Highlights
Age Groups Seen
- Young Adult 18-25
- Adult 26-64
- Older Adult 65+
Languages
- English
In-Network Plans
View All Accepted Plans (12)Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Christian Gocke
Primary Academic Title
Assistant Professor of Oncology
Johns Hopkins Physician
Find a Clinical Trial
View all trials by this principal investigator.
Contact for Research Inquiries
1650 Orleans St.
CRB I, Room 388
Baltimore, MD 21287
Phone: (410) 955-8839
Research Interests
epigenetics, multiple myeloma disease progression, stem cell biology
Research Summary
The goal of our laboratory is to elucidate the basic mechanisms responsible for multiple myeloma disease relapse and progression and translate these laboratory findings into novel and effective therapies. We have investigated regulators of tumor initiation and self-renewal that are required tumor regrowth after treatment. We have found that a novel inhibitor of RAS signaling can target myeloma stem cell activity. In addition, we have identified regulators of protein translation as critical mediators of chemoresistance and self-renewal. We are currently working to develop better models to study RAS function in multiple myeloma and to develop novel methods of targeting patients with RAS-mutated multiple myeloma. We are also working to identify novel inhibitors/targets that mediate myeloma relapse by promoting stem cell functions.
PubMed - Publications
https://www.ncbi.nlm.nih.gov/pubmed/?term=Gocke+CB+or+%5BGocke+C+and+Baker%5D
Selected Publications
Gocke CB, McMillan R, Wang Q, Begum A, Penchev VR, Ali SA, Borrello I, Huff CA, Matsui W. IQGAP1 Scaffold-MAP Kinase Interactions Enhance Multiple Myeloma Clonogenic Growth and Self-Renewal. Mol Cancer Ther. 2016 Nov;15(11):2733-2739. PubMed PMID: 27573425; PubMed Central PMCID: PMC5097000.
Gocke CB, Yu H. ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. PLoS One. 2008 Sep 22;3(9):e3255. PubMed PMID: 18806873; PubMed Central PMCID: PMC2532748
Alonso S, Hernandez D, Chang YT, Gocke CB, McCray M, Varadhan R, Matsui WH, Jones RJ, Ghiaur G. Hedgehog and retinoid signaling alters multiple myeloma microenvironment and generates bortezomib resistance. J Clin Invest. 2016 Dec 1;126(12):4460-4468. PubMed PMID: 27775549; PubMed Central PMCID: PMC5127663
Park EH, Soori M, Wang Q, Gondek L, Matsui W, Gocke CB. Protein Synthesis Rates Regulate Tumor-Initiating Potential and Chemoresistance in Multiple Myeloma. Abstract #4390. 59th ASH Annual Meeting & Exposition; 2017 December; Atlanta, GA
Yang M, Gocke CB, Luo X, Borek D, Tomchick DR, Machius M, Otwinowski Z, Yu H. Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell. 2006 Aug 4;23(3):377-87. PubMed PMID: 16885027
Honors
- Young Investigator Award, Conquer Cancer Foundation of ASCO, 7/1/15
- Member, Alpha Omega Alpha Honor Society, 6/1/08
Memberships
- American Society of Hematology
- American Society of Clinical Oncology
- American Association for Cancer Research
Locations
- Sidney Kimmel Comprehensive Cancer Center
- 401 North Broadway Street, Weinberg BLDG, Baltimore, MD 21287
- Get Directions
- phone: 410-955-8964
- fax: 410-367-2194
Expertise
Education
- Fellowship: Johns Hopkins University School of Medicine, Oncology, 2016
- Residency: Johns Hopkins University School of Medicine, Internal Medicine, 2012
- Graduate School: University of Texas Southwestern at Dallas, PhD, 2009
- Medical Education: University of Texas Southwestern at Dallas, MD, 2009
Board Certifications
- Hematology: American Board of Internal Medicine, 2015
Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
4.8 out of 5
112 ratings, 39 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 4 out of 5 starsReviewed on 3/9/2026
Dr Gocke stays on point with my Dx and not rush to tx prematurely. I truly thank him for that!
- 5 out of 5 starsReviewed on 2/25/2026
Dr. Gocke provides responsive & excellent care.
- 5 out of 5 starsReviewed on 2/11/2026
Great dr
- 5 out of 5 starsReviewed on 2/9/2026
Explained everything very well. Showed compassion and concern. Very positive meeting.
