Highlights
Age Groups Seen
- Young Adult 18-25
- Adult 26-64
- Older Adult 65+
Languages
- English
In-Network Plans
View All Accepted Plans (12)Gender
FemaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Christine Hann
Primary Academic Title
Associate Professor of Oncology
Johns Hopkins Physician
Background
Christine L Hann, completed her MD and Ph.D. at Jefferson Medical College/Thomas Jefferson University follwed by an internal medicine residency at the University of Chicago Hospitals. Following a fellowship at Johns Hopkins University in Hematology and Oncology, Dr. Hann joined the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center as a member of the Upper Aerodigestive Cancer Program and sees patients with non-small cell and small cell lung cancer.
Dr. Hann's research focus is on developing novel therapeutics for lung cancer, particularly small cell lung cancer (SCLC) and neuroendocrine tumors (NETs) such as carcinoid tumors of the lung. As a faculty member she is involved in both clinical and laboratory research.
Specific research projects include:
1) Studying mechanisms of resistant to small molecule inhibitors of the antiapoptotic protein, BCL-2 using patient-derived xenograft models. Her preclinical work has led to an NCI-sponsored Phase 1/2 clinical trial combining a BCL-2 inhibitor with a TORC1/2 inhibitors which is currently underway (NCT03366103).
2) Preclinical evaluation of various therapeutics including epigenetic modulators (LSD1 inhibitors) and nanoliposome chemotherapy in SCLC PDXs;
3) Modeling and characterizing chemoradiotherapy resistance in preclinical models of SCLC. She, along with Dr. Luigi Marchionni in Biostatistics and Dr. Phuoc Tran in the Department of Radiation Oncology, were recently awarded a 5-year NCI-sponsored U01 grant to study mechanisms of chemoradiation resistance in SCLC.
Dr. Hann is PI of several trials in SCLC and NSCLC and is leading investigator-initiated clinical trials in SCLC and NETs.
Centers and Institutes
Clinical Trial Keywords
lung cancer
Find a Clinical Trial
View all trials by this principal investigator.
Videos
Research Interests
New drug development for lung cancer, Small cell and non-small cell lung cancer
PubMed - Publications
Selected Publications
Belani CP, Dahlberg SE, Rudin CM, Fleisher M, Chen HX, Takebe N, Velasco MR Jr, Tester WJ, Sturtz K, Hann CL, Shanks JC, Monga M, Ramalingam SS, Schiller JH. Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive-stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E1508). Cancer. 2016 May 10. doi: 10.1002/cncr.30062. [Epub ahead of print] PMID: 27163943
Bunn PA Jr, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR. Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes? J Thorac Oncol. 2016 Apr;11(4):453-74. doi: 10.1016/j.jtho.2016.01.012. Epub 2016 Jan 30. Review. No abstract available. PMID: 26829312
MacDiarmid JA, Langova V, Bailey D, Pattison ST, Pattison SL, Christensen N, Armstrong LR, Brahmbhatt VN, Smolarczyk K, Harrison MT, Costa M, Mugridge NB, Sedliarou I, Grimes NA, Kiss DL, Stillman B, Hann CL, Gallia GL, Graham RM, Brahmbhatt H. Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model. PLoS One. 2016 Apr 6;11(4):e0151832. doi: 10.1371/journal.pone.0151832. eCollection 2016. PMID: 27050167
Rudin CM, Ismaila N, Hann CL, Malhotra N, Movsas B, Norris K, Pietanza MC, Ramalingam SS, Turrisi AT 3rd, Giaccone G. Treatment of Small-Cell Lung Cancer: American Society of Clinical Oncology Endorsement of the American College of Chest Physicians Guideline. J Clin Oncol. 2015 Dec 1;33(34):4106-11. doi: 10.1200/JCO.2015.63.7918. Epub 2015 Sep 8. PMID: 26351333
Sun H, Luo L, Lal B, Ma X, Chen L, Hann CL, Fulton AM, Leahy DJ, Laterra J, Li M. A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nat Commun. 2016 Feb 4;7:10339. doi: 10.1038/ncomms10339. PMID: 26842342
Honors
- Young Clinical Scientist Award, Flight Attendant Medical Research Institute, 1/1/07
- Pearl M. Stetler Fellowship Award for Women Physicians, Johns Hopkins University, 1/1/06
