grand Rounds, Boston, MA, 6/23/11
• A Novel Autoantibody Against 200/100 kDa Is Associated with a Necrotizing Myopathy, Plenary Speaker, ACR Discovery 2009 Plenary Session, Philadelphia, PA, 10/19/09
• Anti-HMG CoA- Reductase Associated Myopathy: An Illustration of Collaboration, Speaker, National Institute of Health, Bethesda, MD, 5/11/11
• Anti-HMGCoA Reductase- Associated Myopathy: Bedside to Bench and Back, Speaker, Neurology Resident Noon Conference, Baltimore, MD, 2/2/11
• Anti-HMGCoA Reductase- Associated Necrotizing Myopathy : Shaping our Understating of The Inflammatory Myopathies, Speaker, Columbia University College of Physicians and Surgeons Rheumatology Rounds, New York, NY, 10/7/11
• Anti-HMGCoA Reductase- Associated Necrotizing Myopathy: Bedside to Bench and Back, Speaker, Cedars-Cinai Medical Center Rheumatology Grand Rounds, Los Angeles, CA, 4/27/11
• Atorvastatin Does Not Increase Bone Mineral density in SLE, Plenary Speaker, EULAR (European League Against Rheumatism), Barcelona, Spain, 6/15/07
• Atorvastatin Treatment Does Not Reduce Cytokines or Cell Adhesion Molecules in SLE, Speaker, American College of Rheumatology Concurrent Session, Boston, MA, 11/10/07
• Autoimmune Statin-Associated Myopathy- The Plot Thickens, Speaker, SUNY Downstate Medical Center Medical Grand Rounds, Brooklyn, NY, 11/7/13
• Bench to Bedside and Back Again: Autoimmune Statin Myopathy and the Anti-HMGCR Story, Speaker, Karolinska Institutet, Stockholm, Sweden, 9/25/12
• Calcinosis, Speaker, ACR Stater of the Art Clinical Symposium, Chicago, IL, 4/29/12
• Cardiovascular Complications of SLE, Speaker, Maryland Lupus Foundation, Baltimore, MD, 11/9/02
• Clinicopathologic Conference, Speaker, Hahnemann University Hospital Grand Rounds, Philadelphia, PA, 6/1/01
• Coping with Prednisone, Speaker, The Myositis Association Annual Conference, Denver, CO, 9/20/08
• Creating a Center of Excellence, Speaker, Your Academic Clinical Practice Toolkit Maximizing Your Success Seminar, Johns Hopkins Hospital, Baltimore, MD, 8/3/15
• Dermatomyositis, Speaker, Johns Hopkins University Grand Rounds, Baltimore, MD, 10/13/05
• Dermatomyositis Treatment, Speaker, ACR Stater of the Art Clinical Symposium, Chicago, IL, 4/29/12
• Difficult Myositis: challenging Idiopathic Inflammatory Myopathy Cases, Speaker, Annual Meeting, South Carolina Rheumatism Society, Charleston, SC, 4/26/15
• Does Bankruptcy Influence Medical Education?, Speaker, MCP Hospital Medicine Grand Rounds, Philadelphia, PA, 5/1/01
• Healthy Living Despite Myositis, Speaker, The Myositis Association Annual Patient Conference, Louisville, KY, 10/19/13
• Lupus and Cardiovascular Disease, Speaker, Lupus Foundation of Greater Washington, Baltimore, MD, 10/4/03
• Management of Interstitial Lung Disease in Myositis, Speaker, Annual Meeting Update on Management and Classification of Myositis Clinical Science Session, European League Against Rheumatism, Paris, France, 6/14/14
• Management of Women with Fibromyalgia and Chronic Fatigue Syndrome, Speaker, Women's Health Symposium, Baltimore, MD, 12/4/03
• Managing your disease (polymyositis), Speaker, The Myositis Association Annual Conference, Denver, CO, 9/20/08
• Myositis 101, Speaker, Kansas City Southwest Clinical Society, Kansas City, MO, 11/5/09
• Myositis 101: A Clinical Review of the Diagnosis and Treatment of Inflammatory Myopathies and their Mimics, Speaker, Monmouth Medical Center - Department of Internal Medicine Medical Grand Rounds, Monmouth, NJ, 10/9/08
• Myositis 101: A Physician's Primer, Speaker, MedStart Harbor Hospital Grand Rounds, Baltimore, MD, 11/20/09
• Myositis 101: Polymyositis, Dermatomyositis, and Related Inflammatory Myopathies, Speaker, Annual Conference, Rheuamtology Nurses Society, Louisville, KY, 8/8/14
• Myositis Mimics, Speaker, Harvard, MA, Boston, MA, 11/8/13
• Myositis Patient Reported Outcomes, Moderator, The Lung in Myositits, Stockholm, Sweden, 5/9/15
• Myositis Patient Reported Outcomes, Speaker, The First International Conference on Myositis, Stockholm, Sweden, 5/11/15
• Myositis Update, Speaker, Advances in the Diagnosis and Treatment of the Rheumatic Diseases, Baltimore, MD, 6/4/10
• Myositis Update, Speaker, Johns Hopkins 10th Annual Advances in the Diagnosis and Treatment of the Rheumatic Diseases, Baltimore, MD, 4/12/14
• Myositis Update: Many Shapes and Sizes, Speaker, North Carolina Rheumatology Association, Carey, NC, 10/17/10
• Myositis Update: Then and Now, Speaker, Medical Grand Rounds, St. Joseph's Medical Center Medica, Baltimore, MD, 5/6/15
• Myositis: 32 Flavors and Then Some, Speaker, Virginia Society of Rheumatolgists, Hot Springs, VA, 9/29/08
• Myositis: A Review, Speaker, Johns Hopkins University Neurology, Baltimore, MD, 11/11/09
• Patient Reported Outcomes in the Idiopathic Inflammatory Myopathies, Speaker/Discussant, OMERACT Special Interest Group, Budapest, Hungary, 5/9/14
• Polymyositis and Dermatomyositis: Recognition and Treatment, Speaker, Rheumatology Symposium, Baltimore, MD, 1/16/05
• Promising Research in PM and DM, Speaker, Annual Patient Conference, The Myositis Association, Reno, NV, 9/6/14
• Stain Myopathy in Evolution:Exploring the Link to Autoimmunity, Speaker, Mount Sinai Beth Israel Medical Grand Rounds, New York, NY, 4/15/14
• Statin Myopathy, Speaker/Discussant, European Neuromuscular Centre (ENMC) 193rd meeting, Naarden, Netherlands, 12/1/12
• Statin Myopathies, Speakers, American College of Rheumatology Annual Scientific Meeting, Chicago, IL, 11/8/11
• Statin Myopathy, Speaker, 2012 Cutting Edge Rheumatology, Stockholm, Sweden, 9/27/12
• Statin Myopathy Associated with Anti-HMGCR Autoantibodies, Speaker, Strategic Advisory Meeting, Inova Diagnostics, Boston, MA, 4/14/15
• Statin Myopathy in Evolution: Immune Mediated Necrotizing Myopathy and the Anti-HMGCR Connection, Keynote Speaker, Philadelphia Rheumatism Society Annual Scientific Lecture, Philadelphia, PA, 5/1/12
• Statin Myopathy in Evolution: When is It Autoimmune?, Speaker, Henry Ford Health System Grand Rounds, Detroit, MI, 10/18/12
• Statin Myopathy: An Autoimmune disease?, Speaker, Center for Autoimmune Disease Research - The Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 6/6/14
• Statin Myopathy: An Autoimmune Disease?, Speaker, Medical Grand Rounds, LSU Health Science Center, New Orleans, LA, 8/29/14
• Statin Myopathy: When is it Autoimmune?, Speaker, Rheumatology Grand Rounds, University of Chicago, Chicago, IL, 9/16/14
• Statin Myopathy: When is it Autoimmune?, Speaker, Medical Grand Rounds, Beaumont Hospital, Detroit, MI., 4/22/15
• Statin-associated autoimmune myopathy: from bedside to bench and back again, Speaker, Walter Reed National Military Medical Center at Bethesda, Bethesda, MD, 10/17/12
• The ABCs of Myositis, Speaker, University of Rochester Medical Grand Rounds, Rochester, NY, 5/29/14
• The ABCs of Myositis - How antibodies can determine clinical features, Speaker, Florida Society of Rheumatology Annual Meeting, Orlando, FL, 7/20/13
• The Antisynthetase Syndrome, Speaker, Drexel University College, Philadelphia, PA, 11/14/07
• The Antisynthetase Syndrome, Speaker, Children's National Medical Center, Washington DC, 10/13/08
• The Antisynthetase Syndrome, Speaker, Massachusetts General Hospital Rheumatology Grand Rounds, Boston, MA, 1/27/09
• The Elevated CPK - Including Statins, Speaker, 10th Kenneth Austin RheumatologySymposium, Howard University, Washington DC, 4/1/15
• The Ever-Changing World of Statin Myopathies, Speaker, Georgetown University, Washington DC, 3/7/13
• What We Know About Statins and Myositis, Speaker, The Myositis Association Annual Conference, Denver, CO, 9/20/08
• What's new in Myositis: Autoimmune Necrotizing Myopathy - the New Kid on the Block?, Speaker, New York State Rheumatology Association, New York, NY, 5/19/11

