Highlights
Age Groups Seen
- Infant 0-2
- Child 3-12
- Adolescent 13-17
- Young Adult 18-25
- Adult 26-64
- Older Adult 65+
Languages
- English
In-Network Plans
View All Accepted Plans (12)Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Howard M. Lederman
Professional Titles
- Director, Immunodeficiency Clinic
- Director, Ataxia-Telangiectasia Clinical Center
- Director, Pediatric Immunology Laboratory
Primary Academic Title
Professor of Pediatrics
Johns Hopkins Physician
Background
Dr. Howard Lederman is a professor of pediatrics at the Johns Hopkins University School of Medicine. He is the director of the Immunodeficiency Clinic, the Pediatric Immunology Laboratory, and the Ataxia-Telangiectasia (A-T) Clinical Center.
Dr. Lederman specializes in the evaluation, diagnostic testing and long-term management of patients of all ages who have known or suspected primary immunodeficiency diseases. He is an expert on the use of gamma globulin therapy for a wide variety of disorders.
After receiving his M.D. and Ph.D. from the University of Michigan, Dr. Lederman came to Johns Hopkins Children’s Center for a residency in pediatrics, followed by a fellowship in immunology at the Hospital for Sick Children in Toronto.
Dr. Lederman’s current research laboratory and clinical research focuses on better understanding and treating patients with ataxia-telangiectasia, a devastating neurological disorder for which there is no cure.
He is a member of numerous professional societies, including American Association of Immunologists, the American Society for Microbiology and the Clinical Immunology Society.
Centers and Institutes
CV
http://www.hopkinsmedicine.org/johns-hopkins-childrens-center/_documents/_cvs/lederman_howard_cv.pdf
Clinical Trial Keywords
Immunoglobulin; Gamma globulin; Ataxia- Telangiectasia
Clinical Trials Summary
Cell-Based Approaches For Modeling and Treating Ataxia-Telangiectasia
Find a Clinical Trial
View all trials by this principal investigator.
Additional Academic Titles
Joint Appointment in Medicine
Research Interests
Antibody deficiency, Ataxia-Telangiectasia, Chronic granulomatous disease and other disorders of phagocytes, Common variable immunodeficiency, Complement deficiency, DiGeorge syndrome, Hyper-IgE syndrome, Hyper-IgM syndrome, Hypogammaglobulinemia, IgA deficiency, IgM deficiency, Immunoglobulin therapy, IVIG, Primary Immunodeficiency Diseases, Severe combined immunodeficiency, Wiskott-Aldrich syndrome, X-linked agammaglobulinemia
Research Summary
Dr. Lederman’s current research laboratory and clinical research focuses on better understanding and treating patients with ataxia-telangiectasia, a devastating neurological disorder for which there is no cure.
Selected Publications
Alterman N, Fattal-Valevski A, Moyal L, Crawford TO, Lederman HM, Ziv Y, and Shiloh Y. “Ataxia-Telangiectasia: Mild neurological presentation despite null ATM mutation and severe cellular phenotype.” Am J Med Genet A. 2007 Aug 15;143A(16):1827-34.
Daniels JA, Maitra A, Lederman HM, and Montgomery E. “Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): A clinicopathologic study and review.” Am J Surg Pathol. 2007 Dec;31(12):1800-12.
Lin, DDM, Crawford TO, Lederman HM, Barker PB. “Proton MR Spectroscopic Imaging in Ataxia-Telangiectasia.” Neuropediatrics. 2006 Aug;37(4):241-6.
McGrath-Morrow S, Lefton-Greif M, Rosquist K, Crawford T, Kelly A, Zeitlin P, Carson K , Lederman HM. “Pulmonary function in adolescents with ataxia-telangiectasia.” Pediatr Pulmonol. 2008 Jan;43(1):59-66.
Shreffler WG, Visness CM, Burger M, Cruikshank WW, Lederman HM, de la Morena M, Grindle K, Calatroni A, Sampson HA and Gern JE. “Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study.” BMC Immunol. 2006 Dec 12;7:29.
Memberships
- American Association of Immunologists
- American Society for Microbiology
- Clinical Immunology Society
- Infectious Diseases Society of America
- Society for Pediatric Research
Locations
- Rubenstein Child Health Building
- 200 North Wolfe Street, Rubenstein BLDG Lower Level, Baltimore, MD 21287
- Get Directions
- phone: 443-997-5437
- fax: 410-955-0229
Expertise
Education
- Fellowship: University of Toronto Health, Immunology, 1983
- Residency: Johns Hopkins University School of Medicine, Pediatrics, 1981
- Graduate School: University of Michigan, Immunology, PhD, 1978
- Medical Education: University of Michigan Medical School, MD, 1977
Board Certifications
- Pediatrics: American Board of Pediatrics, 1984
Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
4.9 out of 5
77 ratings, 28 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 5 out of 5 starsReviewed on 3/9/2026
Dr Lederman is a wonderful Dr and person. He carefully reviews my health situation and listens to what I say. He had some great recommendations for me to follow up with to help improve my quality of life. So informative.
