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Khaled Mahmoud El-Shami

Khaled Mahmoud El-Shami, MBChB, MS, PhD

LeukemiaLymphomaHematologic Malignancy

Accepting New Patients

Highlights

Age Groups Seen

  • Young Adult 18-25
  • Adult 26-64
  • Older Adult 65+

Languages

  • Arabic
  • English

Gender

Male

Johns Hopkins Affiliations:

  • Johns Hopkins School of Medicine Faculty

About Khaled Mahmoud El-Shami

Primary Academic Title

Assistant Professor of Oncology

Johns Hopkins Physician

Logo for Johns Hopkins Physician

Background

Khaled M. El-Shami, M.B.Ch.B., Ph.D., is a medical oncologist at Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital, as well as an assistant professor of oncology in the Division of Hematologic Malignancies at Johns Hopkins University School of Medicine.

Listen to Dr. El-Shami's Cancer Matters podcast episode to learn more about his work.

Dr. El-Shami's clinical interests are in hematologic malignancies, including leukemias, lymphomas and myelomas..

Dr. El-Shami graduated from Alexandria University Faculty of Medicine in Alexandria, Egypt, where he did a residency in the Department of Neurosurgery. He was a Chevening Scholar as a M.S. student in molecular genetics at the University of Sussex in the United Kingdom, as well as a Sam Cohen Windhoek Scholar as a Ph.D. student in cancer immunology at the Weizmann Institute in Israel. Dr. El-Shami also completed a residency in internal medicine at George Washington University School of Medicine, a fellowship in tumor immunology and biology at the National Cancer Institute, and a fellowship in medical oncology at Johns Hopkins University School of Medicine. Dr. El-Shami previously served as faculty at Georgetown University and George Washington University.

Dr. El-Shami has been named a Top Doctor by Washingtonian Magazine for several years.

Dr. El-Shami is a member of the American Association for Advancement of Science, the American Association of Cancer Research, the American Association of Immunologists, the American Society for Gene Therapy and the American Society of Clinical Oncology.

Dr. El-Shami's research focus is on hematologic malignancies, including acute and chronic leukemias, myelodysplastic syndromes, myeloprolifetive neplasms and lymphomas. He has received the National Institutes of Health Clinical Research Scholars Award, an American Medical Association Seed Grant and an American Society of Clinical Oncology Merit Award. 

Recent News Articles and Media Coverage

Research Interests

Lymphomas, Acute Leukemias, Chronic Leukemias, Drug Development in lymphoid Malignancies, Hematologic Malignancies.

Selected Publications

  • El-Shami, K., Oeffinger, K.C., Erb, N.L., Willis, A., Bretsch, J.K., Pratt-Chapman, M.L., Cannady, R.S., Wong, S.L., Rose, J., Barbour, A.L., Stein, K.D., Sharpe, K.B., Brooks, D.D., Cowens-Alvarado, R.L. "American Cancer Society Colorectal Cancer Survivorship Care Guidelines." CA Cancer J Clin. 2015 Nov-Dec;65(6):428-55. doi: 10.3322/caac.21286. Epub 2015 Sep 8. Review.

  • El-Shami, K., Stone, R.M., Smith, B.D. "FLT3 inhibitors in acute myeloid leukemia." Expert Rev Hematol. 2008 Dec;1(2):153-60. doi: 10.1586/17474086.1.2.153. Review.

  • Hossain, A., Rafei, H., Jariwala, A., El-Shami, K. "A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia." Leuk Res Rep. 2017 Jan 24;7:20-22. doi: 10.1016/j.lrr.2017.01.001. eCollection 2017.

  • Parikh, S.A., Kantarjian, H., Schimmer, A., Walsh, W., Asatiani, E., El-Shami, K., Winton, E., Verstovsek, S. "Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis." Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9. doi: 10.3816/CLML.2010.n.059.