Memberships

• Alpha Omega Alpha
• American Medical Women‚Äôs Association
• American Medical Women‚Äôs Association,

  Chapter President

• Philadelphia County Medical Society, Pennsylvania Medical Society
• Philadelphia County Medical Society, Pennsylvania Medical Society,

  Vice Chair

• Maryland Society for The Rheumatic Diseases,

  Member

• American College of Rheumatology,

  Fellow Member

• Maryland Society for the Rheumatic Diseases,

  President

• The Myositis Association Medical Advisory Board,

  Member

• The Myositis Association,

  Chair, The Nominating Committee

Professional Activities

• ACR, Abstract Selection Committee on Myositis and Myopathies, 1/1/06
• College Advisory Program, Advisor
• Departments of Medicine's Task Force on Women's Academic Careers in Medicine, Member
• Departments of Medicine's Task Force on Women's Academic Careers in Medicine, Philanthropy Chair
• Institutional Review Board (IRB 5), Board Member
• Johns Hopkins, WorkLife Advisory Group, 1/1/07
• Johns Hopkins University, Barker Firm Faculty, 1/1/05
• Johns Hopkins University, Intern Selection Sub-committee, 1/1/05
• MCP Hahnemann University, Graduate Medical Education Committee, 1/1/98 - 1/1/01
• MCP Hospital, Pharmacy and Therapeutics Committee, 1/1/00 - 1/1/01
• The Myositis Association, Medical Advisory Board, 1/1/09