Andreas Patsalos, PhD

Assistant Professor of Medicine

https://www.linkedin.com/in/andreas-patsalos/

https://x.com/anpatsalos

apatsalos@jhmi.edu

Inflammation, Tissue Repair, Skeletal Muscle, Macrophage Biology, Transcriptional Regulation

https://ifbr.jhmi.edu/andreas-patsalos-phd

Dr. Patsalos’s research is focused on the molecular and cellular mechanisms of tissue repair, particularly in the context of regenerative inflammation. He investigates macrophage subtype specification, the transcriptional landscape in muscle injury and dystrophy, and the role of key transcription factors and growth factors. His work aims to improve muscle regeneration by modulating the immune response and exploring novel therapeutic approaches for treating muscular dystrophy and other debilitating injuries.

https://scholar.google.com/citations?user=l67qKr8AAAAJ&hl=en

• Patsalos A, Halasz L, Oleksak D, Wei X, Nagy G, Tzerpos P, Conrad T, Hammers DW, Sweeney HL, Nagy L. Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture. J Clin Invest. 2024 Aug 27:e173858. doi: 10.1172/JCI173858.
• Patsalos A, Halasz L, Medina-Serpas MA, Berger WK, Daniel B, Tzerpos P, Kiss M, Nagy G, Fischer C, Simandi Z, Varga T, Nagy L. A growth factor-expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15. J Exp Med. 2022 Jan 3;219(1):e20210420. doi: 10.1084/jem.20210420.
• Patsalos A, Tzerpos P, Wei X, Nagy L. Myeloid cell diversification during regenerative inflammation: Lessons from skeletal muscle. Semin Cell Dev Biol. 2021 Nov;119:89-100. doi: 10.1016/j.semcdb.2021.05.005.
• Patsalos A, Tzerpos P, Halasz L, Nagy G, Pap A, Giannakis N, Lyroni K, Koliaraki V, Pintye E, Dezso B, Kollias G, Spilianakis CG, Nagy L. The BACH1-HMOX1 Regulatory Axis Is Indispensable for Proper Macrophage Subtype Specification and Skeletal Muscle Regeneration. J Immunol. 2019 Sep 15;203(6):1532-1547. doi: 10.4049/jimmunol.1900553.
• Giannakis N*, Sansbury BE*, Patsalos A*, Hays TT, Riley CO, Han X, Spite M, Nagy L. Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration. Nat Immunol. 2019 May;20(5):626-636. (*Co-first author).

• Co-Inventor, "Thiazolidinedione for the treatment of muscular dystrophies." Patent: PCT/US2023/025437; Publication date: December 21, 2023.

• Co-Inventor, "Pro-resolving mediators for muscle injury." PHS Patents reference: BWH 25386 - JHU D15686; Filed: December 5, 2018.

• Recipient of the 2023 Phileleftheros Cyprus National Newspaper's inaugural awards, “Άριστους των Αρίστων”, recognizing the top 10 Cypriot individuals with outstanding contributions to science or arts in 2023.

• Best Abstract in Basic Science Research, 11th Annual Johns Hopkins All Children’s Research Symposium 2022, St Petersburg, FL, USA.

• Basic Research Fellow Finalist, W. Leigh Thompson Excellence in Research, Johns Hopkins 2021 Department of Medicine/Whiting School of Engineering Research Retreat, Baltimore, MD, USA.

• Best Abstract in Basic Science Research, 9th Annual Johns Hopkins All Children’s Research Symposium 2020, St Petersburg, FL, USA.

• Award for Outstanding Poster Presentation, 2018 Single Cell Genomics Symposium, USF, Tampa, FL, USA.

• Foreign Travel Grant Award, 2017 Advances in Skeletal Muscle Biology in Health and Disease Conference, Gainesville, FL; Poster selected for oral presentation.  

• NIH Travel Award for Outstanding Poster Presentation, 2016 New Directions in Biology and Disease of Skeletal Muscle Conference, Orlando, FL, USA. 

• Hellenic Society for Biochemistry and Molecular Biology (HSBMB), 2013-present.
• World Hellenic Biomedical Association (WHBA), 2013-present.
• Hellenic Bioscientific Association of the USA (HBA), 2017-present.
• American Society for Biochemistry and Molecular Biology (ASBMB), 2018-present.
• American Association of Immunologists (AAI), 2019-present.
• Single Cell Spatial Analysis Program (SCSAP) at the University of Michigan, 2023-present.
• Orthopaedic Research Society (ORS), 2024-present.

• Editorial Leadership

  • Topic Editor, Frontiers in Immunology (2023-Present).

  • Guest Editor, Frontiers in Immunology, Special Issue: "Transcriptional Regulation of Macrophage Function" (2022-2023).

• Institutional & Professional Service

  • Co-organizer, semi-annual JHACH Vice Dean’s Lectureship Award (2025-Present).

  • Reviewer, JHACH Cancer and Blood Disorders Institute (CBDI) Research Council (2025-Present).

  • Research and Education Committee Member and Reviewer, ORS Preclinical Model (PCM) section (2024-Present).

  • Member, USF Biotechnology MSc Thesis Evaluation Committee (2024).

  • Member, JHACH/JHU Postdoctoral Advisory Committee (2018-2022).

• Peer Review Service

  • Ad Hoc Reviewer for over 20 international peer-reviewed journals (2018-Present).

  • Selected Journals: Journal of Clinical Investigation, iScience, Frontiers in Immunology, Scientific Reports, Cells, and International Journal of Molecular Sciences.