  • Zheng, L., Edil, B.H., Soares, K.C., El-Shami, K., Uram, J.N., Judkins, C., Zhang, Z., Onners, B., Laheru, D., Pardoll, D., Jaffee, E.M., Schulick, R.D. "A safety and feasibility study of an allogeneic colon cancer cell vaccine administered with a granulocyte-macrophage colony stimulating factor-producing bystander cell line in patients with metastatic colorectal cancer." Ann Surg Oncol. 2014 Nov;21(12):3931-7. doi: 10.1245/s10434-014-3844-x. Epub 2014 Jun 19.

Honors

  • Top Doctor, Washingtonian Magazine
  • Merit Award, American Society of Clinical Oncology
  • Attending of the Year Award, George Washington University School of Medicine
  • Clinical Research Scholars Award, National Institutes of Health

Memberships

  • American Association for Advancement of Science,

    Member

  • American Association of Cancer Research,

    Member

  • American Association of Immunologists,

    Member

  • American Society for Gene Therapy,

    Member

  • American Society of Clinical Oncology,

    Member

Locations

  1. Sibley Memorial Hospital
    • 5255 Loughboro Road Northwest, Building B, Washington, DC 20016
    • Get Directions

Expertise

Education

  • Fellowship: Johns Hopkins University School of Medicine, Oncology, 2008
  • Residency: The George Washington University School of Medicine, Internal Medicine, 2005
  • Graduate School: Sourasky Medical Center, PhD, 2000
  • Graduate School: University Hospitals Sussex NHS, BioChemistry, MS, 1993
  • Residency: Alexandria University Faculty of Medicine, Surgery, 1992
  • Medical Education: Alexandria University Faculty of Medicine, MBChB MS, 1987

Insurance

Please contact the location directly to confirm your health plan is accepted.
Search plans
  • Aetna
  • CareFirst
  • Cigna
  • First Health
  • Geisinger Health Plan
  • HealthSmart/Accel
  • Johns Hopkins Health Plans
  • MultiPlan
  • Pennsylvania's Preferred Health Networks (PPHN)
  • Point Comfort Underwriters
  • Private Healthcare Systems (PHCS)
  • Veteran Affairs Community Care Network (Optum-VACCN)

Ratings & Reviews

5 out of 5

283 ratings, 131 reviews

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

Overall Rating by Patient
Provider Listened Carefully
Provider Explained Things Clearly
Provider Knew Medical History
Provider Showed Respect
Provider Spent Enough Time
Search reviews
    5 out of 5 stars
    Reviewed on 3/20/2026

    El-Shami is wonderful. He makes me feel ""special"" and is very attentive, supportive and responsive. He seems very knowledgeable so that I am assured that I am getting the best advice possible.

    5 out of 5 stars
    Reviewed on 3/20/2026

    Have seen this Dr for over 5 years-he is super!

    5 out of 5 stars
    Reviewed on 3/20/2026

    Excellent, very knowledgeable and supportive.

    5 out of 5 stars
    Reviewed on 3/17/2026

    Dr El-Shami is the best

    5 out of 5 stars
    Reviewed on 3/16/2026

    Dr El-Shami is the best

    5 out of 5 stars
    Reviewed on 3/10/2026

    Extremely comfortable in meetings with Dr El-Shami.

    5 out of 5 stars
    Reviewed on 3/6/2026

    We like Dr. El-Shami, But sometimes he is hard to reach.

    5 out of 5 stars
    Reviewed on 3/6/2026

    Dr. El-Shami is a kind, caring and knowledgeable provider.

    5 out of 5 stars
    Reviewed on 3/3/2026

    He is simply the best!

    5 out of 5 stars
    Reviewed on 3/3/2026

    Dr. El-Shami is a truly excellent doctor who exhibits care and concern as well as great expertise.

    5 out of 5 stars
    Reviewed on 3/2/2026

    Dr. El-Shami is exceptional. Caring, careful, knowledgeable.

    5 out of 5 stars
    Reviewed on 3/2/2026

    It is a privilege to be a patient of an outstandingPhysician Dr. El-Shami.

