Lawrence R. Kleinberg, MD

Professional Titles

• Vice Chair of Clinical Research

Primary Academic Title

Professor of Radiation Oncology and Molecular Radiation Sciences

Background

Centers and Institutes

• Comprehensive Brain Tumor Center
• Esophageal Cancer Program
• Sidney Kimmel Comprehensive Cancer Center

Find a Clinical Trial

Videos

• Meet Our Expert: Dr. Lawrence Kleinberg

• Radiation Oncology for Primary Brain Tumors - What You Need to Know

Additional Academic Titles

Professor of Neurological Surgery, Professor of Oncology

Research Interests

Drug and radiation therapy for esophageal cancer, Improved imaging of brain tumors, Improving therapy for brain metastases, Radiation and drug therapy for primary brain tumors

PubMed - Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=Kleinberg%20L%5BAuthor%5D&cauthor=true&cauthor_uid=16502351

Selected Publications

• Heath, E.I.; Burtness, B.A.; Kleinberg, L.; Salem, R.R.; Yang, S.C.; Heitmiller, R.F.; Canto, M.I.; Knisely, J.P.; Topazian, M.; Montgomery, E.; Tsottles, N.; Pithavala, Y.; Rohmiller, B.; Collier, M.; Forastiere, A.A. Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (mmp) inhibitor prinomastat in patients with esophageal adenocarcinoma. Invest New Drugs. 2006 Mar;24(2):135-140.
  
  Kleinberg, L.; Gibson, M.; Yang, S.; Forastiere, A.A.; Putnam, J.B. Primary Combined Modality Therapy for Esophageal Cancer. Oncology. 2006;20(5):505-511.
  
  Donawho, C.K.; Luo, Y.; Luo, Y.; Penning, T.D.; Bauch, J.L.; Bouska, J.J.; Bontcheva-Diaz, V.D.; Cox, B.F.; DeWeese, T.L.; Dillehay, L.E.; Ferguson, D.C.; Ghoreishi-Haack, N.S.; Grimm, D.R.; Guan, R.; Han, E.K.; Holley-Shanks, R.R.; Hristov, B.; Idler, K.B.; Jarvis, K.; Johnson, E.F.; Kleinberg, L.R.; Klinghofer, V.; Lasko, L.M.; Liu, X.; Marsh, K.C.; McGonigal, T.P.; Meulbroek, J.A.; Olson, A.M.; Palma, J.P.; Rodriguez, L.E.; Shi, Y.; Stavropoulos, J.A.; Tsurutani, A.C.; Zhu, G.D.; Rosenberg, S.H.; Giranda, V.L.; Frost, D.J. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 May 1;13(9):2728-2737.
  
  Gerber, D.E.; Grossman, S.A.; Zeltzman, M.; Parisi, M.A.; Kleinberg, L. The impact of thrombocytopenia from temozolomide and radiation in newly diagnosed adults with high-grade gliomas. Neuro-oncology. 2007 Jan;9(1):47-52.
  
  Kleinberg, L.; Forastiere, A.A. Chemoradiation in the management of esophageal cancer. J Clin Oncol. 2007 Sep 10;25(26):4110-4117.
  
  Kleinberg, L.; Gibson, M.K.; Forastiere, A.A. Chemoradiotherapy for localized esophageal cancer: regimen selection and molecular mechanisms of radiosensitization. Nature clinical practice. 2007 May;4(5):282-294.
  
  Kretschmar, C.; Kleinberg, L.; Greenberg, M.; Burger, P.; Holmes, E.; Wharam, M. Pre-radiation chemotherapy with response-based radiation therapy in children with central nervous system germ cell tumors: a report from the Children''s Oncology Group. Pediatric blood & cancer. 2007 Mar;48(3):285-291.
  
  Lawson, H.C.; Sampath, P.; Bohan, E.; Park, M.C.; Hussain, N.; Olivi, A.; Weingart, J.; Kleinberg, L.; Brem, H. Interstitial chemotherapy for malignant gliomas: the Johns Hopkins experience. Journal of neuro-oncology. 2007 May;83(1):61-70.
  
  Ford, E.; Purger, D.; Tryggestad, E.; McNutt, T.; Christodouleas, J.; Rigamonti, D.; Shokek, O.; Won, S.; Zhou, J.; Lim, M.; Wong, J.; Kleinberg, L. A virtual frame system for stereotactic radiosurgery planning. International journal of radiation oncology, biology, physics. 2008 Nov 15;72(4):1244-1249.
  
  Kleinberg, L.R.; Brock, M.V.; Jagannath, S.B.; Forastiere, A.A. Cancer of the Esophagus. In: Abeloff, M.e.a., editor. 4th Edition ed, Clinical Oncology. New York, NY: Churchill-Livingstone; 2008.
  
  Lin, S.H.; Kleinberg, L.R. Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies. Expert review of anticancer therapy. 2008 Mar;8(3):343-359.
  
  Guss, Z.D.; Batra, S.; Li, G.; Chang, S.D.; Parsa, A.T.; Rigamonti, D.; Kleinberg, L.; Lim, M. Radiosurgery for glomus jugulare: history and recent progress. Neurosurg Focus. 2009 Dec;27(6):E5.
  
  McGirt, M.J.; Than, K.D.; Weingart, J.D.; Chaichana, K.L.; Attenello, F.J.; Olivi, A.; Laterra, J.; Kleinberg, L.R.; Grossman, S.A.; Brem, H.; Quinones-Hinojosa, A. Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme. Journal of neurosurgery. 2009 Mar;110(3):583-588.
  
  Meguid, R.A.; Hooker, C.M.; Taylor, J.T.; Kleinberg, L.R.; Cattaneo, S.M., 2nd; Sussman, M.S.; Yang, S.C.; Heitmiller, R.F.; Forastiere, A.A.; Brock, M.V. Recurrence after neoadjuvant chemoradiation and surgery for esophageal cancer: does the pattern of recurrence differ for patients with complete response and those with partial or no response? J Thorac Cardiovasc Surg. 2009 Dec;138(6):1309-1317.
  
  Frazier, J.L.; Batra, S.; Kapor, S.; Vellimana, A.; Gandhi, R.; Carson, K.A.; Shokek, O.; Lim, M.; Kleinberg, L.; Rigamonti, D. Stereotactic radiosurgery in the management of brain metastases: an institutional retrospective analysis of survival. International journal of radiation oncology, biology, physics. 2010;76(5):1486-1492.
  
  Li, S.; Kleinberg, L.R.; Rigamonti, D.; Wharam, M.D., Jr.; Rashid, A.; Jackson, J.; Djajaputra, D.; He, S.; Creasey, T.; DeWeese, T.L. Clinical results of a pilot study on stereovision-guided stereotactic radiotherapy and intensity modulated radiotherapy. Technol Cancer Res Treat. 2010 Dec;9(6):603-617.
  
  Tryggestad, E.; Christian, M.; Ford, E.; Kut, C.; Le, Y.; Sanguineti, G.; Song, D.Y.; Kleinberg, L. Inter- and Intrafraction Patient Positioning Uncertainties for Intracranial Radiotherapy: A Study of Four Frameless, Thermoplastic Mask-Based Immobilization Strategies Using Daily Cone-Beam CT. Int J Radiat Oncol Biol Phys. 2010 Oct 15.