Adrian Sandra Dobs, MD, MHS

Professional Titles

• Director, Johns Hopkins Clinical Research Network

Primary Academic Title

Professor of Medicine

Background

Centers and Institutes

• Klinefelter Syndrome Center
• Metabolism and Obesity Research, Center for
• Sidney Kimmel Comprehensive Cancer Center

Clinical Trial Keywords

Hormone replacement therapy men and women, hyperlipidemia, diabetes

Additional Academic Titles

Professor of Oncology

Contact for Research Inquiries

Phone: (443) 287-4000

Research Interests

Endocrinology, Gonadal dysfunction, hyperlipidemia, diabetes mellitus

Lab Website

Adrian Dobs Lab - Lab Website

• Researchers in the Adrian Dobs Lab study topics that include gonadal dysfunction, hyperlipidemia, diabetes mellitus, and the relationship between sex hormones and heart disease. We currently are investigating male gonadal function--with particular interest in new forms of male hormone replacement therapy--and hormonal changes related to aging.

Core Facility

Johns Hopkins Clinical Research Network (JHCRN)

Research Summary

Dr. Dobs is presently an active investigator in the field of sex hormone disorders and a clinical investigator who has published extensively in HIV-related endocrinopathies and risks and benefits of testosterone replacement therapies.

Selected Publications

• Research Support.
  
  Ongoing Research Support:
  RO1 DA1409801 (Dobs AS) 06/15/03 05/31/09
  NIDA/NIH Cognitive Consequences of Endocrine Dysfunction in Injection Drug Users
  Role: Principal Investigator
  The major goal of this project is to investigate the consequences of hypogonadal endocrine dysfunction in injection drug users with and without HIV.
  
  2U01 AI35042-07 (Margolick JB) 04/01/04 03/31/11
  NIAID/NIH Multi-Center AIDS Cohorts
  Role: Co-Investigator
  The major goal of this project is to determine metabolic abnormalities of HIV disease.
  
  R03DA026038 09/30/08 9/29/10
  Serum Sex Hormones and Cardiovascular Risk in the MACS
  The major goal of this project is to study the relationship of sex steroids to heart disease
  Principal Investigator
  
  Publications
  
  1. Paller CJ, Shiels MS,Rohrmann S, Basaria S, Rifai N, Nelson W, Platz EA, Dobs A, Relationship of Sex Streriod Hormones with Bone Mineral Density in a Nationally-Representative Sample of Men, Clin Endocrinol (Oxf) May 2008 (E-pub ahead of print) PMID 18485120

  2. Wohl D, Scherzer R, Heymensfield S, Simberkoff M, Sidney S, Bacchetti P, Grunfeld C:FRAM Study Investigators (including Dobs A), The Associations of Regional Adipose Tissue with Lipid and Lipoprotein Levels in HIV Infected Men, J Aquir Immune Defic Syndr. , May 2008 48 (1):44-52.

  3. Brown T, Jacobson L, Xu X, Tang Y, Qaqish R, Kingsley L, Palella F, Witt M, Visscher B, Dobs A, The Relationship Between Inflammatory Markers, the Metabolic Syndrome and Body Composition Among HIV Seropositive and Seronegative Men: Two Nested Case-Control Studies from the Multicenter AIDS Cohort Study, Conference on Retroviruses and Oppurtunistic Infections.

  4. Dobs A, Mortgentaler A, Does Testosterone Therapy Increase the Risk of Prostate Cancer?Endocr.Prac.,2008,14,7,904-911 PMID 18996823
  Eckman A, Dobs A, Drug-Induced Gynecomastia,Expert Opin.Drug Saf..,2008,7,6,691-702, England PMID 18983216

  5. Mortgentaler A, Dobs AS, Kaufman JM, Miner MM, Shsbsigh R, Swerdloff, RS, Wang C. Long Acting Testosterone Therapyin Men with Hypogonadism: Results of a Pharmacokinetic Clinical Study, JUrol.,2008,180,6,2307-2313,United States, PMID 18930255

  6. Ouyang P, Vaidya D, Dobs A, Golden S, Szklo M, Heckbert S, Kopp P, Gapstur S, Sex Hormone Levels and Subclinical Atherosclerosis , Atherosclerosis, 2008 PMID 18849030

  7. Andrade A, Hendrix C, Parsons T, Caballero B, Yuan C, Flexner C, Dobs A, Brown T, BMC Complementary and Alternative Medicine.,2008,8,50,England, PMID 18713456

  8. Vaidya D, Dobs A, Gapstur S, Golden S, Hankinson A, Liu K, Ouyang P, The Association of Endogenous Sex Hormones with Lipoprotein Subfraction Profile in the Multi-Ethnic Study of Atheroschlerosis, Metabolism, 2008,57,6,782-790, United States, PMID 18502260

  9. Pfeil E., Dobs A, Current and Future Testosterone Delivery Systems for Treatment of the Hypogonadal Male, Expert Opin. Drug Deliv., 2008 5,4,471-481, England, PMID 18426387

  10. Cofrancesco J, Scherzer R, Tien P, Gilbert C, Southwell H, Sidney S, Dobs A, Grunfeld C, Illicit Drug Use and HIV Treatment Outcomes in a US Cohort, AIDS,2008,22,3,357-365, England, PMID 18195562
  
  Journal Citations
  
  Basaria, S.; Muller, D.C.; Carducci, M.A.; Egan, J.; Dobs, A.S. Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy. Cancer. 2006 Feb 1;106(3):581-588.
  