    5 out of 5 stars
    Reviewed on 2/27/2026

    I'd say my doctor is the best doctor My doctor again I would pick no one other than him. He looks after me cares for me and I think he really truly cares for me.

    5 out of 5 stars
    Reviewed on 2/24/2026

    This was my first visit with Dr. El-Shami. He was clear, kind, reassuring, and gave me and my wife all the time we needed.

    5 out of 5 stars
    Reviewed on 2/20/2026

    Good service

    5 out of 5 stars
    Reviewed on 2/16/2026

    Dr. El-Shami could not have been more informative, helpful and kind. I feel very fortunate that he is my doctor.

    5 out of 5 stars
    Reviewed on 2/13/2026

    AWESOME

    5 out of 5 stars
    Reviewed on 2/13/2026

    Dr. El-Shami is one of the most lovely gentleman I've ever met. Adding to that is his incredible knowledge and his extremely personable manner.

    5 out of 5 stars
    Reviewed on 2/10/2026

    Excellent provider, very knowledgeable, very communicative and prepared for visit

    5 out of 5 stars
    Reviewed on 2/10/2026

    Dr el-Shami is outstanding, vert thorough, listens well and provides clear explanations and diagnosis.

    5 out of 5 stars
    Reviewed on 2/9/2026

    He is the best and who saved my life

    5 out of 5 stars
    Reviewed on 2/6/2026

    Dr El-Shami is all I could hope for in a provider. Although he is an oncologist dealing with my cancer, he is so helpful, kind, and informative that I always look forward to seeing him.

    5 out of 5 stars
    Reviewed on 2/6/2026

    He is great. Understandable, knowledgeable and reassuring

    5 out of 5 stars
    Reviewed on 2/6/2026

    I've been seeing Dr. El-Shami for sveral years now, after seeing [staff] and [staff] for years before that. He's really excellent in every way, as were [staff] and [staff].

    5 out of 5 stars
    Reviewed on 2/3/2026

    Very thorough. Very good at explaining health issues as well as doing research, reading other health care testing and results that may be a factor in my health care needs.

    5 out of 5 stars
    Reviewed on 2/2/2026

    Dr El-Shami clearly and professionally explained my condition and the course of treatment.

    5 out of 5 stars
    Reviewed on 2/2/2026

    Excellent provider

    5 out of 5 stars
    Reviewed on 2/2/2026

    Excellent / Very Caring, thoughtful and helpful.

    5 out of 5 stars
    Reviewed on 1/30/2026

    First rate and very compassionate

    5 out of 5 stars
    Reviewed on 1/27/2026

    Dr. El- Shami is a national treasure.

    5 out of 5 stars
    Reviewed on 1/27/2026

    Very professional, great personality, went throughly thru my test results.

    5 out of 5 stars
    Reviewed on 1/23/2026

    Dr El-Shami is the best and so Is [staff]

    5 out of 5 stars
    Reviewed on 1/23/2026

    I particularly like Dr El-Shami's positive attitude about any care that I might need. I would like more info and answers to questions that I don't know how to ask as I am curious and smart.

    5 out of 5 stars
    Reviewed on 1/20/2026

    Very supportive and professional

    5 out of 5 stars
    Reviewed on 1/20/2026

    He fit me into his busy scheduled and provided expert, caring advice in dealing with my condition.

    5 out of 5 stars
    Reviewed on 1/16/2026

    Dr. El-Shami is very compassionate, caring and THE BEST

    5 out of 5 stars
    Reviewed on 1/12/2026

    Dr.El-Shami seems genuinely interested in his patients' wellbeing.

    5 out of 5 stars
    Reviewed on 1/9/2026

    Dr. El-Shami is a kind, compassionate and knowledgeable doctor.

    5 out of 5 stars
    Reviewed on 1/5/2026

    He's THE BEST!

    5 out of 5 stars
    Reviewed on 12/29/2025

    Seems very concerned about my health

    5 out of 5 stars
    Reviewed on 12/22/2025

    He encouraged me to keep taking my medicine and taking care of myself. Everyday!

