Clifton Bingham III, MD

Professional Titles

• Director, Johns Hopkins Arthritis Center
• Director, Center for Patient Centered Outcomes Research in Rheumatology
• Deputy Director for Research, Division of Rheumatology
• Co-Director, Rheumatic Diseases Research Core Center

Primary Academic Title

Professor of Medicine

Background

Centers and Institutes

• Arthritis Center
• Patient Centered Outcomes Research in Rheumatology, Center for

Clinical Trial Keywords

Rheumatoid arthritis, clinical trials, outcome measures, patient-reported outcomes, psoriatic arthritis, spondyloarthritis, patient centered outcomes research

Clinical Trials Summary

http://www.hopkinsarthritis.org/arthritis-research/

http://www.hopkinsarthritis.org/arthritis-research/patient-centered-outcomes-research/understanding-patient-centered-outcomes-research/

http://www.hopkinsarthritis.org/arthritis-research/clinical-trials/

Find a Clinical Trial

Contact for Research Inquiries

5200 Eastern Avenue
Mason F. Lord, Center Tower, Room 404
Baltimore, MD 21224

Phone: (410) 550-0578

Research Interests

Arthritis Therapeutics, Clinic Trial outcomes in Arthritis, Patient Reported Outcomes, Rheumatoid Arthritis

Lab Website

Clifton O. Bingham III Lab

• Research in the Clifton O. Bingham III Lab focuses on defining clinical and biochemical disease phenotypes related to therapeutic responses in rheumatoid arthritis and osteoarthritis; developing rational clinical trial designs to test new treatments; improving patient-reported outcome measures; evaluating novel imaging modalities for arthritis; and examining the role of oral health in inflammatory arthritis.

Research Summary

Dr. Bingham’s current research is broadly centered on improving the assessment of patients with inflammatory arthritis through more precise disease phenotyping, spanning from biochemical characterization to measuring individual patient level disease experience and contextual factors.  This work takes advantage of an integrated clinical and research operation and infrastructure to couple investigation with clinical care.

Dr. Bingham directs a number of research projects: (1) Improving the assessment of the patient’s perspective of inflammatory arthritis through development and testing of patient reported outcome measures (e.g. PROMIS); (2) Developing and improving methods to evaluate novel immunomodulatory therapies and treatment strategies; and (3) Identifying patient subsets in inflammatory arthritis utilizing the Johns Hopkins Precision Medicine Analytical Platform (PMAP);.  Additional ongoing collaborative projects are evaluating advanced technologies and molecular diagnostics for imaging RA and OA, mechanisms and mediators of pain in arthritis, and novel bioengineered compounds and stem cells to reduce inflammation and potentially promote joint repair.

Google Scholar - Publications

http://scholar.google.com/citations?view_op=list_works&hl=en&user=i4scvdMAAAAJ&gmla=AJsN-F5CuMJkJ1wY2vAj_5ZrWm43woseT76clyPHrwXGhIycPkOpZVeegs0rSYsOHCEwQuVC8e5xvJ7E4rr-YtK6PsxtIV8qEbQUQ1JtlhBcnZEgRbsjwBg

PubMed - Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=bingham+co

Selected Publications

• Bartlett SJ, Bykerk VB, Cooksey R, Choy EH, Alten R, Christensen R, Furst DR, Guillemin F, Halls S,  Hewlett S, Leong AL, Lyddiatt A, March L, Monte P, Orbai AM, Pohl C, Voshaar MS, Woodworth TG, Bingham CO 3rd. Feasibility and domain validation of RA flare core domain set: A report of the OMERACT Flare working group. J Rheumatol 2015 Feb 15. pii: jrheum.141169. [Epub 2015 Feb 15] PMID: 25684764. 

   

• Bartlett SJ, Haaz S, Mill C, Bernatsky S, Bingham CO 3rd. Yoga in rheumatic diseases.  Curr Rheumatol Rep 2013 Dec;15(12):387. (Invited Review). PMID: 24173693. 

• Bingham CO 3rd, Alten R, DeWit MP.  The Importance of Patient Participation in Measuring Rheumatoid Arthritis Flares.  Ann Rheum Dis, 2012;71:7 1107-1109. (Invited Editorial). PMID: 22323439.

• Bingham CO 3rd, Rizzo W, Kivitz A, Hassanali A, Upmanyu R, Klearman M. Humoral immune response to vaccines in rheumatoid arthritis patients treated with tocilizumab: results of a randomized controlled trial (VISARA). Ann Rheum Dis 2015; 74:818-822.[Epub 21 Jan 2014]. PMID: 2448345.

• Boers M, Kirwan JR, Wells G, Beaton D, Gossec L, D’Agostino MA, Conaghan PG, Bingham CO 3rd, Brooks PB, Landewe R, March L, Simon LS, Singh JA, Strand V, Tugwell PT. Developing core outcome measurement sets for clinical trials: OMERACT Filter 2.0. J Clin Epi 2014 Jul;67(7):745-53. PMID: 24582946 

• McMahan ZH, Bingham CO 3rd. Effects of biological and nonbiological immunomodulatory therapies on the immunogenicity of vaccines in patients with rheumatic diseases.  Arthritis Res Ther 2014; 16:506  doi:10.1186/s13075-014-0506-0. PMID: 25587634.

