Loading Complete
Christine Hann

Christine Hann, MD, PhD

Medical Oncology

Accepting New Patients

Highlights

Age Groups Seen

  • Young Adult 18-25
  • Adult 26-64
  • Older Adult 65+

Languages

  • English

Gender

Female

Johns Hopkins Affiliations:

  • Johns Hopkins School of Medicine Faculty

About Christine Hann

Primary Academic Title

Associate Professor of Oncology

Johns Hopkins Physician

Logo for Johns Hopkins Physician

Background

Christine L Hann, completed her MD and Ph.D. at Jefferson Medical College/Thomas Jefferson University  follwed by an internal medicine residency at the University of Chicago Hospitals. Following a fellowship at Johns Hopkins University in Hematology and Oncology, Dr. Hann joined the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center as a member of the Upper Aerodigestive Cancer Program and sees patients with non-small cell and small cell lung cancer.

Dr. Hann's research focus is on developing novel therapeutics for lung cancer, particularly small cell lung cancer (SCLC) and neuroendocrine tumors (NETs) such as carcinoid tumors of the lung. As a faculty member she is involved in both clinical and laboratory research.

Specific research projects include:

1) Studying mechanisms of resistant to small molecule inhibitors of the antiapoptotic protein, BCL-2 using patient-derived xenograft models. Her preclinical work has led to an NCI-sponsored Phase 1/2 clinical trial combining a BCL-2 inhibitor with a TORC1/2 inhibitors which is currently underway (NCT03366103).

2) Preclinical evaluation of various therapeutics including epigenetic modulators (LSD1 inhibitors) and nanoliposome chemotherapy in SCLC PDXs;

3) Modeling and characterizing chemoradiotherapy resistance in preclinical models of SCLC. She, along with Dr. Luigi Marchionni in Biostatistics and Dr. Phuoc Tran in the Department of Radiation Oncology, were recently awarded a 5-year NCI-sponsored U01 grant to study mechanisms of chemoradiation resistance in SCLC. 

Dr. Hann is PI of several trials in SCLC and NSCLC and is leading investigator-initiated clinical trials in SCLC and NETs.

Clinical Trial Keywords

lung cancer

Find a Clinical Trial

View all trials by this principal investigator.

Research Interests

New drug development for lung cancer, Small cell and non-small cell lung cancer

Selected Publications

  • Belani CP, Dahlberg SE, Rudin CM, Fleisher M, Chen HX, Takebe N, Velasco MR Jr, Tester WJ, Sturtz K, Hann CL, Shanks JC, Monga M, Ramalingam SS, Schiller JH. Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive-stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E1508). Cancer. 2016 May 10. doi: 10.1002/cncr.30062. [Epub ahead of print] PMID: 27163943

  • Bunn PA Jr, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR. Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes? J Thorac Oncol. 2016 Apr;11(4):453-74. doi: 10.1016/j.jtho.2016.01.012. Epub 2016 Jan 30. Review. No abstract available. PMID: 26829312

  • MacDiarmid JA, Langova V, Bailey D, Pattison ST, Pattison SL, Christensen N, Armstrong LR, Brahmbhatt VN, Smolarczyk K, Harrison MT, Costa M, Mugridge NB, Sedliarou I, Grimes NA, Kiss DL, Stillman B, Hann CL, Gallia GL, Graham RM, Brahmbhatt H. Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model. PLoS One. 2016 Apr 6;11(4):e0151832. doi: 10.1371/journal.pone.0151832. eCollection 2016. PMID: 27050167

  • Rudin CM, Ismaila N, Hann CL, Malhotra N, Movsas B, Norris K, Pietanza MC, Ramalingam SS, Turrisi AT 3rd, Giaccone G. Treatment of Small-Cell Lung Cancer: American Society of Clinical Oncology Endorsement of the American College of Chest Physicians Guideline. J Clin Oncol. 2015 Dec 1;33(34):4106-11. doi: 10.1200/JCO.2015.63.7918. Epub 2015 Sep 8. PMID: 26351333

  • Sun H, Luo L, Lal B, Ma X, Chen L, Hann CL, Fulton AM, Leahy DJ, Laterra J, Li M.  A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nat Commun. 2016 Feb 4;7:10339. doi: 10.1038/ncomms10339. PMID: 26842342 

Honors

  • Young Clinical Scientist Award, Flight Attendant Medical Research Institute, 1/1/07
  • Pearl M. Stetler Fellowship Award for Women Physicians, Johns Hopkins University, 1/1/06
  • Young Investigator Award, American Society of Clinical Oncology, 1/1/05

Memberships

  • American Association for Cancer Research
  • American Society of Clinical Oncology
  • International Association for the Study of Lung Cancer

Locations

  1. Johns Hopkins Bayview Medical Center
    • 300 Mason Lord Drive, Kimmel Cancer Center, Baltimore, MD 21224
    • Get Directions
  2. Skip Viragh Outpatient Cancer Center
    • 201 North Broadway Street, Viragh BLDG 5th FL, Baltimore, MD 21287
    • Get Directions
  3. Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville
    • 10803 Falls Road, Pavilion III STE 1500, Lutherville, MD 21093
    • Get Directions

Expertise

Education

  • Fellowship: Johns Hopkins University School of Medicine, Hematology and Oncology, 2007
  • Residency: University of Chicago Medicine, Internal Medicine, 2002
  • Medical Education: Sidney Kimmel Medical College, Biochemistry and Molecular Biology, MD PhD, 2000