    5 out of 5 stars
    Reviewed on 12/19/2025

    Excellent doctor; easy to talk to, very knowledgable.

    5 out of 5 stars
    Reviewed on 12/19/2025

    He is an excellent doctor, knowledgable, connects, informs and assures. I have confidence and trust in Dr. El-Shami.

    5 out of 5 stars
    Reviewed on 12/19/2025

    Dr El-Shami is excellent and I would highly recommend him.

    5 out of 5 stars
    Reviewed on 12/12/2025

    Dr El-Shami is kind, considerate, friendly and well informed.

    5 out of 5 stars
    Reviewed on 12/12/2025

    AWESOME; He cares for the health and well being of his patients

    5 out of 5 stars
    Reviewed on 12/10/2025

    Great

    5 out of 5 stars
    Reviewed on 12/10/2025

    Dr. El-Shami provided excellent, clear education about my condition. He is an expert in the field. He treated me with respect and kindness.

    5 out of 5 stars
    Reviewed on 12/8/2025

    He is an excellent professional

    5 out of 5 stars
    Reviewed on 12/8/2025

    He's the best, kindest of all. I am undergoing a new drug and El-Shami is very careful about it.

    5 out of 5 stars
    Reviewed on 12/5/2025

    Dr El-Shami is an incredibly compassionate, knowledgeable, and caring doctor. I highly recommend him!

    5 out of 5 stars
    Reviewed on 12/5/2025

    Excellent doctor

    5 out of 5 stars
    Reviewed on 12/3/2025

    Dr El-Shami is wonderful

    5 out of 5 stars
    Reviewed on 12/3/2025

    Dr El-Shami is an extremely likable and well informed hematologist, and very responsive to all my questions and concerns.

    5 out of 5 stars
    Reviewed on 12/1/2025

    Dr el-Shami is outstanding and provides excellent care. As a result I am absolutely my cancer will continue to be in remission.

    4 out of 5 stars
    Reviewed on 11/21/2025

    The best

    5 out of 5 stars
    Reviewed on 11/21/2025

    Awesome

    5 out of 5 stars
    Reviewed on 11/21/2025

    Best and Greatest in the World. There's none like him.

    5 out of 5 stars
    Reviewed on 11/20/2025

    Dr El-Shami is a terrific physician and I feel honored to be in his care

    5 out of 5 stars
    Reviewed on 11/19/2025

    He's the best doctor in Washington, maybe the country.

    5 out of 5 stars
    Reviewed on 11/18/2025

    El-Shami is the most caring doctor I've ever had

    5 out of 5 stars
    Reviewed on 11/17/2025

    Dr El-Shami had been candid and up front about my ongoing cancer treatment. He is pleased with my progress thus far and seems deeply concerned about my well-being.

    5 out of 5 stars
    Reviewed on 11/17/2025

    The very best

    5 out of 5 stars
    Reviewed on 11/14/2025

    Visits always a positive experience.

    5 out of 5 stars
    Reviewed on 11/12/2025

    Dr. El-Shami is the best doctor I ever had!

    5 out of 5 stars
    Reviewed on 11/10/2025

    Always ""Excellent""!

    5 out of 5 stars
    Reviewed on 11/7/2025

    Very informative and seem to care about me

    5 out of 5 stars
    Reviewed on 10/31/2025

    Very knowledgeable and helpful.

    5 out of 5 stars
    Reviewed on 10/31/2025

    Outstanding & Very Professional

    5 out of 5 stars
    Reviewed on 10/20/2025

    Dr. El-Shami is a brilliant doctor with an excellent manner about him. He explains things so that they are easy to understand, interpret blood results line by line and outlines options for any future treatment that may be needed. Exceptional all the way around.

    5 out of 5 stars
    Reviewed on 10/17/2025

    Dr. El-Shami is a caring, knowledgeable and experienced provider. He always takes time to answer my questions.

