Jinyuan Zhou, PhD

Professor of Radiology and Radiological Science

Amide proton transfer (APT) MRI, Brain tumor imaging, Chemical exchange saturation transfer (CEST) MRI, Molecular MR imaging, New MR imaging techniques, Stroke pH imaging

Jinyuan Zhou Lab - Lab Website

• Dr. Zhou's research focuses on developing new in vivo MRI and MRS methodologies to study brain function and disease. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, high-resolution diffusion tensor imaging (DTI), magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, and tissue protein MR imaging. Notably, Dr. Zhou and his colleagues invented the amide proton transfer (APT) approach for brain pH imaging and tumor protein imaging. His initial paper on brain pH imaging was published in Nature Medicine in 2003 and his most recent paper on tumor treatment effects was published in Nature Medicine in 2011. A major part of his current research is the pre-clinical and clinical imaging of brain tumors, strokes, and other neurologic disorders using the APT and other novel MRI techniques. The overall goal is to achieve the MRI contrast at the protein and peptide level without injection of exogenous agents and improve the diagnostic capability of MRI and the patient outcomes.

Dr. Zhou's research focuses on developing new methodologies of in vivo magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to study brain function and various human diseases, such as brain tumor and stroke. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, tissue protein MR imaging, and high-resolution diffusion tensor imaging (DTI). A major part of his current research is in vivo imaging of experimental brain tumor models and clinical imaging of brain tumor patients using a new MRI technique, the amide proton transfer (APT) imaging. The overall goal is to achieve the MRI contrast at the protein and peptide level without injection of exogenous agents and to improve the diagnostic capability of MRI and the patient outcome.

http://www.ncbi.nlm.nih.gov/pubmed?cmd=DetailsSearch&term=Jinyuan+Zhou

• Jinyuan Zhou, Erik Tryggestad, Zhibo Wen, Bachchu Lal, Tingting Zhou, Rachel Grossman, Kun Yan, Silun Wang, De-Xue Fu, Jaishri Blakeley, Eric Ford, Betty Tyler, John Laterra, and Peter C.M. van Zijl. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nature Med. 17, 130-134 (2011). PMC3058561

• Jinyuan Zhou, Jean-Francois Payen, David A. Wilson, Richard J. Traystman, and P. C. M. van Zijl. Using the Amide Proton Signals of Intracellular Proteins and Peptides to Detect pH Effects in MRI. Nature Med. 9, 1085-1090 (2003)

• Zhou J, Heo HY, Knutsson L, van Zijl PCM, Jiang S. APT-weighted MRI: Techniques, current neuro applications, and challenging issues. J. Magn. Reson. Imaging. 50, 347-364 (2019). PMC6625919.

• Zhou J, Zaiss M, Knutsson L, Sun PZ, Ahn SS, Aime S, Bachert P, Blakeley JO, Cai K, Chappell MA, Chen M, Gochberg DF, Goerke S, Heo HY, Jiang S, Jin T, Kim SG, Laterra J, Paech D, Pagel MD, Park JE, Reddy R, Sakata A, Sartoretti-Schefer S, Sherry AD, Smith SA, Stanisz GJ, Sundgren PC, Togao O, Vandsburger M, Wen Z, Wu Y, Zhang Y, Zhu W, Zu Z, van Zijl PCM. Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors. Magn. Reson. Med. 88, 546-574 (2022). PMC9321891.

• Jiang S, Eberhart CG, Lim M, Heo HY, Zhang Y, Blair L, Wen Z, Holdhoff M, Lin D, Huang P, Qin H, Quinones-Hinojosa A, Weingart JD, Barker PB, Pomper MG, Laterra J, van Zijl PCM, Blakeley JO, Zhou J. Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy. Clin. Cancer Res. 25, 552-561 (2019). PMC6335169

• August 2022 Issue Editor's Picks, Magn. Reson. Med., 8/1/22
• The most cited papers in 2019 J. Magn. Reson. Imaging, 30th ISMRM Ann. Meeting (Hybrid), 5/7/22
• Fellow, International Society of Magnetic Resonance in Medicine (ISMRM), 5/7/22
• The most cited papers in 2016 J. Magn. Reson. Imaging, 27th ISMRM Ann. Meeting, 5/11/19
• 1st Place Abstract Award in 2017 Radiology Research Day, Department of Radiology, JHU, 5/30/17
• 2nd Place Abstract Award in MR in Drug Development Study Group, 25th ISMRM Ann. Meeting, 4/22/17
• January 2016 Issue Editor's Picks, Magn. Reson. Med., 1/1/16
• Distinguished Investigator Award, The Academy of Radiology Research, 1/1/12
• Award for Scientific Excellence, Division of MR Research, Department of Radiology, Johns Hopkins University, 1/1/03
• Second-Class Natural Science Prize, The Chinese Academy of Sciences, 1/1/97
• First-Class Graduate Scholarship, Wuhan Institute of Physics, 1/1/96
• First-Class Hong Kong Yilida Scholarship, The Chinese Academy of Sciences, 1/1/96
• Outstanding Presidential Scholarship, The Chinese Academy of Sciences, 1/1/96
• Second-Class Graduate Scholarship, Wuhan Institute of Physics, 1/1/95
• Second-Class Young Scientist Award, Tianjuan Wang Foundation, the Chinese Physical Society, 1/1/94

• International Society of Magnetic Resonance in Medicine (ISMRM)
• International Society for Cerebral Blood Flow and Metabolism
• American Association for Cancer Research (AACR)
• Radiological Society of North America (RSNA)
• National Neurotrauma Society (NNS)

In Vivo MRI, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 1999, Fellowship