  Braga-Basaria, M.; Dobs, A.S.; Muller, D.C.; Carducci, M.A.; John, M.; Egan, J.; Basaria, S. Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapy. J Clin Oncol. 2006 Aug 20;24(24):3979-3983.
  
  Braga-Basaria, M.; Muller, D.C.; Carducci, M.A.; Dobs, A.S.; Basaria, S. Lipoprotein profile in men with prostate cancer undergoing androgen deprivation therapy. International journal of impotence research. 2006 Sep-Oct;18(5):494-498.
  
  Levinson, N.M.; Kuchment, O.; Shen, K.; Young, M.A.; Koldobskiy, M.; Karplus, M.; Cole, P.A.; Kuriyan, J. A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol. 2006 May;4(5):e144.
  
  Maggio, M.; Blackford, A.; Taub, D.; Carducci, M.; Ble, A.; Metter, E.J.; Braga-Basaria, M.; Dobs, A.; Basaria, S. Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapy. J Androl. 2006 Nov-Dec;27(6):725-728.
  
  Basaria, S.; Muller, D.C.; Carducci, M.A.; Egan, J.; Dobs, A.S. Relation between duration of androgen deprivation therapy and degree of insulin resistance in men with prostate cancer. Archives of internal medicine. 2007 Mar 26;167(6):612-613.
  
  Rohrmann, S.; Nelson, W.G.; Rifai, N.; Brown, T.R.; Dobs, A.; Kanarek, N.; Yager, J.D.; Platz, E.A. Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans. J Clin Endocrinol Metab. 2007 Jul;92(7):2519-2525.
  
  Selvin, E.; Feinleib, M.; Zhang, L.; Rohrmann, S.; Rifai, N.; Nelson, W.G.; Dobs, A.; Basaria, S.; Golden, S.H.; Platz, E.A. Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care. 2007 Feb;30(2):234-238.
  
  Paller, C.J.; Shiels, M.S.; Rohrmann, S.; Basaria, S.; Rifai, N.; Nelson, W.; Platz, E.A.; Dobs, A. Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of men. Clinical endocrinology. 2009 Jan;70(1):26-34.
  
  Sharma, P.; Wisniewski, A.; Braga-Basaria, M.; Xu, X.; Yep, M.; Denmeade, S.; Dobs, A.S.; DeWeese, T.; Carducci, M.; Basaria, S. Lack of an effect of high dose isoflavones in men with prostate cancer undergoing androgen deprivation therapy. J Urol. 2009 Nov;182(5):2265-2272.
  
  Shiels, M.S.; Rohrmann, S.; Menke, A.; Selvin, E.; Crespo, C.J.; Rifai, N.; Dobs, A.; Feinleib, M.; Guallar, E.; Platz, E.A. Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men. Cancer Causes Control. 2009 Aug;20(6):877-886.
  
  Menke, A.; Guallar, E.; Rohrmann, S.; Nelson, W.G.; Rifai, N.; Kanarek, N.; Feinleib, M.; Michos, E.D.; Dobs, A.; Platz, E.A. Sex steroid hormone concentrations and risk of death in US men. Am J Epidemiol. 2010 Mar 1;171(5):583-592.
  
  Mondul, A.M.; Selvin, E.; Rohrmann, S.; Menke, A.; Feinleib, M.; Kanarek, N.; Rifai, N.; Dobs, A.S.; Platz, E.A. Association of serum cholesterol and cholesterol-lowering drug use with serum sex steroid hormones in men in NHANES III. Cancer Causes Control. 2010 Oct;21(10):1575-1583.

Memberships

• American Andrology Society
• Institute of Medicine Roundtable in Clinical Research
• The Endocrine Society

Professional Activities

• Albert Einstein College of Medicine, Medical Residency, 1/1/78 - 1/1/81
• JHU-SYSU (China) Clinical Research Collaboration, Director, 1/1/11 - 1/1/20
• Johns Hopkins Clinical Research Network, Director, 1/1/10
• Johns Hopkins University School of Medicine, Vice-Chair, 1/1/96 - 1/1/01
• Johns Hopkins University School of Medicine, Vice-Chair, 1/1/01 - 1/1/18
• NCI-funded Center to Reduce Cancer Disparities, Director, 1/1/12 - 1/1/18