John Sperati, MD, MHS

Professional Titles

• Director, Nephrology Fellowship Training Program

Primary Academic Title

Associate Professor of Medicine

Background

Centers and Institutes

Glomerular Diseases Clinic

Clinical Trial Keywords

FSGS, IgA, minimal change, membranous, aHUS, hemolytic uremic syndrome, C3 glomerulopathy

Clinical Trials Summary

Cure Glomerulopathy (CureGN) 

A multi-center, randomized, double-blind, placebo-controlled, parallel-group, phase III study to evaluate the efficacy and safety of LNP023 in primary IgA nephropathy patients.

A multicenter, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of iptacopan (LNP023) in complement 3 glomerulopathy.

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Contact for Research Inquiries

1830 E. Monument St.
Room 416
Baltimore, MD 21287

Phone: (410) 955-5268
Fax: (410) 367-2258

Research Interests

Thrombotic microangiopathy, atypical hemolytic uremic syndrome, C3 glomerulopathy, IgA nephropathy, glomerular disease, fibromuscular dysplasia

Lab Website

C. John Sperati Lab

• Dr. Sperati's group focuses on complement mediated kidney disorders, glomerular disease, and renal arterial disease secondary to fibromuscular dysplasia. His team has a particular interest in thrombotic microangiopathies involving the complement system.

PubMed - Publications

https://www.ncbi.nlm.nih.gov/myncbi/john.sperati.1/bibliography/public/

Selected Publications

• Amir A Naderi; Brian A Houston; C John Sperati; All wrapped up and nowhere to flow. The American journal of medicine 2012;125(9):876-9. 2012 

• C D Collard; A Väkevä; C Büküsoglu; G Zünd; C J Sperati; S P Colgan; G L Stahl; Reoxygenation of hypoxic human umbilical vein endothelial cells activates the classic complement pathway. Circulation 1997;96(1):326-33. 1997

• C John Sperati; Michael B Streiff; Acute renal failure in a patient with antiphospholipid syndrome and immune thrombocytopenic purpura treated with eltrombopag. American journal of hematology 2010;85(9):724-6. 2010

• C John Sperati; Nada Alachkar; Ronald Rodriguez; Mark Haas; Michael J Choi; Incidental discovery of a renal cell carcinoma on native kidney biopsy. American journal of kidney diseases : the official journal of the National Kidney Foundation 2010;56(1):175-80. 2010

• C John Sperati; Nisha Aggarwal; Aravind Arepally; Mohamed G Atta; Fibromuscular dysplasia. Kidney international 2009;75(3):333-6. 2009 

• C John Sperati; Rulan S Parekh; Yvette Berthier-Schaad; Bernard G Jaar; Laura Plantinga; Nancy Fink; Neil R Powe; Michael W Smith; Josef Coresh; W H Linda Kao; Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patients. American journal of kidney diseases : the official journal of the National Kidney Foundation 2009;53(5):845-55. 2009

• Elizabeth George; Girish N Nadkarni; Michelle M Estrella; Gregory M Lucas; C John Sperati; Mohamed G Atta; Derek M Fine; The impact of hepatitis C coinfection on kidney disease related to human immunodeficiency virus (HIV): a biopsy study. Medicine 2011;90(5):289-95. 2011 

• Foy M, Sperati CJ, Lucas GM, Estrella MM. “Drug interactions and antiretroviral drug monitoring.” Curr HIV/AIDS Rep. 2014 Sep;11(3):212-22. doi: 10.1007/s11904-014-0212-1.

• Gavriilaki E, Yuan X, Ye Z, Ambinder AJ, Shanbhag SP, Streiff MB, Kickler TS, Moliterno AR, Sperati CJ, Brodsky RA. “Modified Ham test for atypical hemolytic uremic syndrome.” Blood. 2015 Jun 4;125(23):3637-46. doi: 10.1182/blood-2015-02-629683. Epub 2015 Apr 10.

• Joshua F Zeidner; Edwin J Ostrin; Emily Sydnor; Derek Fine; C John Sperati; The tissue's the issue. The American journal of medicine 2010;123(5):420-2. 2010

• Michelle M Estrella; Chistopher J Sperati; Wen H L Kao; Rulan S Parekh; Genetic epidemiology of chronic kidney disease. Current opinion in nephrology and hypertension 2010;19(3):283-91. 2010

• Priscilla K Brastianos; Jordan W Swanson; Michael Torbenson; John Sperati; Petros C Karakousis; Tuberculosis-associated haemophagocytic syndrome. The Lancet infectious diseases 2006;6(7):447-54. 2006

• Sayed Tabatabai; C John Sperati; Mohamed G Atta; Kashif Janjua; Christopher Roxbury; Gregory M Lucas; Derek M Fine; Predictors of complication after percutaneous ultrasound-guided kidney biopsy in HIV-infected individuals: possible role of hepatitis C and HIV co-infection. Clinical journal of the American Society of Nephrology : CJASN 2009;4(11):1766-73. 2009

• Sperati CJ, Moliterno AR. “Thrombotic microangiopathy: focus on atypical hemolytic uremic syndrome.” Hematol Oncol Clin North Am. 2015 Jun;29(3):541-59. doi: 10.1016/j.hoc.2015.02.002. Epub 2015 Apr 4.

• Sperati CJ, Whaley-Connell A. “Secondary hypertension: beginnings and transitions.” Adv Chronic Kidney Dis. 2015 May;22(3):177-8. doi: 10.1053/j.ackd.2015.03.001.

• Vernon HJ, Sperati CJ, King JD, et al. “A detailed analysis of methylmalonic acid kinetics during hemodialysis and after combined liver/kidney transplantation in a patient with mut0 methylmalonic academia.” J Inherit Metab Dis. 2014 Nov; 37(6): 899–907. doi:10.1007/s10545-014-9730-7.

Honors

• Fellow, National Kidney Foundation
• Member, Miller Coulson Academy of Clinical Excellence
• Distinguished Educator Award, American Society of Nephrology, 1/1/20

Memberships

• American Society of Nephrology
• National Kidney Foundation

Professional Activities

Osler Medical Residency, Barker Firm Faculty Leader