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Dan Hanley Jr.

Dan Hanley Jr., MD

Neurology

Highlights

Languages

  • French
  • German
  • English

In-Network Plans

View All Accepted Plans (12)

Gender

Male

Johns Hopkins Affiliations:

  • Johns Hopkins School of Medicine Faculty

About Dan Hanley Jr.

Professional Titles

  • Division Director, BIOS Clinical Trials Coordinating Center 
  • Director, Johns Hopkins Trial Innovation Center, Trial Innovation Network, National Center for Advancing Translational Sciences
  • Deputy Director for Support and Innovation in Multicenter Trials at the Johns Hopkins Institute for Clinical and Translational Research 
  • Jeffrey and Harriet Legum Professor of Acute Care Neurology

Primary Academic Title

Professor of Neurology

Johns Hopkins Physician

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Background

Since 1996, Dr. Daniel F. Hanley has been a professor of neurology, neurosurgery, anesthesiology/critical care medicine, and nursing at Johns Hopkins University School of Medicine. Dr. Hanley founded and directed the Johns Hopkins Neurocritical Care Unit, one of the first critical care units dedicated solely to neurosurgical and neurological patients. Subsequently, in 1999, he founded and continues to direct the BIOS Clinical Trials Coordinating Center (BIOS CTCC). An academic contract research organization based at Johns Hopkins, BIOS CTCC has organized and completed more than 20 large clinical trials under his direction. He has received over 70 clinical and basic research grants, predominantly from the National Institutes of Health and the FDA Orphan Products Grants Program.

Dr. Hanley’s 40-year career in medicine has focused on clinical trial design, the organization and interpretation of drug and device trials, the development of strategic research plans, and FDA regulatory compliance. He has led international, NIH-sponsored trials including the MISTIE III and CLEAR III trials investigating minimally invasive neurosurgical techniques to treat hemorrhagic stroke. As principal investigator for the National Center for Advancing Translational Sciences (NCATS) Johns Hopkins Trial Innovation Center, Dr. Hanley leads collaborative efforts to advance education and therapeutics through innovative CTSA clinical trials.  

Currently, Dr. Hanley is the PI or multi-PI for several ongoing trials. These include a multisite phase 2/3 randomized controlled dementia prevention trial (MAP), a large multicenter clinical trial involving automated monitoring of atrial fibrillation (REACT AF), and a first-in-patient phase 2a biomarker and edema attenuation in intracerebral hemorrhage trial (BEACH).  

Dr. Hanley has published over 400 peer-reviewed articles and book chapters, received the Humboldt Research Prize for accomplishments in brain injury research, and mentored nearly 100 researchers. His trainees, which include a large number of trialists, have led 25 brain intensive care units, and over 40 have been named full professors, program leaders, or department chairs. He has served on public boards including the American Academy of Neurology, National Stroke Association, and NIH National Institute of Nursing Research.

Find a Clinical Trial

View all trials by this principal investigator.

Recent News Articles and Media Coverage

  • Could a clot-busting drug help treat a 'bleeding' stroke?, HealthDay News (Feb. 18, 2016) 

Additional Academic Titles

Professor of Anesthesiology and Critical Care Medicine, Professor of Neurological Surgery