- 5 out of 5 starsReviewed on 2/2/2026
Very good and professional
- 5 out of 5 starsReviewed on 1/14/2026
Dr Gocke and PA reviewed my history to determine next steps. Currently in remission but their recommendation is to restart immunotherapy. This should help with staying In remission longer. Next apppointment will determine how to proceed.
- 5 out of 5 starsReviewed on 1/12/2026
Although I stated my appt started late, Dr. Gocke more than made up for it with the time he doesn't with me once my time started. He was patient, answered my questions and knew I had a list of questions and wanted to answer them all.
- 5 out of 5 starsReviewed on 1/7/2026
I enjoy coming to John's Hopkins,everything is always good at this hospital
- 5 out of 5 starsReviewed on 12/31/2025
I feel very well cared for bu this practice.
- 5 out of 5 starsReviewed on 12/29/2025
Provider listened to my concerns, gave me opportunity to asked questions and he was very patient.
- 5 out of 5 starsReviewed on 12/22/2025
Very attentive, personable, warm, knowledgeable, took my concerns seriously, thorough, answered every question.
- 5 out of 5 starsReviewed on 12/17/2025
All good. Very, very fortunate to be under Dr. Gocke's care.
- 5 out of 5 starsReviewed on 12/17/2025
All aspects were professional
- 5 out of 5 starsReviewed on 12/10/2025
Dr Gocke was great. He gave an explanation of my cancer, the possibility of treatment, eased my anxieties. He was there for ME.
- 5 out of 5 starsReviewed on 12/10/2025
Good doctor
- 5 out of 5 starsReviewed on 12/3/2025
Even though the Dr. Was late for the video appointment he did apologized right away.
- 5 out of 5 starsReviewed on 11/24/2025
Dr. Gocke is the absolute best provider. He has pulled me from a dire Cancer diagnosis in March 2025 to a current complete remission . I have absolute faith that he'll navigate a positive course through this disease. Don't let him get away!
- 5 out of 5 starsReviewed on 11/24/2025
Was very attentive and helped explain the options we would have going forward for treatment based on my personal progress not the generic protocols..
- 5 out of 5 starsReviewed on 11/19/2025
Dr. Gocke, is always so professional and knowledgeable about my illness. He and his team are always a phone call away. I seem to have the greatest team. They get right back to me if there is a problem with my meds or anything.
- 5 out of 5 starsReviewed on 10/15/2025
The provider as well as this diagnosis is new to me. I feel confident Dr. Gocke will be honest with me every step of the way with my treatments.
- 5 out of 5 starsReviewed on 9/29/2025
Dr. Explained everything in language a regular person could understand.
- 5 out of 5 starsReviewed on 9/29/2025
Very attentive and did a good job of covering what things were going to happen and why
- 5 out of 5 starsReviewed on 9/22/2025
Dr. Gocke and his team are highly competent professionals. They were very diligent in adhering to the study protocols, while maintaining compassion for my health challenge.
- 5 out of 5 starsReviewed on 9/15/2025
Dr. Gocke was very professional and very professional.
- 5 out of 5 starsReviewed on 9/10/2025
Dr Gocke continues to explain test results to my understanding and cautiously research the best treatment for me when it is time to start for my diagnosis.
- 4 out of 5 starsReviewed on 9/8/2025
I don't think he understood the results of my latest adaquatly
- 5 out of 5 starsReviewed on 9/8/2025
Always excellent
- 5 out of 5 starsReviewed on 7/30/2025
Provides excellent & responsive treatment.
- 5 out of 5 starsReviewed on 7/30/2025
Dr. Gocke is great!
- 5 out of 5 starsReviewed on 7/28/2025
I only worked with the doctor
- 5 out of 5 starsReviewed on 7/7/2025
New doctors/teams for recent myeloma diagnosis.
- 5 out of 5 starsReviewed on 7/7/2025
Excellent service and professionalism
- 5 out of 5 starsReviewed on 7/7/2025
Outstanding patient support
- 4 out of 5 starsReviewed on 6/11/2025
Good
- 4 out of 5 starsReviewed on 5/28/2025
Very good
- 5 out of 5 starsReviewed on 5/27/2025
Dr G is very thoughtful and thorough.
- 4 out of 5 starsReviewed on 5/21/2025
Talking about my health with someone who truly understood the disease I was dealing with made me feel reassured and supported.
- 5 out of 5 starsReviewed on 4/30/2025
Very friendly, courteous and professional !
- 5 out of 5 starsReviewed on 4/28/2025
Dr.,Gocke is personable & very helpful.