    5 out of 5 stars
    Reviewed on 10/17/2025

    Dr El-Shami always takes time to go over my test results, showing me graphs which display my results over time on his computer screen. He listens to my concerns and answers my questions and is unfailingly kind and supportive.

    5 out of 5 stars
    Reviewed on 10/15/2025

    I am alive because of Dr El-Shami All my gratitude to him

    5 out of 5 stars
    Reviewed on 10/9/2025

    My doctor is amazing and very knowledgeable about my condition.

    5 out of 5 stars
    Reviewed on 10/6/2025

    Very good

    5 out of 5 stars
    Reviewed on 10/6/2025

    Dr. El-Shami is extraordinary.

    5 out of 5 stars
    Reviewed on 10/6/2025

    He was great Dr El-Shami was the hest

    5 out of 5 stars
    Reviewed on 10/3/2025

    The best !!

    5 out of 5 stars
    Reviewed on 9/26/2025

    He's terrific. His explanation in response to my question was brilliant; tailored to my life and completely clear!

    5 out of 5 stars
    Reviewed on 9/19/2025

    Excellent doctor

    5 out of 5 stars
    Reviewed on 9/12/2025

    Dr El-Shami is outstanding

    5 out of 5 stars
    Reviewed on 9/10/2025

    Helpful

    5 out of 5 stars
    Reviewed on 9/8/2025

    First rate

    5 out of 5 stars
    Reviewed on 9/8/2025

    Doctor El-Shami is an excellent doctor, he explain things very well to me.

    5 out of 5 stars
    Reviewed on 9/4/2025

    Dr. El-Shami is an outstanding professional and caring human being. It is an honor for me to be his patient. He is saving my life.

    5 out of 5 stars
    Reviewed on 9/3/2025

    Excellent & very compassionate physician He is one of the Best in the World""I'm a physician myself and can say that with great confidence .

    5 out of 5 stars
    Reviewed on 9/3/2025

    Dr. ElShami listens to my concerns, responds favorably to my issues, and values my Input as a patient. Dr. ElShami Is concerned about the patient's overall well being. Dr. ElShami Is a wonderful Oncologist and a special human being. Glad I have him for my Oncologist!

    5 out of 5 stars
    Reviewed on 8/27/2025

    Very pleased so far. We've just begun this cancer journey together and Dr. El-Shami is very positive and encouraging that I'll be okay.

    5 out of 5 stars
    Reviewed on 8/25/2025

    Dr El-Shami is the best!!!!

    5 out of 5 stars
    Reviewed on 8/25/2025

    The Best

    5 out of 5 stars
    Reviewed on 8/25/2025

    Excellent care

    5 out of 5 stars
    Reviewed on 8/22/2025

    He is one of the finest doctors jive ever experienced

    5 out of 5 stars
    Reviewed on 8/20/2025

    The doctor was caring and kind. We felt well cared for and confident with this doctor

    5 out of 5 stars
    Reviewed on 8/13/2025

    Dr. El-Shami saved my life and I wouldn't trade his care for anybody.

    5 out of 5 stars
    Reviewed on 8/13/2025

    I've been seeing g Dr. El-Shami for several years now and he's as good as they come. A very caring physician.

    5 out of 5 stars
    Reviewed on 8/11/2025

    Dr El-Shami is a very compassionate doctor, listens to my concerns and is able to address most of them.

    5 out of 5 stars
    Reviewed on 8/11/2025

    Dr El-Shami is both extremely pleasant and knowledgeable

    5 out of 5 stars
    Reviewed on 8/6/2025

    A wonderful doctor. I have the utmost faith in his ability to treat my leukemia

    5 out of 5 stars
    Reviewed on 8/4/2025

    Well prepare and professional.

    5 out of 5 stars
    Reviewed on 7/28/2025

    Dr El-Shami is outstanding, very thorough, educational & compassionate.