- Young Investigator Award, American Society of Clinical Oncology, 1/1/05
Memberships
- American Association for Cancer Research
- American Society of Clinical Oncology
- International Association for the Study of Lung Cancer
Locations
- Johns Hopkins Bayview Medical Center
- 300 Mason Lord Drive, Kimmel Cancer Center, Baltimore, MD 21224
- Get Directions
- phone: 410-550-1711
- fax: 410-550-1116
- Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville
- 10803 Falls Road, Pavilion III STE 1500, Lutherville, MD 21093
- Get Directions
- phone: 410-583-2970
- fax: 410-583-2980
- Skip Viragh Outpatient Cancer Center
- 201 North Broadway Street, Viragh BLDG 5th FL, Baltimore, MD 21287
- Get Directions
- phone: 410-955-8964
- fax: 410-367-2194
Expertise
Education
- Fellowship: Johns Hopkins University School of Medicine, Hematology and Oncology, 2007
- Residency: University of Chicago Medicine, Internal Medicine, 2002
- Medical Education: Sidney Kimmel Medical College, Biochemistry and Molecular Biology, MD PhD, 2000
Board Certifications
- Medical Oncology: American Board of Internal Medicine, 2006
Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
4.9 out of 5
118 ratings, 54 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 5 out of 5 starsReviewed on 6/15/2026
Best hospital in the business
- 5 out of 5 starsReviewed on 6/12/2026
She was great and informed me of my conditions
- 5 out of 5 starsReviewed on 6/12/2026
Physician was a good listener and caring.
- 5 out of 5 starsReviewed on 6/8/2026
Very concerned for my health
- 5 out of 5 starsReviewed on 6/5/2026
Dr. Hann is the best!
- 5 out of 5 starsReviewed on 6/5/2026
Knowledgeable, great communicator, compassionate, honest and clear
- 5 out of 5 starsReviewed on 6/5/2026
Dr. Hann is not only extremely helpful in providing information; she is a very willing listener and values patient information. She has on a number of occasions checked accuracy of information. When Dr. Hann and I agree on a method to proceed I feel good about it, having confidence that this is the way to go for best chance of success
- 5 out of 5 starsReviewed on 6/4/2026
Dr Hann took as much time as I wanted. She answered several question s and followed up later in day with a couple question I had by calling me on my cell.
- 5 out of 5 starsReviewed on 6/1/2026
My family was present at that video visit and the provider was very good about answering their questions as well as mine
- 5 out of 5 starsReviewed on 6/1/2026
Excellent physician. Dr Hann listens and responds to all concerns.
- 5 out of 5 starsReviewed on 6/1/2026
Thoughtful, well informed andd experienced. A great resource.
- 5 out of 5 starsReviewed on 5/18/2026
DR Haan is the best! She really cares about her patients, and quite frankly, is the reason I am still here!
- 5 out of 5 starsReviewed on 5/15/2026
She is extremely knowledgeable, a great listener, and very friendly and helpful.
- 5 out of 5 starsReviewed on 5/14/2026
Compassionate, caring, and listening carefully to the needs of patients. Thank you so much, Dr. Hann!
- 4 out of 5 starsReviewed on 5/14/2026
Provider was very helpful . Corrected slight misunderstanding of my visit .
- 5 out of 5 starsReviewed on 4/30/2026
Very knowledgeable and concerned about my welfare.
- 5 out of 5 starsReviewed on 4/20/2026
Informed, provide information, opened the questions
- 5 out of 5 starsReviewed on 4/20/2026
Patient, Kind, knowledgeable, and incredible bed side manner
- 5 out of 5 starsReviewed on 4/10/2026
Dr. Hann is very courteous and knowledgeblle in her field.
- 5 out of 5 starsReviewed on 4/6/2026
Excellent
- 5 out of 5 starsReviewed on 4/3/2026
Dr Hann is amazing and when with her she makes me feel very seen and heard. Her bedside manner Is exceptional. [staff] with scheduling was amazing and as warm and friendly as possible.
- 5 out of 5 starsReviewed on 4/2/2026
Dr. Hann was extremely ready about my past medical history at the time of the visit. She took her time to listen to me and explained details of my treatment. She was Courteous, Kind and Caring.
