Chan-Hyun Na, MS, PhD
Highlights
Languages
- English
Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Chan-Hyun Na
Professional Titles
Director, the Center for Proteomics Discovery
Primary Academic Title
Associate Professor of Neurology
Background
Chan-Hyun Na, Ph.D., has extensive experience in mass spectrometry-based proteomics, imaging mass spectrometry, bioinformatics, and computer programming. Also, he has been trained in molecular biology and neurodegenerative disorders. He obtained his Ph.D. from POSTECH, South Korea, and then he moved to Konkuk University, South Korea, where he established and optimized imaging mass spectrometry for biomarker discovery from renal cell carcinoma tissues. Subsequently, he joined Emory University, where he developed various proteomics methods using Fourier Transform-based mass spectrometry to study ubiquitin biology. After joining Johns Hopkins University, he has been involved in applying proteomics technologies for discovering biomarkers and disease mechanisms of various neurodegenerative diseases, elucidating novel protein-protein interactions in a variety of contexts, identifying cryptic open reading frames encoded in the human genome, and identifying long-lived synaptic proteins by measuring turnover of synaptosome proteins. In addition, he served as research director of the Center for Proteomics Discovery, Johns Hopkins University School of Medicine, completing over 120 proteomics projects successfully.
Centers and Institutes
Institute for Cell Engineering
Contact for Research Inquiries
chanhyun@jhmi.edu
Research Interests
Proteomics, Mass Spectrometry, Biomarkers, Cell-type-specific proteomics, Single-cell proteomics, Metabolomics, Lipidomics, etc.
Lab Website
Translational Proteomics - Lab Website
Dr. Na's lab is applying proteomics technologies for diverse biological questions including discovering biomarkers and disease mechanisms of various neurodegenerative diseases and studying cryptic open reading frames in the context of their involvement in various diseases.
Core Facility
Research Summary
His laboratory has primarily focused on developing novel proteomics technologies and applying mass spectrometry-based proteomics/metabolomics technologies to various biomedical studies. The representative proteomics technology we developed is an in-situ cell-type-specific proteomics method using antibody-mediated biotinylation (iCAB), with which cell-type-specific proteome analysis can be achieved for any tissues with specific marker proteins without the need for genetic modification or an expensive instrument. The application to biomedical studies includes discovering noncanonical aberrant proteins involved in various diseases, pathogenesis pathways, and biomarkers. For the discovery of noncanonical aberrant proteins involved in various diseases, he is incorporating genomics or transcriptomics data with proteomics data to discover proteins that are not annotated in reference protein databases. For the discovery of pathways involved in various diseases, he identifies differentially regulated proteins, post-translational modifications, interacting proteins, and metabolites/lipids in biological samples occurring during the pathogenesis process in collaboration with various laboratories at Johns Hopkins. For the biomarker discoveries, he identifies candidate biomarkers in human biological fluids, such as human cerebrospinal fluid and serum, using discovery proteomics approaches and validates them using targeted proteomics approaches.
Google Scholar - Publications
PubMed - Publications
Selected Publications
- Oh S, Jung J, Kim J, Jang Y, Bakker CC, Pantelyat AY, #Zhang Z, #Dawson TM, #Na CH, #Rosenthal LS. Discovery and validation of biomarkers for Parkinson’s disease from human cerebrospinal fluid using mass spectrometry-based proteomics analysis. EBioMedicine. 2025 2025 Aug;118:105844. doi: 10.1016/j.ebiom.2025.105844. Epub 2025 Aug 5. #Corresponding authors
- Park C, Ryu T, Mohamed-Hinds R, Kim K, Kim J, Zou L, Williams B, #Na CH, #Chao W. Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients. Sci Rep. 2025 Jul 1;15(1):21871. doi: 10.1038/s41598-025-06430-x. PMID: 40596376. #Corresponding authors
- Ryu T, Kim SY, Thuraisamy T, Shin J, Jang Y, Kam TI, #Na CH. In-Depth Cell-Type-Specific Proteome Landscape of the Brain from Human Amyloid-β Overexpression Mouse Model. Adv Sci (Weinh). 2025 May 8:e2409318. doi: 10.1002/advs.202409318. Online ahead of print. PMID: 40345165 #Corresponding Authors
- Ryu T, Adler BL, Jeong SJ, Lee DC, Hoke A, #Na CH, #Chung T. Quantitative serum proteomic analysis for biomarker discovery in post-COVID-19 postural orthostatic tachycardia syndrome (PC-POTS) patients. Auton Neurosci. 2025 Apr;258:103247. doi: 10.1016/j.autneu.2025.103247. Epub 2025 Feb 8. PMID: 40022872 #Corresponding Authors
- Jang Y, Oh S, Hall AJ, Zhang Z, Tropea TF, Chen-Plotkin A, Rosenthal LS, #Dawson TM, #Na CH, #Pantelyat AY Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid. Clin Proteomics. 2024 Sep 28;21(1):56. doi: 10.1186/s12014-024-09507-3. PMID: 39342078 #Corresponding Authors
Expertise
Education
- Pohang University of Science and Technology, Ph.D., 2007
- Pohang University of Science and Technology, M.S., 2001
- Soonchunhyang University, B.S., 1999