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Janet M. Siliciano

Janet M. Siliciano, PhD

Highlights

Languages

  • English

Gender

Female

Johns Hopkins Affiliations:

  • Johns Hopkins School of Medicine Faculty

About Janet M. Siliciano

Primary Academic Title

Professor of Medicine

Background

Dr. Janet Siliciano is a Professor of Medicine in the Infectious Diseases Division in the  Department of Medicine at the Johns Hopkins School of Medicine. Her expertise is in the analysis of HIV-1 persistence. Her laboratory has shown that HIV-1 persists in a latent reservoir in resting CD4 T cells and that this reservoir decays very slowly over the first seven years of antiretroviral therapy (ART).  Her recent studies, using several reservoir assays that the lab has developed over the years, have further shown that reservoir decay does not continue after seven years but rather increases with an estimated doubling time of 23 years. This lack of decay was shown to reflect the proliferation of infected CD4+ T cells. These studies reinforce the need for lifelong ART for people living with HIV.  Her current research interests include HIV cure strategies based on more recent findings that autologous neutralizing antibodies to the HIV envelope protein prevent rebound from a substantial but variable fraction of viruses in the latent reservoir.

Dr. Siliciano holds a bachelor’s degree from the University of New Hampshire and a PhD from the Johns Hopkins University School of Medicine. She completed postdoctoral fellowships at Harvard Medical School and the Johns Hopkins University School of Medicine before joining the faculty. 

Lab Website

Janet Siliciano Lab

  • Research in the Janet Siliciano lab focuses on HIV. Areas of study include CD4-positive T lymphocytes, virus latency and highly active antiretrovirals. We recently explored the challenges of detecting HIV persistence during potentially curative interventions and the multifactorial nature of HIV-1 latency.

Selected Publications

  • Christine M Durand; Gabriel Ghiaur; Janet D Siliciano; S Alireza Rabi; Evelyn E Eisele; Maria Salgado; Liang Shan; Jun F Lai; Hao Zhang; Joseph Margolick; et al. HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy. The Journal of infectious diseases 2012;205(6):1014-8.

  • Steven A Yukl; Eli Boritz; Michael Busch; Christopher Bentsen; Tae-Wook Chun; Daniel Douek; Evelyn Eisele; Ashley Haase; Ya-Chi Ho; Gero Hutter; et al. Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient. PLoS pathogens 2013;9(5):e1003347.

  • Susanne Eriksson; Erin H Graf; Viktor Dahl; Matthew C Strain; Steven A Yukl; Elena S Lysenko; Ronald J Bosch; Jun Lai; Stanley Chioma; Fatemeh Emad; et al. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS pathogens 2013;9(2):e1003174.

Expertise

Education

  • Johns Hopkins University School of Medicine, Ph.D., 1985
  • University of New Hampshire, B.A., 1977