Argye Elizabeth Hillis, MD

Professional Titles

• Director, Center of Excellence in Stroke Detection and Diagnosis, Sheikh Khalifa Stroke Institute
• Sheikh Khalifa Stroke Institute Professor of Acute Stroke Diagnoses and Management
• Director, Cerebrovascular Division of Neurology
• Executive Vice Chair, Department of Neurology

Primary Academic Title

Professor of Neurology

Background

Centers and Institutes

Cerebrovascular Center

CV

https://www.hopkinsmedicine.org/-/media/profiles-support/cvs/hillis.pdf

Find a Clinical Trial

Videos

• #TomorrowsDiscoveries: Recovering After a Stroke - Argye Hillis, M.D.

• The Johns Hopkins Hospital Comprehensive Stroke Center

Recent News Articles and Media Coverage

• Argye Hillis Among Stoke Researchers Awarded $11 Million NIH Grant Press Release (4/20/16)

  Dealing with the emotional aspects of stroke rehab, Philadelphia Inquirer (04/13/2014)

  Why You Get the Joke: Brain's Sarcasm Center Found, Live Science

Additional Academic Titles

Professor of Physical Medicine and Rehabilitation

Research Interests

Cognitive Deficits and Recovery after Right Hemisphere Stroke, Language Recovery After Stroke, Stroke Cognitive Outcome and Recovery (SCORE)

Lab Website

S.C.O.R.E. Lab - Lab Website

• The mission of the Stroke Cognitive Outcomes and Recovery (S.C.O.R.E.) Lab is to enhance knowledge of brain mechanisms that allow people recover language, empathy, and other cognitive and communicative functions after stroke, and to improve ways to facilitate recovery of these functions after stroke. We also seek to improve the understanding of neurobiology of primary progressive aphasia., and how to enhance communication in people with this group of clinical syndromes.

Research Summary

Following a stroke, an individual may experience speech, language, cognitive, or emotional problems. Dr. Hillis’ current research aims to improve the understanding of how language and other cognitive functions are represented and carried out in the brain, how they recover after injury, and how understanding these processes can contribute to evaluation and treatment of stroke and dementia. Specifically, current research studies include the following:

• Stroke Cognitive Outcome and Recovery (SCORE)
• Language Recovery After Stroke
• Cognitive Deficits and Recovery after Right Hemisphere Stroke

Dr. Hillis' current research combines longitudinal task-related and task-free functional imaging and structural imaging from the acute stage of stroke through the first year of recovery, with detailed cognitive and language assessments to improve our understanding how language and other cognitive functions recover after stroke. Her other avenue of research involves novel treatment studies and longitudinal imaging and language studies of Primary Progressive Aphasia. She has published extensively on these topics in journals and textbooks.

Google Scholar - Publications

http://scholar.google.com/scholar?q=Argye+E+Hillis&btnG=&hl=en&as_sdt=0%2C21

PubMed - Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=hillis%2C+argye

Selected Publications

• SELECTED PUBLICATIONS (from >150 total)
  
  Hillis, A.E. (1989). Efficacy and generalization of treatment for aphasic naming errors. Archives of Physical Medicine and Rehabilitation, 70, 632-636.
  
  Caramazza, A. & Hillis, A.E. (1991). Lexical organization of nouns and verbs in the brain. Nature, 349,788-90.
  
  Hillis, A.E. & Caramazza, A. (1991). Category-specific naming and comprehension impairment: A double dissociation. Brain, 114, 2081-2094.
  
  Hillis, A.E. & Caramazza, A. (1995). Cognitive and neural mechanisms underlying visual and semantic processing. Journal of Cognitive Neuroscience, 7, 457-478.
  
  Hillis, A.E. & Caramazza, A. (1995). The representation of grammatical categories of words in the brain. Journal of Cognitive Neuroscience, 7, 396-407.
  
  Hillis, A.E., Boatman, D., Hart, J. & Gordon, B. (1999). Making sense out of jargon: a neurolinguistic and computational account of jargon aphasia. Neurology, 53, 1813-1824.
  
  Hillis, A.E., Wityk, R.J., Tuffiash, E., Beauchamp, N.J., Jacobs, M.A., Barker, P.B., Selnes, O.A. (2001). Hypoperfusion of Wernickes area predicts severity of semantic deficit in acute stroke. Annals of Neurology, 50, 561-566.
  
  Hillis, A.E., Wityk, R.J., Barker, P.B., Beauchamp, N.J., Gailloud, P., Murphy, K., Cooper, O., Metter, E.J. (2002). Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion, Brain,125, 1094-1104.
  
  Hillis, A.E., Tuffiash, E. & Caramazza, A. (2002). Modality specific deterioration in oral naming of verbs. Journal of Cognitive Neuroscience, 14, 1099-1108.
  
  Hillis, A.E., Wityk, R., Barker, P.B., Caramazza, A. (2003). Neural regions essential for writing verbs. Nature Neuroscience, 6, 19-20.
  
