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Melanie Dispenza

Melanie Dispenza, MD, PhD

Allergy and Immunology

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Highlights

Age Groups Seen

  • Young Adult 18-25
  • Adult 26-64
  • Older Adult 65+

Languages

  • English

Gender

Female

Johns Hopkins Affiliations:

  • Johns Hopkins School of Medicine Faculty

About Melanie Dispenza

Primary Academic Title

Assistant Professor of Medicine

Johns Hopkins Physician

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Background

Dr. Dispenza evaluates and treats adults at the Johns Hopkins Asthma & Allergy Center located on the Bayview campus. Her clinical interests include mastocytosis and anaphylaxis. She is an active member of the American Initiative in Mast Cell Diseases.  Additionally, as co-director for the Johns Hopkins Center for Anaphylaxis and Drug Hypersensitivity, her research focuses on IgE-mediated mechanisms of allergies and novel strategies for the diagnosis, prevention, and treatment of anaphylaxis.

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Selected Publications

B Arce, NM Vilela, KA Sokol, S Alvarez-Arango, L Iacobelli, ET Oliver, D Croote, BS Bochner, DW MacGlashan, Jr., MC Dispenza.  The Bruton’s tyrosine kinase inhibitor acalabrutinib aborts ongoing acute food-induced anaphylactic reactions in humanized mice.  Epub 2025 Jul 17.  PMID: 40683570. 

RV Suresh, C Dunnam, D Vaidya, RA Wood, BS Bochner, DW MacGlashan, Jr., MC Dispenza.  A phase 2 study of Bruton’s tyrosine kinase inhibition for the prevention of anaphylaxis.  Journal of Clinical Investigation. 2023. August;133(16):e172335.  PMID 37384412.

MC Dispenza, RA Krier-Burris, KD Chhiba, BJ Undem, PA Robida, BS Bochner.  Bruton’s tyrosine kinase inhibition effectively protects against IgE-mediated anaphylaxis.  Journal of Clinical Investigation.  2020.  Sept;130(9): 4759-4770.  PMID: 32484802.  

MC Dispenza, JA Pongracic, AM Singh, BS Bochner.  Short Term Ibrutinib Therapy Suppresses Skin Test Responses and Eliminates IgE-Mediated Basophil Activation in Adults with Peanut or Tree Nut Allergy.  Journal of Allergy and Clinical Immunology.  2018.  May;141(5): 1914-1916.  PMID: 29360526. 

Locations

  1. Johns Hopkins Bayview Medical Center
    • 5501 Hopkins Bayview Circle, Allergy & Asthma Center, 2nd Floor, Baltimore, MD 21224
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Expertise

Education

  • Fellowship: McGaw Medical Center Northwestern University, Allergy and Clinical Immunology, 2018
  • Residency: McGaw Medical Center Northwestern University, Internal Medicine, 2015
  • Medical Education: Penn State College of Medicine, MD, 2013
  • Graduate School: Penn State University, PhD, 2011

Board Certifications

  • Allergy & Immunology: American Board of Allergy and Immunology, 2018
  • Internal Medicine: American Board of Internal Medicine, 2016

Insurance

Search plans
  • Aetna
  • CareFirst
  • Cigna
  • First Health
  • Geisinger Health Plan
  • HealthSmart/Accel
  • Johns Hopkins Health Plans
  • MultiPlan
  • Pennsylvania's Preferred Health Networks (PPHN)
  • Point Comfort Underwriters
  • Private Healthcare Systems (PHCS)
  • Veteran Affairs Community Care Network (Optum-VACCN)