Ami Shah, MD

Professional Titles

• Director, Division of Rheumatology, Department of Medicine
• Co-Director, Johns Hopkins Scleroderma Center
• Deputy Director, Rheumatology Precision Medicine Centers of Excellence Clinical Programs

Primary Academic Title

Professor of Medicine

Background

Centers and Institutes

Scleroderma Center

Find a Clinical Trial

Research Interests

Cancer Immune Related Adverse Events, Connection Between Cancer and Autoimmunity in the Rheumatic Diseases, Methods to Detect Cardiopulmonary Complications in Scleroderma, Scleroderma and Raynaud’s Phenomenon

Lab Website

Ami Shah Lab - Lab Website

• Researchers in the Ami Shah Lab study scleroderma and Raynaud's phenomenon. We examine the relationship between cancer and scleroderma, with a focus on how and if cancer causes scleroderma to develop in some patients. We are currently conducting clinical research to study ways to detect cardiopulmonary complications in patients with scleroderma, biological and imaging markers of Raynaud's phenomenon, and drugs that improve aspects of scleroderma.

Research Summary

Dr. Shah has an active research program studying various aspects of scleroderma and Raynaud’s phenomenon. She is investigating the connection between cancer and scleroderma, as her early data suggest cancer may drive the development of scleroderma in some patients. She also conducts epidemiological studies and participates in clinical trials to examine 1) methods to detect cardiopulmonary complications in scleroderma, 2) biological and imaging markers of Raynaud’s severity and 3) drugs that may improve various aspects of the disease (such as skin, lung or vascular complications).

PubMed - Publications

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40423376/?sort=date&direction=ascending

Selected Publications

• Shah AA, Casciola-Rosen L, Rosen A. Cancer-induced Autoimmunity in the Rheumatic Diseases. Arthritis Rheumatol. 2015 Feb;67(2):317-26. PMID: 25371098.

• Shah AA, Laiho M, Rosen A, Casciola-Rosen L. Protective Effect Against Cancer of Antibodies to the Large Subunits of Both RNA polymerases-I and -III in Scleroderma. Arthritis Rheumatol. 2019;71(9):1571-9. PMID: 30888702

• Shah AA, Rosen A, Hummers L, Wigley F, Casciola-Rosen L. Close Temporal Relationship Between Onset of Cancer and Scleroderma in Patients with RNA Polymerase I/III Antibodies. Arthritis Rheum. 2010 Sep; 62(9): 2787-95. PMID: 20506513

• Igusa T, Hummers LK, Visvanathan K, Richardson C, Wigley FM, Casciola-Rosen L, Rosen A, Shah AA. Autoantibodies and scleroderma phenotype define subgroups at high-risk and low-risk for cancer. Ann Rheum Dis. 2018;77(8):1179-1186. doi: 10.1136/annrheumdis-2018-212999. PMID: 296788941

• Joseph CG, Darrah E, Shah AA, Skora AD, Casciola-Rosen LA, Wigley FM, Boin F, Fava A, Thoburn C, Kinde I, Jiao Y, Papadopoulos N, Kinzler KW, Vogelstein B, Rosen A. Association of the autoimmune disease scleroderma with an immunologic response to cancer. Science. 2014 Jan 10;343(6167):152-7. PMID: 24310608.

Honors

• Edith Busch Prize for Young Investigators, Edith Busch Foundation and 5th Systemic Sclerosis World Congress
• Henry Kunkel Young Investigator Award, American College of Rheumatology
• Career Development Bridge Funding Award, American College of Rheumatology Research and Education Foundation and Arthritis Foundation, 1/1/11
• Delta Omega Alpha, Johns Hopkins Bloomberg School of Public Health, 1/1/10
• Clinical Investigator Fellowship Award, American College of Rheumatology Research and Education Foundation, 1/1/09
• Alpha Omega Alpha, Johns Hopkins University School of Medicine, 1/1/03
• Phi Beta Kappa, Massachusetts Institute of Technology, 1/1/99
• Burchard's Scholar, Massachusetts Institute of Technology, 1/1/98

Memberships

• American College of Rheumatology