Constance L. Monitto, MD
Pediatric Pain MedicinePediatric Anesthesiology
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Constance L. Monitto
Primary Academic Title
Associate Professor of Anesthesiology and Critical Care Medicine
Johns Hopkins Physician
Background
Dr. Constance L. Monitto is an assistant professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. Her clinical work focuses on intraoperative anesthetic management of pediatric patients as well as attending on the pediatric acute pain service.
She serves as associate clinical director of pediatric anesthesiology at the Johns Hopkins University School of Medicine.
Dr. Monitto received her undergraduate degree in physics from Princeton University and earned her medical degree from Harvard Medical School. She completed a residency in pediatrics at The Children’s Hospital, Boston, and a residency in anesthesia at Massachusetts General Hospital. She also completed a subspecialty residency in pediatric anesthesia at The Children’s Hospital of Philadelphia (CHOP). After remaining on staff at CHOP for two years, Dr. Monitto joined the Johns Hopkins faculty in 1994.
Dr. Monitto's clinical research interest is pediatric pain management and her basic science research involves assessing the impact of epigenetic gene regulation on the development of resistance to chemotherapeutic agents in cancer.
She is a member of the American Academy of Pediatrics, the American Society of Anesthesiologists, the Society for Pediatric Anesthesia and the International Anesthesia Research Society.
Centers and Institutes
Recent News Articles and Media Coverage
Research Interests
Assessing the impact of epigenetic gene regulation on the development of resistance to chemotherapeutic agents in cancer, Pediatric pain management
Lab Website
Constance Monitto Lab - Lab Website
Research Summary
Dr. Constance L. Monitto is involved in both clinical and basic science research. Her clinical research is focused on pediatric pain management. She and her coworkers are assessing the impact of low-dose opioid antagonism on opioid-related side effects, such as nausea, vomiting, and pruritis. They also are completing analysis of data regarding current methods of pediatric pain management across the country.
In her basic science studies, Dr. Monitto is assessing the impact of epigenetic gene regulation on the development of resistance to chemotherapeutic agents in cancer. She is identifying genes that are silenced or downregulated in drug-resistant cell lines and comparing those to their drug-sensitive, isogeneic counterparts by microarray assessment of gene expression followed by pharmacologic unmasking of methylated genes using the compound 5-deoxyazacytidine. Candidate genes are further assessed by siRNA gene silencing. Her clinical research involves pediatric pain management.
Selected Publications
- Singh D, Gross RM, Monitto C, Heitmiller E, Njoku D. “In-depth analysis of a subset of POCA registrants: impact on strategies for successful resuscitation.” Anesthesiology. 2007; 107:A1934.
- Nelson KL, Yaster M, Kost-Byerly S, Monitto C. “Patient controlled analgesia by proxy: results from a national survey.” Anesthesiology. 2007;107:A685.
- Nelson KL, Yaster M, Kost-Byerly S, Monitto C. “Pediatric pain management – results of a national survey of pediatric anesthesiologists.” Anesthesiology. 2007;107:A688.
- Hoque MO, Soria JC, Woo J, Lee T, Lee J, Jang SJ, Udaphyay S, Trink B, Monitto C, Desmaze C, Mao L. Sidransky D, Moon C. “Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth.” Am J Pathol. 2006;168(4):1345-1353. doi: 10.2353/ajpath.2006.050596.
- Xiao Y, Monitto CL, Minhas KM, Sidransky D. “Lactoferrin down-regulates G1 cyclin-dependent kinases during growth arrest of head and neck cancer cells.” Clin Canc Res. 2004;10(24):8683-8686. doi: 10.1158/1078-0432.CCR-04-098.
Honors
Research Day Award, Department of Anesthesiology and Critical Care Medicine, 1/1/09
Memberships
- American Academy of Pediatrics
- American Society of Anesthesiologists
- International Anesthesia Research Society
- Society for Pediatric Anesthesia
Professional Activities
- Anesthesia and Analgesia, Guest Reviewer
- British Journal of Cancer, Guest Reviewer
- Clinical Cancer Research, Guest Reviewer
Locations
- The Johns Hopkins Hospital
- 1800 Orleans Street, Baltimore, MD 21287
- Get Directions
- phone: 410-955-5000
- fax: 410-955-5001
Expertise
Education
- Fellowship: Children's Hospital of Philadelphia, Anesthesiology and Critical Care Medicine, 1991
- Residency: Massachusetts General Hospital, Anesthesiology, 1990
- Residency: Boston Children's Hospital, Pediatrics, 1988
- Medical Education: Harvard Medical School, Medicine, MD, 1985
Board Certifications
- Pediatric Anesthesiology: American Board of Anesthesiology, 2014
- Anesthesiology: American Board of Anesthesiology, 1992
Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- Veteran Affairs Community Care Network (Optum-VACCN)