Debasish Sinha, MS, PhD

Primary Academic Title

Professor of Ophthalmology

Research Interests

Lysosome Biology, Autophagy, Cell Signaling

Lab Website

Debasish Sinha Laboratory

Research Summary

Dr. Sinha’s research is focused on unique protein(s) that regulate the assembly of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway in RPE cells. One of our research priorities is to identify upstream and downstream targets to modulate mTORC1 activity. In theory, this would allow us to regain control over or otherwise regulate autophagy in the lysosome of the RPE and is a novel approach to rejuvenate lysosomal function of the RPE to develop therapeutic target in age-related macular degeneration (AMD).

Graduate Program Affiliations

Pathobiology

Visual Neuroscience Training Program