    5 out of 5 stars
    Reviewed on 7/25/2025

    He is an amazing and caring Doctor

    5 out of 5 stars
    Reviewed on 7/25/2025

    He's keeping me well.

    5 out of 5 stars
    Reviewed on 7/16/2025

    Dr. El-Shami is the best doctor anyone could ask for.

    5 out of 5 stars
    Reviewed on 7/16/2025

    Dr El-Shami is an excellent Oncologist. Very kind and easy to explain and ask questions . I am still alive because of him. I thank him every day for treating me

    5 out of 5 stars
    Reviewed on 7/16/2025

    I trust Dr. El-Shami .

    5 out of 5 stars
    Reviewed on 7/11/2025

    If not the best, one of the best.

    5 out of 5 stars
    Reviewed on 7/7/2025

    Absolutely and one of her experience with my provider very professional patient and encouraging

    5 out of 5 stars
    Reviewed on 6/27/2025

    Dr. El-Shami is a caring and knowledgeable provider. He always answers questions thoroughly and makes good suggestions to address medication side effects and other concerns.

    5 out of 5 stars
    Reviewed on 6/23/2025

    Terrific doctor very professional and through

    5 out of 5 stars
    Reviewed on 6/23/2025

    Excellent

    5 out of 5 stars
    Reviewed on 6/18/2025

    Very positive about the outcome of treatment.

    5 out of 5 stars
    Reviewed on 6/16/2025

    Dr. El-Shami is wonderful oncologists and genuinely cares about his patients. I have been under his care for two years now and could not be more pleased with his level of care.

    5 out of 5 stars
    Reviewed on 6/12/2025

    Very good. Personable and knowledgeable

    5 out of 5 stars
    Reviewed on 6/11/2025

    Great experience as always.

    5 out of 5 stars
    Reviewed on 5/28/2025

    I feel very fortunate to have Dr El-Shami as my oncologist

    5 out of 5 stars
    Reviewed on 5/28/2025

    Dr. El-Shami is excellent in his particular specialty.

    5 out of 5 stars
    Reviewed on 5/23/2025

    First rate

    5 out of 5 stars
    Reviewed on 5/19/2025

    Excellent, concerned about my health. Easy to talk wirh.

    5 out of 5 stars
    Reviewed on 5/14/2025

    I've been seeing Dr. El-Shami for several years now, and he's really excellent.

    5 out of 5 stars
    Reviewed on 5/14/2025

    Grateful for his expertise and experience and his sensitivity dealing with me.

    5 out of 5 stars
    Reviewed on 5/9/2025

    Dr. El-Shami is the best in every category.

    5 out of 5 stars
    Reviewed on 5/7/2025

    He was and always is very thorough in his explanations of what the tests showed and what the numbers mean

    5 out of 5 stars
    Reviewed on 5/7/2025

    Awesome Doctor

    4 out of 5 stars
    Reviewed on 5/5/2025

    Knowledgeable but wrongly dismissive of symptoms. Doesn't answer some specific questions either because he doesn't know the answer or doesn't want to.

    5 out of 5 stars
    Reviewed on 5/2/2025

    Wonderful doctor who inspires confidence and trust.

    5 out of 5 stars
    Reviewed on 4/30/2025

    Dr. El-Shami is a wonderful doctor. He has taken care of me for over 7 Years, and things have gone very well.

    5 out of 5 stars
    Reviewed on 4/30/2025

    The best there is! I arrived one hour early and my doctor saw me early when he should have been going to lunch. This is truly putting the patient first! A lot of doctors/hospitals talk about it, but Dr El-Shami and Sibley actually do it!

    5 out of 5 stars
    Reviewed on 4/28/2025

    Excellent explanation of my health issues

    5 out of 5 stars
    Reviewed on 4/25/2025

    You are the best. I had stage 4 lymphoma & 6 years later I am cured

    5 out of 5 stars
    Reviewed on 4/18/2025

    Dr El-Shami is excellent and inspires total confidence.

    5 out of 5 stars
    Reviewed on 4/16/2025

    Best in the World