  Hillis, A.E., Oh, S., Ken, L. (2004). Deterioration of naming nouns versus verbs in primary progressive aphasia. Annals of Neurology, 55, 268-275.
  
  Hillis, A.E., Work, M., Breese, E.L., Barker, P.B., Jacobs, M.A. & Maurer, K. (2004). Re-examining the brain regions crucial for orchestrating speech articulation. Brain, 127, 1479-1487.
  
  Hillis, A.E., Newhart, M., Heidler, J., Barker, P.B., Herskovits, E., and Degaonkar, M. (2005). The roles of the visual word form area in reading. NeuroImage, 24, 548-559.
  
  Reineck, L., Agarwal, S. & Hillis, A.E. (2005). The diffusion-clinical mismatch predicts early language recovery in acute stroke. Neurology, 64, 828-833.
  
  Hillis, A.E., Newhart, M., Heidler, J., Barker, P.B., Degaonkar, M. (2005). Anatomy of spatial attention: insights from perfusion imaging and hemispatial neglect in acute stroke. Journal of Neuroscience, 25, 3161-7.
  
  Charles, R. & Hillis, A.E. (2005). Posterior Cortical Atrophy: clinical presentation and cognitive deficits compared to Alzheimers Disease. Behavioural Neurology, 16, 15-23.
  
  Hillis, A.E., Heidler-Gary, J., Newhart, M., Chang, S., Ken, L. & Bak, T. (2006). Naming and comprehension in primary progressive aphasia: the influence of grammatical word class. Aphasiology, 20, 246-256.
  
  Newhart, M., Ken, L., Kleinman, J.T., Heidler-Gary, J., & Hillis, A.E. (2007). Neural networks essential for naming and word comprehension. Cognitive and Behavioral Neurology, 20, 25-30.
  
  DeLeon, J., Gottesman, R.F., Kleinman, J.T., Newhart, M., Davis, C., Lee, A., Hillis, A.E. (2007) Neural regions essential for distinct cognitive processes underlying picture naming. Brain, 130, 1408-22.
  
  Heidler-Gary, J. & Hillis, A.E. (2007). Distinctions between the dementia in Amyotrophic Lateral Sclerosis with Frontotemporal Dementia and the dementia of Alzheimer''s Disease. Amyotrophic Lateral Sclerosis.
  
  Philipose, L.E., Gottesman, R.F., Newhart, M.; Kleinman, J.T.; Herskovits, E.H.; Pawlak, M.A., Marsh, E.B.; Davis, C.; Heidler-Gary, J.; Hillis, A.E. (2008). Neural regions essential for reading and spelling of words and pseudowords. Annals of Neurology. 481-492.
  
  Cloutman, L., Gottesman, R., Chaudhry, P., Davis, C., Kleinman, J.T., Pawlak, M., Herskovits, E.H., Kannan, V., Lee, A., Newhart, M., Heidler-Gary, J., Hillis, A.E. (2008)Where (in the brain) do semantic errors come from? Cortex. [Epub ahead of print]
  
  Medina, J., Kannan, V., Pawlak, M., Kleinman, J.T., Newhart, M., Davis, C., Heidler-Gary J.E., Herskovits,
  E.H., Hillis, A.E. (2008) Neural substrates of visuospatial processing in distinct reference frames: evidence from unilateral spatial neglect. Journal of Cognitive Neuroscience. [Epub ahead of print].
  
  Cloutman, L., Gingis, L., Newhart, M., Davis, C., Heidler-Gary, J., Crinion, J., Hillis, A.E. (in press). A neural
  network critical for spelling. Annals of Neurology.

Honors

• Alpha Omega Alpha
• Phi Beta Kappa
• Research Fellow, National Stroke Association
• Fellow, American Heart Association
• Fellow, American Stroke Association
• Derek Denny-Brown Neurological Scholar Award, American Neurological Association
• Norman Geschwind Award in Behavioral Neurology, American Academy of Neurology
• Baltimore Top Docs 2015, Baltimore Magazine, 1/1/15
• Best Doctors in America, 1/1/14

Memberships

• Academy of Aphasia
• American Academy of Neurology, Section on Behavioral Neurology
• American Heart Association Stroke Council, Fellow;Abstract Reviewer for the International Stroke Conference (2003-2007); Scientific Session Chair, 2005, 2006
• American Neurological Association, Scientific Program Committee (2004-2006)
• Clinical Aphasiology Conference, Program committee 1985, 1992; Program Chair 2003; Conference Chair 2004; Steering Committee (2003-present)
• Faculty 1000 Medicine, Evaluation Board
• Society for Neuroscience
• World Federation of Neurology- Research Group on Aphasia and Cognitive Disorders, Chair, 2004-2008
• American Speech Language Association,

  Advances in Diagnosis, Treatment, and Prognosis of Primary Progressive Aphasia