Contact for Research Inquiries

BIOS CTCC

750 E. Pratt St.
16th Floor
Baltimore, MD 21202

PubMed - Publications

Selected Publications

  1. Hanley DF, Thompson RE, Rosenblum M, Yenokyan G, Lane K, McBee N, Mayo SW, Bistran-Hall AJ, Gandhi D, Mould WA, Ullman N, Ali H, Carhuapoma JR, Kase CS, Lees KR, Dawson J, Wilson A, Betz JF, Sugar EA, Hao Y, Avadhani R, Caron JL, Harrigan MR, Carlson AP, Bulters D, LeDoux D, Huang J, Cobb C, Gupta G, Kitagawa R, Chicoine MR, Patel H, Dodd R, Camarata PJ, Wolfe S, Stadnik A, Money PL, Mitchell P, Sarabia R, Harnof S, Barzo P, Unterberg A, Teitelbaum JS, Wang W, Anderson CS, Mendelow AD, Gregson B, Janis S, Vespa P, Ziai W, Zuccarello M, Awad IA; MISTIE III Investigators. Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial. Lancet. 2019 Mar 9;393(10175):1021-1032. doi: 10.1016/S0140-6736(19)30195-3. Epub 2019 Feb 7. Erratum in: Lancet. 2019 Apr 20;393(10181):1596. doi: 10.1016/S0140-6736(19)30859-1. PMID: 30739747; PMCID: PMC6894906.
  2. Hanley DF, Lane K, McBee N, Ziai W, Tuhrim S, Lees KR, Dawson J, Gandhi D, Ullman N, Mould WA, Mayo SW, Mendelow AD, Gregson B, Butcher K, Vespa P, Wright DW, Kase CS, Carhuapoma JR, Keyl PM, Diener-West M, Muschelli J, Betz JF, Thompson CB, Sugar EA, Yenokyan G, Janis S, John S, Harnof S, Lopez GA, Aldrich EF, Harrigan MR, Ansari S, Jallo J, Caron JL, LeDoux D, Adeoye O, Zuccarello M, Adams HP Jr, Rosenblum M, Thompson RE, Awad IA; CLEAR III Investigators. Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial. Lancet. 2017 Feb 11;389(10069):603-611. doi: 10.1016/S0140-6736(16)32410-2. Epub 2017 Jan 10. PMID: 28081952; PMCID: PMC6108339.
  3. Luciano MG, Williams MA, Hamilton MG, Katzen HL, Dasher NA, Moghekar A, Hua J, Malm J, Eklund A, Alpert Abel N, Raslan AM, Elder BD, Savage JJ, Barrow DL, Shahlaie K, Jensen H, Zwimpfer TJ, Wollett J, Hanley DF, Holubkov R; PENS Trial Investigators and the Adult Hydrocephalus Clinical Research Network. A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus. N Engl J Med. 2025 Dec 4;393(22):2198-2209. doi: 10.1056/NEJMoa2503109. Epub 2025 Sep 16. PMID: 40960253; PMCID: PMC12682072.
  4. Awad IA, Alcazar-Felix RJ, Stadnik A, Kinkade S, Jhaveri A, Lee J, Hage S, Iqbal J, Polster SP, Shenkar R, Treine K, McBee N, Ostapkovich N, Lane K, Liao JK, Sorrentino M, Lee C, Flemming KD, Girard R, Carroll TJ, Thompson RE, Hanley DF. Safety and efficacy of atorvastatin for rebleeding in cerebral cavernous malformations (AT CASH EPOC): a phase 1/2a, randomised placebo-controlled trial. Lancet Neurol. 2025 Apr;24(4):295-304. doi: 10.1016/S1474-4422(25)00036-5. PMID: 40120614; PMCID: PMC12080613.
  5. Ziai WC, McBee N, Lane K, Lees KR, Dawson J, Vespa P, Thompson RE, Mendelow AD, Kase CS, Carhuapoma JR, Thompson CB, Mayo SW, Reilly P, Janis S, Anderson CS, Harrigan MR, Camarata PJ, Caron JL, Zuccarello M, Awad IA, Hanley DF; MISTIE III Investigators. A randomized 500-subject open-label phase 3 clinical trial of minimally invasive surgery plus alteplase in intracerebral hemorrhage evacuation (MISTIE III). Int J Stroke. 2019 Jul;14(5):548-554. doi: 10.1177/1747493019839280. Epub 2019 Apr 3. PMID: 30943878; PMCID: PMC6706298.

Honors

  • Top 10 Clinical Research Achievement Awardee: Early COVID-19 Treatment with COVID-19 Convalescent Plasma, 2023 

  • Distinguished Investigator Award, Society of Critical Care Medicine, 2018 

  • Hans Chiari Memorial Lecture Award, Austrian Stroke Research Society, 2016 

  • Merril Spencer Award, Swedish Hospital, Seattle, WA, 2007 

  • Doctorate Honoris Causa, Ivane Javakhishvili Tbilisi State University, 2006 

  • Honorary Professor of Neurology, Georgian State Medical Academy, 2003 

  • Visionary in Practice Award, National Stroke Association, 2000 

  • Jeffrey and Harriet Legum Endowed Chair in Acute Care Neurology, Johns Hopkins University School of Medicine, 1999 

  • President's Citation Award, Society of Critical Care Medicine, 1997 

  • Alexander Humboldt Research Prize, Alexander von Humboldt Foundation, 1996 

Memberships

  • American Medical Association 

    • Member since 1980 

  • American Academy of Neurology

    • Member since 1980; fellow status since 1995 

  • American Physiologic Society

    • Honorific member 

  • National Stroke Association

    • Member since 1998 

  • American Physiological Society

    • ​​​​​​​Member since 1989 

  • Society of Critical Care Medicine

    • ​​​​​​​Member since 1991 

  • American Neurological Association

    • Elected member since 1991 

  • Society of Critical Care Medicine 

  • American Heart Association/American Stroke Association

    • Stroke Council Fellow since 2001 

  • World Federation of Neurology

    • ​​​​​​​Member since 1991 

  • European Stroke Organisation/World Stroke Organisation 

    • Member since 2016 

  • German Society for Neurocritical Care and Emergency Medicine (ANIM)

    • ​​​​​​​Member since 1996

Locations

  1. The Johns Hopkins Hospital

Expertise

Education

  • Fellowship: Johns Hopkins University School of Medicine, Neurology, 1983
  • Residency: Johns Hopkins University School of Medicine, Neurology, 1981
  • Medical Education: Weill Cornell Medical College, MD, 1975

Board Certifications

  • Neurology: American Board of Psychiatry and Neurology, 1990
  • Internal Medicine: American Board of Internal Medicine, 1978

Insurance

Search plans
  • Aetna
  • CareFirst
  • Cigna
  • First Health
  • Geisinger Health Plan
  • HealthSmart/Accel
  • Johns Hopkins Health Plans
  • MultiPlan
  • Pennsylvania's Preferred Health Networks (PPHN)
  • Point Comfort Underwriters
  • Private Healthcare Systems (PHCS)
  • Veteran Affairs Community Care Network (Optum-VACCN)