- 5 out of 5 starsReviewed on 3/30/2026
Very helpful...listened to my questions and answered appropriately
- 5 out of 5 starsReviewed on 3/26/2026
She is very helpful
- 5 out of 5 starsReviewed on 3/6/2026
Dr Hann is very knowledgeable, responsive, experienced, empathetic. She's great to work with and provides excellent care.
- 5 out of 5 starsReviewed on 3/6/2026
Dr. Hann is wonderful! Great care as well as great bedside manner care!
- 5 out of 5 starsReviewed on 2/27/2026
Dr Hann was very courteous and very professional. I was very pleased and impressed.
- 5 out of 5 starsReviewed on 2/6/2026
Excellent!
- 5 out of 5 starsReviewed on 2/5/2026
Dr Hann was wonderful. Very compassionate and caring in both listening and explaining diagnosis thoughts and alternatives. Her care was comforting and took time to answer all questions and explain a very complex issues in plain English. She is obviously an expert and we are blessed to have been referred to her.
- 5 out of 5 starsReviewed on 2/2/2026
Enjoy meeting with her
- 5 out of 5 starsReviewed on 1/16/2026
Dr Hann is wonderful- she is attentive, caring and a great listener
- 5 out of 5 starsReviewed on 1/12/2026
Annually I am scheduled for a CT scan Thereafter I speak with Christine Hann to discuss results of scan. Because of the distance between my home and the Dr.'s office, we speak by phone regarding the results
- 5 out of 5 starsReviewed on 1/9/2026
Very thorough and compassionate!
- 5 out of 5 starsReviewed on 1/8/2026
Knowledgeable, caring, trying to the best for my treatment, listening
- 5 out of 5 starsReviewed on 12/31/2025
Dr. Hann was very caring. It was my initial consultation & I was pleased with her knowledge about this awful disease.
- 5 out of 5 starsReviewed on 12/31/2025
Dr. Hann is always very empathetic as well as professional.
- 5 out of 5 starsReviewed on 12/29/2025
Dr Hann is an excellent physician. She take time to make sure I understand what has been said and answers any and all questions I have.
- 5 out of 5 starsReviewed on 12/29/2025
Nice, professional
- 5 out of 5 starsReviewed on 12/22/2025
Very knowledgeable and answered all my questions
- 5 out of 5 starsReviewed on 12/22/2025
Dr Hann is is very caring and knowledgeable provider and a terrific listener. She very much cares for and respects her patients and sympathized with them during a very difficult time.
- 5 out of 5 starsReviewed on 12/22/2025
She's wonderful!
- 5 out of 5 starsReviewed on 12/5/2025
Excellent. Caring and knowledgeable. Clearly communicates. Takes time needed.
- 5 out of 5 starsReviewed on 12/5/2025
Caring, knowledgeable, positive, smart, kind
- 5 out of 5 starsReviewed on 11/24/2025
I find Dr. Hann helpful and kind. I trust her.
- 5 out of 5 starsReviewed on 11/17/2025
Excellent Physician. Listens and provides detailed information.
- 5 out of 5 starsReviewed on 11/10/2025
Dr Hann and [staff] were very attentive and kind
- 5 out of 5 starsReviewed on 10/31/2025
My new provider made me feel comfortable with my visit with her. She answered my questions I needed to know .
- 5 out of 5 starsReviewed on 10/20/2025
Very good
- 5 out of 5 starsReviewed on 10/2/2025
Dr. Hann is the best there is. She has taken such good care of me. She is not only extremely professional, she is also completely down to Earth. Actually there is no doubt in my mind that she saved my life.
- 5 out of 5 starsReviewed on 9/22/2025
Very good
- 5 out of 5 starsReviewed on 9/18/2025
Christine was very personable, easy to talk to and she is very smart about the cancer I have and easy to work with.
- 5 out of 5 starsReviewed on 8/18/2025
Knowledgeable, empathetic, kind, prepared with approaches that are best for the patient. A good listener with ready suggestions. The very best. Glad Dr. Hann is my physician.
- 5 out of 5 starsReviewed on 7/28/2025
Dr. Hann has and always will be my first person to consult in my decisions. She's the best . She cares about her patients.
- 5 out of 5 starsReviewed on 7/25/2025
I love my oncologist.