- 5 out of 5 starsReviewed on 2/25/2026
Very good communicators both the doctor and his PA.
- 5 out of 5 starsReviewed on 2/18/2026
Dr. Lederman is an excellent physician, whom I have total confidence that I am getting the best care I can get, for what I see him for.
- 5 out of 5 starsReviewed on 2/4/2026
Dr. Lederman is the best doctor I have ever known.
- 5 out of 5 starsReviewed on 2/2/2026
The provider and his assistant were very patient, thorough, and took copious notes. I never felt rushed while I explained my issues.
- 5 out of 5 starsReviewed on 12/8/2025
Great!
- 5 out of 5 starsReviewed on 11/12/2025
Dr. Lederman is the best. I see him once a year and he is always going beyond to make sure I stay well.
- 5 out of 5 starsReviewed on 11/3/2025
Fantastic, the best
- 5 out of 5 starsReviewed on 11/3/2025
They are simply the best
- 5 out of 5 starsReviewed on 10/29/2025
Excellent Doctor who obviously knows Immunology.
- 5 out of 5 starsReviewed on 10/13/2025
He spent a lot of time listening to my concerns and offered helpful suggestions.
- 5 out of 5 starsReviewed on 10/13/2025
Very detailed questions, showed great interest in how I was doing, asked several follow up questions which led to a very comprehensive medical visit. I had forgotten to mention a few issues (I have many) and their questions and noticing a few things (swollen knuckles) plus follow up questions led to a very detailed and helpful visit. I also asked a question the evening after I was seen and received a prompt reply the following morning.
- 5 out of 5 starsReviewed on 9/26/2025
The provider is kind, friendly and very attuned to me personally.
- 5 out of 5 starsReviewed on 9/17/2025
Dr. Lederman and [staff] are absolutely the best possible providers. I am so fortunate to be their patient!!
- 5 out of 5 starsReviewed on 9/17/2025
Dr Lederman and [staff] are the main reasons I return to Johns Hopkins. Dr
- 5 out of 5 starsReviewed on 8/20/2025
Excellent and very friendly, I felt Very comfotable
- 5 out of 5 starsReviewed on 8/13/2025
Dr Lederman and [staff] closely monitor their patients. Both have been very supportive of me. For example, when my pump broke breaking my medication they Contacted the pharmacy and ordered new medication, pump and supplies and called me with instructions on how and what to do. This was on a Saturday.
- 5 out of 5 starsReviewed on 7/30/2025
The best
- 5 out of 5 starsReviewed on 7/28/2025
My provider took an interest in more than just my immune system. In sharing my medical history with my doctor since the last year's visit, my doctor asked questions and showed interest in helping me with other health problems.
- 5 out of 5 starsReviewed on 7/23/2025
He was wonderful with our 20 month old son. He listened to our concerns and was thorough with his assessment and was able to make our son feel comfortable and helped him cooperate. Working with children is definitely his calling
- 5 out of 5 starsReviewed on 7/23/2025
Dr. Lederman is great. I feel very well taken care of.
- 5 out of 5 starsReviewed on 7/16/2025
I am so grateful to be a patient of Dr. Lederman. He is a brilliant physician , a kind and caring man and he thinks out of the box.
- 5 out of 5 starsReviewed on 7/7/2025
I certainly understand that patient care can be complicated, and that the doctor had a complicated case to handle before mine, but the doctor was over one hour late for my appointment. I was not informed of this delay for over 30 minutes.
- 5 out of 5 starsReviewed on 6/30/2025
Very concerned about my treatment and getting information to the doctors back home to make sure everything was done correctly
- 5 out of 5 starsReviewed on 6/18/2025
Dr. Lederman is expert and takes time to explain everything completely.
- 5 out of 5 starsReviewed on 6/13/2025
Excellent professional
- 5 out of 5 starsReviewed on 5/19/2025
My provider and his team are outstanding, knowledgeable and caring.
- 5 out of 5 starsReviewed on 5/7/2025
We fly from Florida for this annual appointment with Dr. Lederman, and have done so since he diagnosed my CVID in 2011.