Brett Morrison, MD

Primary Academic Title

Associate Professor of Neurology

Background

Centers and Institutes

• Amyotrophic Lateral Sclerosis (ALS) Clinic
• Muscular Dystrophy Center

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Contact for Research Inquiries

855 N. Wolfe Street
Rangos 248
Baltimore, MD 21205

Research Summary

Dr. Morrison's research interests include investigations into the cellular mechanisms of nerve regeneration and common peripheral neuropathies, with a particular focus on the role of cellular metabolism. Current research focuses on better understanding the role of the immune system in peripheral nerves and targeting these pathways for the development of new treatments.

PubMed - Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=morrison%2C+brett

Selected Publications

• Lee, Y.*, Morrison, B.M.*, Li, Y., Lengacher, S., Farah, M.H., Hoffman, P.N., Liu, Y., Tsingalia, A., Jin, L., Zhang, P-W., Pellerin, L., Magistretti, P.J., Rothstein, J.D.  Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature 2012; 487 (7408): 443-448. *Co-First author of publication
• Jha, M.K., Lee, Y., Russell, K.A., Yang, F., Dastgheyb, R.M., Deme, P. Ament, X.H., Chen, W., Liu, Y., Guan, Y., Polydefkis, M.J., Hoke, A., Haughey, N.J., Rothstein, J.D., Morrison, B. M.*  Monocarboxylate transporter 1 in Schwann cells contributes to the maintenance of sensory nerve myelination during aging. Glia 2020; 68 (1): 161-77.
• Jha, M.K., Ament, X.H., Yang, F., Liu, Y., Polydefkis, M.J., Pellerin, L., Morrison, B.M. Reducing monocarboxylate transporter 1 MCT1 worsens experimental diabetic peripheral neuropathy. Exp. Neurol. 2020; 330 113415.
• Philips, T., Mironova, T.A., Jouroukhin, Y., Chew, J., Vidensky, S., Farah, M., Pletnikov, M.V., Bergles, D.E., Morrison, B.M.*, Rothstein J.D.  MCT1 deletion in oligodendrocyte lineage cells causes late-onset hypomyelination and axonal degeneration. Cell Reports 2021; 34: 108610. *Co-corresponding author
• Jha, M.K., Passero, J.V., Rawat, A., Ament, X.H., Yang, F., Vidensky, S., Collins, S.L., Horton, M.R., Hoke, A., Rutter, G.A., Latremoliere, A., Rothstein, J.D., Morrison, B.M. Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after nerve injury. J. Clin. Invest. 2021: 131 (21):e141964

Honors

• Young Investigator Award, Passano Foundation, 1/1/06
• Jay Slotkin Research Award, Johns Hopkins Hospital, 1/1/05
• Inductee into Alpha Omega Alpha Honor Society, 1/1/00
• Doctoral Dissertation Award, Mount Sinai School of Medicine, 1/1/99
• Morris Bender Award in Clinical Neurology, 1/1/99
• Research Grant, Amyotrophic Lateral Sclerosis Association, 1/1/96
• Magna Cum Laude in Neuroscience, Amherst College, 1/1/92
• James Olds Memorial Neuroscience Award, Amherst College, 1/1/92
• Inductee into Sigma Xi Honor Society, 1/1/92