• Moonaz SH, Bingham CO 3rd, Wissow L, Bartlett SJ.  Yoga in Sedentary Adults with Arthritis: Effects of a Randomized Controlled Pragmatic Trial. J Rheumatol Jul;42(7):1194-202. doi: 10.3899/jrheum.141129. Epub 2015 Apr 1. PMID: 25834206.

• Orbai AM, Bingham CO 3rd. Patient-reported outcomes in rheumatoid arthritis.  Curr Rheumatol Rep. 2015 Apr;17(4):501. doi: 10.1007/s11926-015-0501-8. (Invited Review).PMID: 25854489.

• Orbai AM, Smith KC, Bartlett SJ, DeLeon E, Bingham CO 3rd. “Stiffness has different meanings, I think, to everyone.” Examining stiffness from the perspective of people living with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014 Nov; 66(11):1662-72. PMID: 24891304. 

• Timlin H, Bingham CO 3rd.  Efficacy and safety implications of molecular constructs of biological agents for rheumatoid arthritis.  Expert Opin Biol Ther 2014;14(7):893-904. (Invited Review). PMID: 24720727.

• Winthrop KL, Silverfield J, Racewicz A, Neal J, Lee EB, Hrycaj P, Gomez-Reino J, Soma K, Riese R, Mebus C, Wilkinson B, Hodge J, Fan H, Wang T, Bingham CO 3rd.  The effect of tofacitinib on pneumococcal and influenza vaccine responses in rheumatoid arthritis.  Ann Rheum Dis 2015 March 20, doi:10.1136/ annrheumdis-2014-207191 [Epub 2015 March 20]. PMID: 5795907.

Courses & Syllabi

• Advances in the Diagnosis and Treatment of the Rheumatic Diseases, Johns Hopkins University
• Advancing Patient Centered Outcomes Research, Johns Hopkins University

Honors

Diplomate, American Board of Rheumatology

Lectures & Presentations

• Engaging Stakeholder Input in a Study of Patient-Reported Outcomes in Arthritis Clinical Care, Lecture, Fostering and Assessing Patient and Stakeholder Engagement in PCORI Pilot Projects, Annual Research Meeting Panel, Academy Health, San Diego, CA, 1/1/14
• Immunizations in Rheumatic Diseases, Lecture, Biological Therapies Summit, Cleveland Clinic, Clevland, OH, 1/1/15
• Patient Centered Outcomes Research: IRB Centered Challenges: The Investigator's Perspective, Panel, Advancing Ethical Research Conference Panel, Public Responsibility in Medicine and Research, Baltimore, MD, 1/1/14
• Rheumatoid Arthritis and Immunobiological Therapy, Lecture, Multidisciplinary Educational Symposium, Porto Allegre, Brasi, 1/1/15
• Using PROMIS in PCOR: Lessons from PCORI's Pilot Projects, Lecture, Advances in Patient-Centered Outcomes Research, Inaugural Conference, PROMIS Health Organization, Philadelphia, PA, 1/1/15
• Using PROMIS Measures in RA Clinical Care, Lecture, Inaugural Meeting, Canadian Patient Reported Outcomes Network, Montreal, Canada, 1/1/13
• Using PROs in Rheumatology Clinical Care, Lecture, Annual Meeting, American College of Rheumatology, Boston, MA, 1/1/14

Memberships

• American Academy of Allergy, Asthma, and Immunology, Fellow
• American College of Rheumatology, Fellow
• Outcome Measures in Rheumatology (OMERACT),

  Executive Committee Member

Professional Activities

• Annals of Rheumatic Diseases, Journal Reviewer
• Arthritis and Rheumatism/Arthritis and Rheumatology, Journal Reviewer
• Arthritis and Rheumatology (formerly Arthritis and Rheumatism), Co-Editor
• Arthritis Care and Research, Journal Reviewer
• Arthritis Research and Therapy, Journal Reviewer
• Clinical Care in the Rheumatic Diseases, Third Edition, 2006, Association of Rheumatology Health Professionals, Associate Editor, 1/1/06 - 12/31/06
• Johns Hopkins Bayview Medical Center, Bayview Scientific Advisory Board, 1/1/07
• Johns Hopkins Bayview Medical Center, Center for Innovative Medicine Member, 1/1/13
• Johns Hopkins Medicine, Leadership Development Program, 1/1/11 - 12/31/11
• Johns Hopkins School of Medicine, Taskforce for the Systematic Collection of Patient Reported Outcomes, 1/1/13
• Journal of Clinical Rheumatology, Journal Reviewer
• Journal of Rheumatology, Journal Reviewer
• Nature Reviews in Rheumatology, Journal Reviewer
• Osteoarthritis and Cartilage, Journal Reviewer
• Rheumatology (Oxford), Journal Reviewer
• Scandinavian Journal of Rheumatology, Journal Reviewer
• Seminars in Arthritis and Rheumatism, Journal Reviewer