Board Certifications

  • Medical Oncology: American Board of Internal Medicine, 2006

Insurance

Search plans
  • Aetna
  • CareFirst
  • Cigna
  • First Health
  • Geisinger Health Plan
  • HealthSmart/Accel
  • Johns Hopkins Health Plans
  • MultiPlan
  • Pennsylvania's Preferred Health Networks (PPHN)
  • Point Comfort Underwriters
  • Private Healthcare Systems (PHCS)
  • Veteran Affairs Community Care Network (Optum-VACCN)

Ratings & Reviews

4.9 out of 5

88 ratings, 33 reviews

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

Overall Rating by Patient
Provider Listened Carefully
Provider Explained Things Clearly
Provider Knew Medical History
Provider Showed Respect
Provider Spent Enough Time
Search reviews
    5 out of 5 stars
    Reviewed on 3/6/2026

    Dr. Hann is wonderful! Great care as well as great bedside manner care!

    5 out of 5 stars
    Reviewed on 3/6/2026

    Dr Hann is very knowledgeable, responsive, experienced, empathetic. She's great to work with and provides excellent care.

    5 out of 5 stars
    Reviewed on 2/27/2026

    Dr Hann was very courteous and very professional. I was very pleased and impressed.

    5 out of 5 stars
    Reviewed on 2/6/2026

    Excellent!

    5 out of 5 stars
    Reviewed on 2/5/2026

    Dr Hann was wonderful. Very compassionate and caring in both listening and explaining diagnosis thoughts and alternatives. Her care was comforting and took time to answer all questions and explain a very complex issues in plain English. She is obviously an expert and we are blessed to have been referred to her.

    5 out of 5 stars
    Reviewed on 2/2/2026

    Enjoy meeting with her

    5 out of 5 stars
    Reviewed on 1/16/2026

    Dr Hann is wonderful- she is attentive, caring and a great listener

    5 out of 5 stars
    Reviewed on 1/12/2026

    Annually I am scheduled for a CT scan Thereafter I speak with Christine Hann to discuss results of scan. Because of the distance between my home and the Dr.'s office, we speak by phone regarding the results

    5 out of 5 stars
    Reviewed on 1/9/2026

    Very thorough and compassionate!

    5 out of 5 stars
    Reviewed on 1/8/2026

    Knowledgeable, caring, trying to the best for my treatment, listening

    5 out of 5 stars
    Reviewed on 12/31/2025

    Dr. Hann is always very empathetic as well as professional.

    5 out of 5 stars
    Reviewed on 12/31/2025

    Dr. Hann was very caring. It was my initial consultation & I was pleased with her knowledge about this awful disease.

    5 out of 5 stars
    Reviewed on 12/29/2025

    Dr Hann is an excellent physician. She take time to make sure I understand what has been said and answers any and all questions I have.

    5 out of 5 stars
    Reviewed on 12/29/2025

    Nice, professional

    5 out of 5 stars
    Reviewed on 12/22/2025

    She's wonderful!

    5 out of 5 stars
    Reviewed on 12/22/2025

    Very knowledgeable and answered all my questions

    5 out of 5 stars
    Reviewed on 12/22/2025

    Dr Hann is is very caring and knowledgeable provider and a terrific listener. She very much cares for and respects her patients and sympathized with them during a very difficult time.

    5 out of 5 stars
    Reviewed on 12/5/2025

    Caring, knowledgeable, positive, smart, kind

    5 out of 5 stars
    Reviewed on 12/5/2025

    Excellent. Caring and knowledgeable. Clearly communicates. Takes time needed.

    5 out of 5 stars
    Reviewed on 11/24/2025

    I find Dr. Hann helpful and kind. I trust her.

    5 out of 5 stars
    Reviewed on 11/17/2025

    Excellent Physician. Listens and provides detailed information.

    5 out of 5 stars
    Reviewed on 11/10/2025

    Dr Hann and [staff] were very attentive and kind

    5 out of 5 stars
    Reviewed on 10/31/2025

    My new provider made me feel comfortable with my visit with her. She answered my questions I needed to know .

    5 out of 5 stars
    Reviewed on 10/20/2025

    Very good

    5 out of 5 stars
    Reviewed on 10/2/2025

    Dr. Hann is the best there is. She has taken such good care of me. She is not only extremely professional, she is also completely down to Earth. Actually there is no doubt in my mind that she saved my life.

    5 out of 5 stars
    Reviewed on 9/22/2025

    Very good

    5 out of 5 stars
    Reviewed on 9/18/2025

    Christine was very personable, easy to talk to and she is very smart about the cancer I have and easy to work with.

    5 out of 5 stars
    Reviewed on 8/18/2025

    Knowledgeable, empathetic, kind, prepared with approaches that are best for the patient. A good listener with ready suggestions. The very best. Glad Dr. Hann is my physician.

    5 out of 5 stars
    Reviewed on 7/28/2025

    Dr. Hann has and always will be my first person to consult in my decisions. She's the best . She cares about her patients.

    5 out of 5 stars
    Reviewed on 7/25/2025

    I love my oncologist.

    5 out of 5 stars
    Reviewed on 7/14/2025

    I have the greatest trust in Dr. Hann. She has always been respectful and helpful.

    5 out of 5 stars
    Reviewed on 7/3/2025

    Dr Hann is always open and helpful about my condition

    5 out of 5 stars
    Reviewed on 6/30/2025

    Dr. Hann Is an excellent physician.