Danny Muehlschlegel, MD, MBA, MSc
Anesthesiology
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Danny Muehlschlegel
Professional Titles
- Chair, Department of Anesthesiology and Critical Care Medicine
- Mark C. Rogers Chair in Anesthesiology and Critical Care Medicine
Primary Academic Title
Professor of Anesthesiology and Critical Care Medicine
Johns Hopkins Physician
Background
Dr. Danny Muehlschlegel is the Mark C. Rogers Professor and Chair of the Department of Anesthesiology and Critical Care Medicine at the Johns Hopkins University School of Medicine, where he leads a multi-site perioperative enterprise spanning The Johns Hopkins Hospital, Bayview, Howard County, and affiliated sites. He is a practicing cardiovascular anesthesiologist with subspecialty expertise in transesophageal echocardiography and the perioperative care of patients with complex cardiovascular disease.
As an NIH-funded physician-scientist, Dr. Muehlschlegel directs a translational research program centered on perioperative genomics and multi-omics in cardiac surgery. His group integrates genome-wide association data, polygenic risk scores, transcriptomics, and emerging digital biomarkers to predict and prevent adverse cardiovascular events after surgery, with postoperative atrial fibrillation as a central clinical anchor. He founded and leads the NHLBI-sponsored TRANSCRIBE and GENEXPRO Surg studies, which together define the genetic and transcriptomic architecture of perioperative myocardial injury and atrial fibrillation.
Beyond Hopkins, Dr. Muehlschlegel is the Vice Chair of the American Heart Association’s Council on Cardiovascular Surgery and Anesthesia. He is a member of the Association of University Anesthesiologists and the Association of Cardiac Anesthesiologists, and an associate oral board examiner for the American Board of Anesthesiology, roles through which he helps shape national standards in academic anesthesiology.
X Profile
Research Summary
My research investigates the impact of genetic variation on adverse cardiovascular events and their functional significance. My cardiac anesthesia patients, possessing transcriptional upregulation, serve as research subjects, enabling genetic transcription variation analysis. I spearhead the CABG Genomics and TRANSCRIBE study groups, focusing on genetic variation's role in perioperative myocardial injury during cardiac surgery. I also manage the GENEXPRO Surg project, utilizing multi 'omics approaches to understand postoperative atrial fibrillation. As Chief Scientific Officer for Team Heart, I blend clinical cardiac anesthesia with genetic research, examining the genetics behind rheumatic heart disease in Rwanda through the RECHARGE study.
Google Scholar - Publications
PubMed - Publications
Selected Publications
Kelly BJ, Ho Luxford JM, Butler CG, Huang CC, Wilusz K, Ejiofor JI, Rawn JD, Fox JA, Shernan SK, Muehlschlegel JD. Severity of tricuspid regurgitation is associated with long-term mortality. J Thorac Cardiovasc Surg. 2018 Mar;155(3):1032-11038.e2. PMID: 29246545, PMCID: PMC5819734
Saddic LA, Nicoloro SM, Gupta OT, Czech MP, Gorham J, Shernan SK, Seidman CE, Seidman JG, Aranki SF, Body SC, Fitzgibbons TP, Muehlschlegel JD. Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia. Cardiovasc Diabetol. 2017 Jul 7;16(1):87. PMID: 28687077, PMCID
Stone G, Choi A, Meritxell O, Gorham J, Heydarpour M, Seidman CE, Seidman JG, Aranki SF, Body SC, Carey VJ, Raby BA, Stranger BE, Muehlschlegel JD. Sex differences in gene expression in response to ischemia in the human left ventricular myocardium. Hum Mol Genet. 2019 May 15;28(10):1682-1693. PMID: 30649309, PMCID: PMC6494791
Ward Z, Schmeier S, Saddic L, Sigurdsson MI, Cameron VA, Pearson J, Miller A, Morley-Bunker A, Gorham J, Seidman JG, Moravec CS, Sweet WE, Aranki SF, Body S, Muehlschlegel JD*, Pilbrow AP*. Novel and Annotated Long Noncoding RNAs Associated with Ischemia in the Human Heart. Int J Mol Sci. 2021 Oct 20;22(21). PMID: 34768754, PMCID: PMC8583240. Joint senior author.
Wollborn J, Karamnov S, Fields KG, Yeh T, Muehlschlegel JD. COVID-19 increases the risk for the onset of atrial fibrillation in hospitalized patients. Sci Rep. 2022 Jul 14;12(1):12014. PMID: 35835807, PMCID: PMC9281233
Honors
- Excellence in Mentoring Award, Women in Cardiothoracic Anesthesia, 1/1/23
- Kaplan Leadership Development Award, Society of Cardiovascular Anesthesiologists, 1/1/19
- Distinguished Chair in Anesthesiology, Brigham and Women's Hospital, 1/1/18
- Distinction in Mentoring Award, Department of Anesthesiology, Perioperative and Pain Medicine, 1/1/17
Locations
- The Johns Hopkins Hospital
- 1800 Orleans Street, Baltimore, MD 21287
- Get Directions
- phone: 410-955-5000
- fax: 410-955-5001
Expertise
Education
- Graduate School: Massachusetts Institute of Technology, MBA, 2021
- Graduate School: Harvard Medical School, MMSc, 2010
- Fellowship: Brigham and Women's Hospital, Cardiac Anesthesiology, 2008
- Residency: University of Florida Shands Hospital, Anesthesiology, 2006
- Medical Education: Albert-Ludwigs University Faculty of Medicine, MD, 2001
Board Certifications
- Adult Cardiac Anesthesiology: American Board of Anesthesiology, 2023
- Anesthesiology: American Board of Anesthesiology, 2007
- Advanced Perioperative Transesophageal Echocardiography: National Board of Echocardiography, 2007
Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- Veteran Affairs Community Care Network (Optum-VACCN)